Abstract: A rotor assembly for a gas turbine engine includes a shaft co-rotatable with a rotor with an annular seal assembly that is carried within an annular channel within the shaft that provides a seal between the shaft and the bore. The annular seal assembly includes a first member that is configured to seal against a radial surface of the bore and a second member that is configured to seal against an axial surface of the annular channel.

Abstract: A rotor assembly for a gas turbine engine includes a shaft co-rotatable with a rotor with an annular seal assembly that is carried within an annular channel within the shaft that provides a seal between the shaft and the bore. The annular seal assembly includes a first member that is configured to seal against a radial surface of the bore and a second member that is configured to seal against an axial surface of the annular channel.

Abstract: A gas turbine engine includes a rotor that has a seal surface and a shaft that is rotatable about an engine central axis. The shaft has an annular seal channel that opens to the seal surface. There is a seal for sealing against the seal surface. The seal has channels formed therein that define a tortuous seal wall with interconnected spring ligaments such that the seal is elastically diametrically expandable for installation clearance around the shaft and, once on the shaft, elastically diametrically collapsible into the annular seal channel.

Abstract: A system for determining rotor-dynamic orbit information including an engine case supporting at least one engine stage, each at least one engine stage including a rotor having blades; at least one blade tip sensor operatively coupled to the engine case and in operative communication with the blades; at least one compensation sensor in operative communication with the at least one blade tip sensor; and an orbit controller in operative communication with the at least one blade tip sensor and the at least one compensation sensor.

Abstract: A magnet system is provided for generating a homogeneous magnetic field in a target region that finds benefit in the field of nuclear magnetic resonance (NMR), particularly NMR spectroscopy. The magnet system comprises a first magnet having a first solenoid formed from superconductor material and a set of one or more pairs of compensation coils, each said pair being disposed coaxially with the first solenoid and symmetrically positioned with an axial offset about the geometrical centre point so as to define an annular volume within the bore between the set of compensation coils. A first pair of compensation coils in the set is connected in electrical series with the first solenoid. A shim system is disposed within the annular volume and comprising one or more superconducting shim coils. The magnetic field in the target region has a homogeneity of less than 10 parts per million, wherein the target region is a 1 cm diameter spherical volume centred on the centre point.

Abstract: A quench protection arrangement for a superconducting magnet is disclosed. The arrangement comprises: a superconducting magnet comprising a plurality of magnet sections; a plurality of varistors, wherein each of the plurality of varistors is electrically connected in parallel across a respective one of the plurality of magnet sections; and a heater arrangement electrically connected to the plurality of varistors and configured to apply heat to each of the plurality of magnet sections in response to a change in a voltage across any one or more of the plurality of varistors. A method of protecting a superconducting magnet is also disclosed.

Abstract: A quench protection arrangement for a superconducting magnet is disclosed. The arrangement comprises: a superconducting magnet comprising a plurality of magnet sections; a plurality of varistors, wherein each of the plurality of varistors is electrically connected in parallel across a respective one of the plurality of magnet sections; and a heater arrangement electrically connected to the plurality of varistors and configured to apply heat to each of the plurality of magnet sections in response to a change in a voltage across any one or more of the plurality of varistors. A method of protecting a superconducting magnet is also disclosed.

Abstract: The present invention relates to the reduction of the side-effects induced by tetrabenazine or other inhibitors of vesicular monoamine transporter (VMAT), in the treatment of central nervous system disorders such as Huntington's disease, L-DOPA-induced dyskinesias in Parkinson's disease, Tourette's syndrome or tardive dyskinesia. The invention comprises administering to a patient in need thereof an effective amount of activates selective serotonin 5-HT1A receptors agonist, whereby the side-effects of depression or Parkinsonism induced by tetrabenazine or other VMAT inhibitors are minimized.

Abstract: A fluid damping structure includes first and second annular elements, first and second inner seals, a first outer seal, a damping chamber, a supply plenum, a fill port, and a plurality of fluid passages. The first and second inner seals are disposed radially between and are engaged with the first annular element and the second annular element. The first outer seal forms a sealing interface between the first and second annular elements. The first outer seal is disposed radially outward from the first and second inner seals. The damping chamber is defined by the first and second annular elements and the first and second inner seals. The supply plenum is disposed contiguous with an axial side of the damping chamber and extends from the second inner seal to the first outer seal. The fill port is in fluid communication with the supply plenum and a source of damping fluid.

Abstract: An actively controlled squeeze film damper system comprises a housing defining an annulus receiving a damping fluid during operation, a lubricant source supplying damping fluid to the annulus, and a sensor assembly for measuring a parameter indicative of a compressibility of the damping fluid. A control device adjusts the compressibility of the damping fluid within a predefined range.

