Patents by Inventor Andrew V. Schally
Andrew V. Schally has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230126533Abstract: The present disclosure is directed to a method of treating an inflammatory disorder, such as sarcoidosis, using a growth hormone-releasing hormone (GHRH) antagonist.Type: ApplicationFiled: October 27, 2022Publication date: April 27, 2023Inventors: Mehdi Mirsaeidi, Chongxu Zhang, Andrew V. Schally, Renzhi Cai, Runxia Tian
-
Publication number: 20220143149Abstract: The disclosure provides a method of treating sarcoidosis, the method comprising administering a GHRH antagonist to mammalian subject in need thereof.Type: ApplicationFiled: January 17, 2022Publication date: May 12, 2022Inventors: Mehdi Mirsaeidi, Chongxu Zhang, Andrew V. Schally, Renzhi Cai
-
Publication number: 20220000983Abstract: Described herein are compositions and methods for treating pulmonary fibrosis and cancer. The compositions include growth hormone releasing hormone peptides. The methods include reducing lung inflammation, lung scarring, reducing expression of T cell receptor complex genes as well as inhibiting tumor growth.Type: ApplicationFiled: August 6, 2021Publication date: January 6, 2022Inventors: Robert M. Jackson, Andrew V. Schally, Renzhi Cai
-
Publication number: 20210395327Abstract: Described herein are compositions and methods for treating pulmonary fibrosis and cancer. The compositions include growth hormone releasing hormone peptides. The methods include reducing lung inflammation, lung scarring, reducing expression of T cell receptor complex genes as well as inhibiting tumor growth.Type: ApplicationFiled: August 6, 2021Publication date: December 23, 2021Inventors: Robert M. Jackson, Andrew V. Schally, Renzhi Cai, Xianyang Zhang Cai, Haibo Wang, Wei Sha
-
Patent number: 9855312Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In additional embodiment, a method of promoting vasculogenesis in a mammal may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In a further embodiment, a method of promoting differentiation of mesenchymal stem cells into endothelial cells may involve contacting mesenchymal stem cells with at least one GHRH agonist peptide.Type: GrantFiled: December 23, 2013Date of Patent: January 2, 2018Assignees: UNIVERSITY OF MIAMI, THE UNITED STATES OF AMERICA, REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Andrew V. Schally, Joshua M. Hare, Norman L. Block, Samirah A. Gomes, Rosemeire M. Kanashiro-Takeuchi
-
Patent number: 9393271Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient. In some embodiments, the islet cells and/or tissues comprising islet cells may be optionally exposed to GHRH and/or at least one agonist of GHRH prior to transplantation into a patient.Type: GrantFiled: December 23, 2013Date of Patent: July 19, 2016Assignees: University of Miami, The United States of America, Represented by the Department of Veterans Affairs, Dresden University of TechnologyInventors: Andrew V. Schally, Norman L. Block, Stefan Bornstein, Barbara Ludwig
-
Publication number: 20160166652Abstract: There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc, Me-NH-Sub, PhAc-Ada, Ac-Ada-D-Phe, Ac-Ada-Phe, Dca-Ada, Dca-Amc, Nac-Ada, Ada-Ada, or CH3—(CH2)10—CO-Ada, at the N-Terminus and ?-Ala, Amc, Apa, Ada, AE2A, AE4P, ?-Lys(?-NH2), Agm, Lys(Oct) or Ahx, at the C-terminus. These analogs inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers, and inhibit the hyperplastic and benign proliferative disorders of various organs, through a direct effect on the cancerous and non-malignant cells. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, result from replacement of various amino acids.Type: ApplicationFiled: December 16, 2015Publication date: June 16, 2016Inventors: Andrew V. SCHALLY, Marta ZARANDI, Jozsef L. VARGA, Ren Zhi CAI
-
Patent number: 9260504Abstract: There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc, Me-NH-Sub, PhAc-Ada, Ac-Ada-D-Phe, Ac-Ada-Phe, Dca-Ada, Dca-Amc, Nac-Ada, Ada-Ada, or CH3—(CH2)10—CO-Ada, at the N-Terminus and ?-Ala, Amc, Apa, Ada, AE2A, AE4P, ?-Lys(?-NH2), Agm, Lys(Oct) or Ahx, at the C-terminus. These analogs inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers, and inhibit the hyperplastic and benign proliferative disorders of various organs, through a direct effect on the cancerous and non-malignant cells. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, result from replacement of various amino acids.Type: GrantFiled: February 19, 2014Date of Patent: February 16, 2016Assignees: University of Miami, The United States of America, Represented by the Department of Veterans AffairsInventors: Andrew V. Schally, Marta Zarandi, Jozsef L. Varga, Ren Zhi Cai
