Patents by Inventor Andrew W. Fraley

Andrew W. Fraley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA-editing oligonucleotides and uses thereof
    Patent number: 12031131
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result.
    Type: Grant
    Filed: May 3, 2023
    Date of Patent: July 9, 2024
    Assignee: KORRO BIO, INC.
    Inventors: Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
  • MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
    Publication number: 20240165267
    Abstract: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
    Type: Application
    Filed: November 23, 2022
    Publication date: May 23, 2024
    Inventors: Atanu ROY, Christopher R. CONLEE, Antonin DE FOUGEROLLES, Andrew W. FRALEY
  • RNA-Editing Oligonucleotides and Uses Thereof
    Publication number: 20230340464
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result.
    Type: Application
    Filed: May 3, 2023
    Publication date: October 26, 2023
    Applicant: Korro Bio, Inc.
    Inventors: Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
  • RNA-Editing Oligonucleotides and Uses Thereof
    Publication number: 20230332143
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
    Type: Application
    Filed: May 9, 2023
    Publication date: October 19, 2023
    Applicant: Korro Bio, Inc.
    Inventors: Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
  • POLYNUCLEOTIDES CONTAINING A MORPHOLINO LINKER
    Publication number: 20230323344
    Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.
    Type: Application
    Filed: September 6, 2022
    Publication date: October 12, 2023
    Inventors: Gabor BUTORA, Andrew W. Fraley, Edward John Miracco, Jennifer Nelson, Amy Rhoden Smith, Matthew Stanton
  • RNA-Editing Oligonucleotides and Uses Thereof
    Publication number: 20230146891
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
    Type: Application
    Filed: September 15, 2022
    Publication date: May 11, 2023
    Applicant: Korro Bio, Inc.
    Inventors: Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
  • RNA-Editing Oligonucleotides and Uses Thereof
    Publication number: 20230104978
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result,
    Type: Application
    Filed: August 5, 2022
    Publication date: April 6, 2023
    Applicant: Korro Bio, Inc.
    Inventors: Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
  • RNA-editing oligonucleotides and uses thereof
    Patent number: 11479575
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: October 25, 2022
    Assignee: Korro Bio, Inc.
    Inventors: Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
  • RNA-editing oligonucleotides and uses thereof
    Patent number: 11453878
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: September 27, 2022
    Assignee: Korro Bio, Inc.
    Inventors: Andrew W. Fraley, Steven Robinette, Nessan Bermingham, Mallikarjuna Reddy Putta
  • Polynucleotides containing a morpholino linker
    Patent number: 11434486
    Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: September 6, 2022
    Assignee: ModernaTX, Inc.
    Inventors: Gabor Butora, Andrew W. Fraley, Edward John Miracco, Jennifer Nelson, Amy Rhoden Smith, Matthew Stanton
  • RNA-EDITING OLIGONUCLEOTIDES AND USES THEREOF
    Publication number: 20200399303
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
    Type: Application
    Filed: January 22, 2020
    Publication date: December 24, 2020
    Inventors: Andrew W. FRALEY, Steven ROBINETTE, Nessan BERMINGHAM, Mallikarjuna Reddy PUTTA
  • RNA-EDITING OLIGONUCLEOTIDES AND USES THEREOF
    Publication number: 20200392486
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
    Type: Application
    Filed: January 22, 2020
    Publication date: December 17, 2020
    Inventors: Andrew W. FRALEY, Steven ROBINETTE, Nessan BERMINGHAM, Mallikarjuna Reddy PUTTA
  • RNA-EDITING OLIGONUCLEOTIDES AND USES THEREOF
    Publication number: 20200385713
    Abstract: The present disclosure features useful compositions and methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
    Type: Application
    Filed: January 22, 2020
    Publication date: December 10, 2020
    Inventors: Andrew W. FRALEY, Steven ROBINETTE, Nessan BERMINGHAM, Mallikarjuna Reddy PUTTA
  • Circular polynucleotides
    Patent number: 10407683
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: September 10, 2019
    Assignee: ModernaTX, Inc.
    Inventors: Jennifer Nelson, Andrew W. Fraley, Amy Rhoden Smith
  • ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
    Publication number: 20190255194
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
    Type: Application
    Filed: March 1, 2019
    Publication date: August 22, 2019
    Inventors: Atanu ROY, Christopher R. CONLEE, Antonin DE FOUGEROLLES, Andrew W. FRALEY, Gabor BUTORA, Matthew STANTON
  • Polynucleotide molecules and uses thereof
    Patent number: 10385088
    Abstract: The present disclosure provides alternative sugar moieties and polynucleotides comprising such sugar moieties, and methods of use thereof.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: August 20, 2019
    Assignee: ModernaTX, Inc.
    Inventors: Andrew W. Fraley, Atanu Roy, Matthew Stanton
  • Alternative nucleic acid molecules and uses thereof
    Patent number: 10286086
    Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: May 14, 2019
    Assignee: ModernaTX, Inc.
    Inventors: Atanu Roy, Christopher R. Conlee, Antonin De Fougerolles, Andrew W. Fraley, Gabor Butora, Matthew Stanton
  • POLYNUCLEOTIDES CONTAINING A MORPHOLINO LINKER
    Publication number: 20190078087
    Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.
    Type: Application
    Filed: September 19, 2016
    Publication date: March 14, 2019
    Inventors: Gabor BUTORA, Andrew W. FRALEY, Edward John MIRACCO, Jennifer NELSON, Amy RHODEN-SMITH, Matthew STANTON
  • POLYNUCLEOTIDES CONTAINING A STABILIZING TAIL REGION
    Publication number: 20180256750
    Abstract: The invention features polynucleotides encoding a polypeptide including a 3?-stabilizing region and having increased stability compared to wild-type polynucleotides.
    Type: Application
    Filed: September 19, 2016
    Publication date: September 13, 2018
    Applicant: MODERNA THERAPEUTICS, INC.
    Inventors: Gabor BUTORA, Andrew W. FRALEY, Edward John MIRACCO, Jennifer NELSON, Amy RHODEN-SMITH, Matthew STANTON
  • CHIMERIC POLYNUCLEOTIDES
    Publication number: 20170204152
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules, which allow for customized placement, position and percent load of chemical modifications, which improve, alter or optimize certain physicochemical and pharmaceutical properties of the polynucleotides. In one non-limiting embodiment, such chimeric polynucleotides take the form or function as modified mRNA molecules which encode a polypeptide of interest. In one embodiment, such chimeric polynucleotides are substantially noncoding.
    Type: Application
    Filed: July 16, 2015
    Publication date: July 20, 2017
    Applicant: Moderna Therapeutics, Inc.
    Inventors: Jennifer NELSON, Andrew W. FRALEY, Amy RHODEN-SMITH