Abstract: An actively controlled squeeze film damper system comprises a housing defining an annulus receiving a damping fluid during operation, a lubricant source supplying damping fluid to the annulus, and a sensor assembly for measuring a parameter indicative of a compressibility of the damping fluid. A control device adjusts the compressibility of the damping fluid within a predefined range.

Abstract: The present invention relates to the reduction of the side-effects induced by tetrabenazine or other inhibitors of vesicular monoamine transporter (VMAT), in the treatment of central nervous system disorders such as Huntington's disease, L-DOPA-induced dyskinesias in Parkinson's disease, Tourette's syndrome or tardive dyskinesia.

Abstract: A bearing assembly includes a bearing housing having a first bearing housing surface and a second bearing housing surface. The bearing housing surfaces are substantially axially parallel. A the first bearing housing surface has a first and second piston ring groove with a corresponding piston ring in each groove. A damper includes a first outer surface radially adjacent to and opposing the first bearing housing surface and a second outer surface radially adjacent to and opposing the second bearing housing surface. The second outer surface includes a third and fourth piston ring groove with a corresponding piston ring disposed in each groove. The bearing housing includes a damping fluid passage configured to provide damping fluid to a gap radially between the first outer surface and the first bearing housing surface and to a gap radially between the second outer surface and the second bearing housing surface.

Abstract: The invention concerns compounds that possess a high affinity at 5-HT1A receptors and an agonist efficacy, as measured by Emax values from a cellular activation assay, that is higher than that of the compounds described in prior art. The capacity of the compounds of the invention to activate an effector protein complex is higher than that the most efficacious agonist described in prior art. Compounds of the invention also exhibit an exceptionally high selectivity (Ki ratio greater than 1000-fold) with respect, in particular, to dopamine D2 receptors and adrenergic receptors of the alpha1 subtype. This selectivity which constitutes a great advantage since it means that the compounds will avoid inducing (central and peripheral) effects associated with activating or inhibiting such receptors.

Abstract: A bearing assembly includes a case, a bearing spring positioned inside the case, a first seal positioned between the case and the bearing spring, and a second seal. The a second seal is positioned between the case and the bearing spring and is spaced apart from the first seal, wherein the second seal is an adjustable seal that is movable between a closed position and an opened position to inhibit or allow, respectively, a fluid to flow from a cavity that is defined by the case, the bearing spring, the first seal and the second seal.

Abstract: The invention concerns compounds that possess a high affinity at 5-HT1A receptors and an agonist efficacy, as measured by Emax values from a cellular activation assay, that is higher than that of the compounds described in prior art. The capacity of the compounds of the invention to activate an effector protein complex is higher than that the most efficacious agonist described in prior art. Compounds of the invention also exhibit an exceptionally high selectivity (Ki ratio greater than 1000-fold) with respect, in particular, to dopamine D2 receptors and adrenergic receptors of the alpha1 subtype. This selectivity which constitutes a great advantage since it means that the compounds will avoid inducing (central and peripheral) effects associated with activating or inhibiting such receptors.

Abstract: A bearing assembly includes a case, a bearing spring positioned inside the case, a first seal positioned between the case and the bearing spring, and a second seal. The a second seal is positioned between the case and the bearing spring and is spaced apart from the first seal, wherein the second seal is an adjustable seal that is movable between a closed position and an opened position to inhibit or allow, respectively, a fluid to flow from a cavity that is defined by the case, the bearing spring, the first seal and the second seal.

Abstract: A superconducting magnet system comprises a cryogenic vessel (1), a superconducting magnet (11) contained in an inner reservoir (16) within the vessel (1) to be cooled by liquid helium within the inner reservoir (16), and an outer reservoir (7) containing liquid helium and linked to the inner reservoir (16) by a feed tube (10) and a needle valve (9). In operation of the system current is supplied to the magnet (11) by a removable current lead (19) extending through the wall of the vessel (1) by way of a supply passage (17) in order to initiate superconducting current flow in the magnet. The supply of current to the magnet (11) is then stopped and the lead (19) is removed whilst the superconducting current flow persists in the magnet. After an extended period of superconducting current flow in the magnet (11) and without stopping such superconducting current flow, liquid helium at a temperature of about 4.

Abstract: A compound of formula I wherein X represents an optionally halo-substituted (C2-4)alkynylene group bonded via vicinal unsaturated carbon atoms.

Abstract: The invention provides the use of selective mGluR5 antagonists for the treatment of pain and anxiety, and the use of mGluR antagonists for the treatment of pain, whereby analgesic effect is achieved by interaction of said antagonists primarily or predominantly at peripheral mGluR receptors.