-
Publication number: 20150274798Abstract: There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their physiological activity in solution for extended periods of time and resist enzymic degradation in the body. These novel and useful properties appear to be due to novel substitution patterns ant at the 1, 15, 27 and 29 positions on the peptide.Type: ApplicationFiled: June 11, 2015Publication date: October 1, 2015Inventors: Andrew V. SCHALLY, Ren Zhi CAI, Marta ZARANDI
-
Patent number: 9079974Abstract: There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their physiological activity in solution for extended periods of time and resist enzymic degradation in the body. These novel and useful properties appear to be due to novel substitution patterns ant at the 1, 15, 27 and 29 positions on the peptide.Type: GrantFiled: December 21, 2011Date of Patent: July 14, 2015Assignees: The University of Miami, The United States of America, represented by the Department of Veterans AffairsInventors: Andrew V Schally, Ren Zhi Cai, Marta Zarandi
-
Publication number: 20150174207Abstract: Embodiments of the present disclosure are directed to methods to treat a subject having cancer. In one embodiment, a method of treating a subject with cancer may comprise administering a therapeutically effective amount of at least one GHRH agonist peptide in combination with at least one anticancer agent. In another embodiment, a method of killing cancer cells may comprise contacting the cancer cells with a composition comprising at least one GHRH agonist peptide and at least one anticancer agent. In some embodiments, the method may be in vitro or in vivo. In an additional embodiment, a method of killing cancer stem cells may comprise contacting the cancer stem cells with a composition comprising at least one GHRH agonist peptide and at least one anticancer agent.Type: ApplicationFiled: December 24, 2014Publication date: June 25, 2015Inventors: Andrew V. SCHALLY, Miklos JASBERENYI
-
Publication number: 20150166617Abstract: Disclosed herein are compositions of GHRH peptide antagonists, and methods to treat Alzheimer's disease and other neurodegenerative disorders. Such compounds are useful for therapeutics, for protecting neuronal cells from cell-death and for promoting neuronal cell viability.Type: ApplicationFiled: June 27, 2013Publication date: June 18, 2015Inventors: Andrew V. Schally, Miklos Jasberenyi, Norman L. Block
-
Patent number: 8980249Abstract: Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.Type: GrantFiled: June 3, 2011Date of Patent: March 17, 2015Assignees: University of Miami, Dresden University of TechnologyInventors: Andrew V. Schally, Barbara Ludwig, Stefan Bornstein, Norman L. Block
-
Publication number: 20140206836Abstract: There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc, Me-NH-Sub, PhAc-Ada, Ac-Ada-D-Phe, Ac-Ada-Phe, Dca-Ada, Dca-Amc, Nac-Ada, Ada-Ada, or CH3—(CH2)10—CO-Ada, at the N-Terminus and ?-Ala, Amc, Apa, Ada, AE2A, AE4P, ?-Lys(?-NH2), Agm, Lys(Oct) or Ahx, at the C-terminus. These analogs inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers, and inhibit the hyperplastic and benign proliferative disorders of various organs, through a direct effect on the cancerous and non-malignant cells. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, result from replacement of various amino acids.Type: ApplicationFiled: February 19, 2014Publication date: July 24, 2014Applicants: U.S.A., represented by the Department of Veterans Affairs, University of MiamiInventors: Andrew V. SCHALLY, Marta ZARANDI, Jozsef L. VARGA, Ren Zhi CAI
-
Publication number: 20140193378Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient. In some embodiments, the islet cells and/or tissues comprising islet cells may be optionally exposed to GHRH and/or at least one agonist of GHRH prior to transplantation into a patient.Type: ApplicationFiled: December 23, 2013Publication date: July 10, 2014Applicants: UNIVERSITY OF MIAMI, DRESDEN UNIVERSITY OF TECHNOLOGY, U.S.A., REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Andrew V. SCHALLY, Norman L. BLOCK, Stefan BORNSTEIN, Barbara LUDWIG
