Abstract: The invention relates to specified benzamide compounds of formula (1), and pharmaceutical compositions containing the compounds. The compounds may be inducers of ?1-antitrypsin (A1AT), and may be used in the treatment of a disease or disorder such as ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: The invention relates to specified benzamide compounds of formula (1), and pharmaceutical compositions containing the compounds. The compounds may be inducers of ?1-antitrypsin (A1AT), and may be used in the treatment of a disease or disorder such as ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: A fiber optic installation device is disclosed for easily and efficiently installing fiber into an existing conduit in order to provide telecommunication and other services. The installation device includes a housing having first and second entry points. A first tube is releasably coupled to the first entry point, and configured for receiving a fiber cable, and a second tube is releasably coupled to the second entry point, and configured for receiving and securing an existing conduit so that the fiber optic cable can be pushed through and installed into the conduit. The cable is driven through the device via a drive wheel that is coupled to a drive shaft being driven by a standard electric drill. To prevent slippage of the cable, a pincher wheel is adjusted up or down via a knob to ensure the fiber optic cable remains in contact with the drive wheel throughout the installation process.

Abstract: A computer-implemented method for remote operation of one or more weighbridges. The method comprises: receiving, at a user terminal comprising a display: weight signaling from a weighbridge, the weight signaling indicative of a weight of a load present on the weighbridge; and image signaling from an image capture device located at the weighbridge, the image signaling indicative of a real-time image of the weighbridge captured by the image capture device; displaying, on the display, a weighbridge use indicator indicative of the weight present on the weighbridge in dependence on the weight signaling and a real-time image of the weighbridge in dependence on the image signaling; receiving, from the user terminal, control signaling indicative of an operator user input to control an operation element of the weighbridge; and in response to receiving the control signaling, controlling the operation element according to the control signaling.

Abstract: Provided herein are compositions, methods and uses that relate to or result from providing separation media having at least one flocculant ligand covalently attached to a base surface or support, and the separation and/or purification of biological molecules using the separation media of the present disclosure. Certain embodiments provide separation media which under certain modes of operation, enhance the separation of the molecule of interest from impurities.

Abstract: Provided herein are compositions, methods and uses that relate to or result from providing separation media having at least one flocculant ligand covalently attached to a base surface or support, and the separation and/or purification of biological molecules using the separation media of the present disclosure. Certain embodiments provide separation media which under certain modes of operation, enhance the separation of the molecule of interest from impurities.

Abstract: A media marker mechanism may be used a cloud service to determine up-to-date context regarding playback of a media content stream on a user device. The cloud service may insert a media content item into a media content stream and/or combine media content items into a media content stream. The cloud service may implement the media marker mechanism to tag a content item with metadata that can be read by the user device. The user device can play the streaming media content and, when the tagged content item plays, read the metadata and send it to the cloud service. The cloud service can use the metadata to enrich the media content delivery by, for example, sending the user device a companion image to display, providing a link to make the companion image clickable, handling requests referring to the media content, etc.

Abstract: A media marker mechanism may be used to send, to a cloud service, up-to-date context regarding playback of a media content stream on a user device. The cloud service may insert a media content item into a media content stream and/or combine media content items into a media content stream. The cloud service may implement the media marker mechanism to tag a content item with metadata that can be read by the user device. The user device can play the streaming media content and, when the tagged content item plays, read the metadata and send it to the cloud service. The cloud service can use the metadata to enrich the media content delivery by, for example, providing a companion image that the user device can display while paying the tagged content item, providing a link to make the companion image clickable, handling requests referring to the media content, etc.

Abstract: Techniques are described for maintaining contextual data to support content-related actions. In an example, a system stories second content at a source. The source is associated with first content. The system sends, to a device, an object that indicates the first content. From the device at a first time, the system receives first data indicating a first request for the second content and including source information that indicates the source. From the device at a second time, the system receives second data indicating a second request for the second content, the second data including the source information, the first data and the second data received at a frequency indicated by the object. The system determines that the requests are associated with the first content based on the source information included in the received data, and stores third data indicating a presentation of the first content by the device.