-
Publication number: 20140179604Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In additional embodiment, a method of promoting vasculogenesis in a mammal may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In a further embodiment, a method of promoting differentiation of mesenchymal stem cells into endothelial cells may involve contacting mesenchymal stem cells with at least one GHRH agonist peptide.Type: ApplicationFiled: December 23, 2013Publication date: June 26, 2014Applicants: U.S.A., REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF MIAMIInventors: Andrew V. SCHALLY, Joshua M. HARE, Norman L. BLOCK, Samirah A. GOMES, Rosemeire M. KANASHIRO-TAKEUCHI
-
Patent number: 8691942Abstract: There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc, Me-NH-Sub, PhAc-Ada, Ac-Ada-D-Phe, Ac-Ada-Phe, Dca-Ada, Dca-Amc, Nac-Ada, Ada-Ada, or CH3—(CH2)10—CO-Ada, at the N-Terminus and ?-Ala, Amc, Apa, Ada, AE2A, AE4P, ?-Lys(?-NH2), Agm, Lys(Oct) or Ahx, at the C-terminus. These analogs inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers, and inhibit the hyperplastic and benign proliferative disorders of various organs, through a direct effect on the cancerous and non-malignant cells. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, result from replacement of various amino acids.Type: GrantFiled: September 25, 2010Date of Patent: April 8, 2014Assignees: University of Miami, U.S.A. Represented by the Dept. of Veterans AffairsInventors: Andrew V. Schally, Marta Zarandi, Jozsef L. Varga, Ren Zhi Cai
-
Publication number: 20140057847Abstract: Disclosed herein are methods demonstrating that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent fashion. Following experimental myocardial infarction (MI), rats were randomly assigned to receive, during a 4 week period, either placebo (n=14), rat recombinant GH (rrGH, n=8) or JI-38 (n=8; 50 ?g/Kg/day), a potent GHRH-agonist. JI-38 did not elevate serum levels of GH or IGF-I, but markedly attenuated the degree of cardiac functional decline and remodeling after injury. In contrast, GH administration markedly elevated body weight, heart weight, circulating GH and IGF-I, but did not offset the decline in cardiac structure and function. Whereas, both JI-38 and GH augmented levels of cardiac precursor cell proliferation, only JI-38 increased anti-apoptotic gene expression. Collectively, these findings demonstrate that within the heart, GHRH-agonists can activate cardiac repair following MI.Type: ApplicationFiled: July 22, 2013Publication date: February 27, 2014Applicants: United States of America, Represented by The Department of Veterans Affairs, University of MiamiInventors: Andrew V. SCHALLY, Norman L. Block, Joshua M. Hare, Rosemeire Miyuki Kanashiro-Takeuchi
-
Publication number: 20140058068Abstract: There are provided a novel series of peptide analogs of hGH-RH(1-29)NH2 and hGH-RH(1-30)NH2 which show high activities in stimulating the release of pituitary GH in animals. They retain their physiological activity in solution for extended periods of time and resist enzymic degradation in the body. These novel and useful properties appear to be due to novel substitution patterns ant at the 1, 15, 27 and 29 positions on the peptide.Type: ApplicationFiled: December 21, 2011Publication date: February 27, 2014Inventors: Andrew V. Schally, Ren Zhi Cai, Marta Zarandi
-
Publication number: 20130261055Abstract: There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 96) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc, Me-NH-Sub, PhAc-Ada, Ac-Ada-D-Phe, Ac-Ada-Phe, Dca-Ada, Dca-Amc, Nac-Ada, Ada-Ada, or CH3—(CH2)10—CO-Ada, at the N-Terminus and ?-Ala, Amc, Apa, Ada, AE2A, AE4P, ?-Lys(?-NH2), Agm, Lys(Oct) or Ahx, at the C-terminus. These analogs inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers, and inhibit the hyperplastic and benign proliferative disorders of various organs, through a direct effect on the cancerous and non-malignant cells. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, result from replacement of various amino acids.Type: ApplicationFiled: September 25, 2010Publication date: October 3, 2013Inventors: Andrew V. Schally, Marta Zarandi, Jozsef L. Varga, Ren Zhi Cai