Abstract: A ferrule system includes: a first ferrule comprising a proximal end for engaging a first implement and a threaded portion opposite the proximal end; and a second ferrule comprising a distal portion for engaging a second implement, a proximal portion opposite the distal portion and comprising teeth, a threaded portion intermediate the distal portion and proximal portion and configured to engage the threaded portion of the first ferrule. Teeth are mounted on the first ferrule and are biased to automatically engage the teeth of the proximal portion of the second ferrule as the threaded portion of the first ferrule engages the threaded portion of the second ferrule such that only tightening rotation of the second ferrule relative to the first ferrule is permitted when the teeth mounted on the first ferrule are automatically engaged with the teeth of the proximal portion of the second ferrule.

Abstract: Provided herein are compositions, methods and uses that relate to or result from providing separation media having at least one flocculant ligand covalently attached to a base surface or support, and the separation and/or purification of biological molecules using the separation media of the present disclosure. Certain embodiments provide separation media which under certain modes of operation, enhance the separation of the molecule of interest from impurities.

Abstract: A concentrated photovoltaic (CPV) system for solar power generation incorporating an array of receiving elements in a panel with optical receiving components designed to accept light from an angle offset from the normal optical axis of the placement of the panel. The offset angle is approximately equal to the difference in the mean position of the sun, and the installed angle of the panel thereby enabling the elements to effectively point directly at the sun even if the angle of the sun is outside the limited angular rotation of the solar tracking system.

Abstract: Methods and kits for preparing biologically derived fluids for subsequent biomarker analysis by mass spectrometry are provided.

Abstract: An optical amplifier is disclosed comprising a signal semiconductor optical amplifier having a waveguide, forming at least part of a signal path between an input and an output, extending along a signal active region for amplification of a signal. The amplifier also includes a control active region of semiconductor material having a gain which is controllable independently from the gain of the signal active region. The amplifier also includes a laser cavity containing both the signal active region and the control active region and being capable of clamping the gain of the signal active region, and the control active region is arranged not to amplify a signal in the signal path within a predetermined signal band.

Abstract: A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced in accordance with the present teachings is useful for suppression of matrix ions in the low mass region (<1,000 daltons) of a MALDI-MS spectrum.

Abstract: A method of producing an optical grating component including only a single continuous grating field formed in a longitudinal waveguide rib, the method including the steps of defining a grating in an optic chip including a portion thereof through which the longitudinal waveguide rib is to extend, and then defining the lateral edges of the longitudinal rib in the optic chip, whereby any portion of the grating extending laterally beyond the lateral width of the rib is removed in the step of defining the lateral edges of the rib leaving a single continuous grating field that has straight lateral grating boundaries that are laterally aligned with the straight lateral edges of the rib.

Abstract: A method of cleaning gas turbine compressors using crushed, solid, sublimable material, such as dry ice, which can be used in during low temperature conditions, poses no risk of ice formation, clogging cooling hole passages, or degrading the emissions from the turbine.

Abstract: An external cavity laser system comprises a reflective optical amplifier 3, an input waveguide 4 for receiving an optical input signal from the reflective optical amplifier 3, a Bragg grating 5 for reflecting a portion of the optical input signal back along the input waveguide 4 to define a resonant cavity with the optical amplifier, and a reflection photodiode 30 for detecting the signal portion reflected by the grating 5 and for supplying an electrical feedback signal indicative of the signal portion. A transmission photodiode 6 is also provided for detecting the signal portion transmitted by the grating 5 and for supplying an electrical feedback signal indicative of that signal portion. These feedback signals are supplied to a control circuit which controls a phase modulator to modulate the phase of the optical input signal so as to ensure zero detuning between the dominant signal mode and the peak of the grating.

Abstract: A hybridized fiber amplifier/waveguide system for amplifying a multichannel signal comprises a planar waveguide structure (1) incorporating a pump laser (2) providing an output signal of a defined wavelength, a doped optical fiber (8) attached to the structure and having an absorption wavelength corresponding to the wavelength of the laser output signal, and coupling means (5) for supplying the output signal of the laser and the multichannel signal to the doped fiber to amplify the multichannel signal.

Abstract: A method of cleaning gas turbine compressors using crushed, solid, sublimatable material, such as dry ice, which can be used in during low temperature conditions, poses no risk of ice formation, clogging cooling hole passages, or degrading the emissions from the turbine.