Patents by Inventor Andrew W. Hinman

Andrew W. Hinman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING ALPHA-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS
    Publication number: 20230339835
    Abstract: Disclosed herein are methods of treating or suppressing a disorder selected from the group consisting of ?-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.ury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula: or the hydroquinone form thereof; or a solvate or hydrate thereof.
    Type: Application
    Filed: July 5, 2023
    Publication date: October 26, 2023
    Inventors: Andrew W. Hinman, Charles R. Holst, Angela Minnella, Paul Mollard, Sean Pintchovski, Jeffrey K. Trimmer, Eric Torrey
  • 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating alpha-synucleinopathies, tauopathies, and other disorders
    Patent number: 11746077
    Abstract: Disclosed herein are methods of treating or suppressing a disorder selected from the group consisting of ?-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.ury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula: or the hydroquinone form thereof; or a solvate or hydrate thereof.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: September 5, 2023
    Assignee: PTC Therapeutics, Inc.
    Inventors: Andrew W. Hinman, Charles R. Holst, Angela Minnella, Paul Mollard, Sean Pintchovski, Jeffrey K. Trimmer, Eric Torrey
  • Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
    Patent number: 11680034
    Abstract: Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: June 20, 2023
    Assignee: PTC Therapeutics, Inc.
    Inventors: Andrew W. Hinman, Steven J. Richards
  • 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating alpha-synucleinopathies, tauopathies, and other disorders
    Patent number: 11667596
    Abstract: Disclosed herein are methods of treating or suppressing a disorder selected from the group consisting of ?-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.ury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula: or the hydroquinone form thereof; or a solvate or hydrate thereof.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: June 6, 2023
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Andrew W. Hinman, Charles R. Holst, Angela Minnella, Paul Mollard, Sean Pintchovski, Jeffrey K. Trimmer, Eric Torrey
  • METHODS AND COMPOSITIONS FOR TREATMENT OF INFLAMMATION AND OXIDATIVE STRESS
    Publication number: 20220257533
    Abstract: Compounds, compositions, and methods for treatment of, or prophylaxis against, inflammation and/or oxidative stress are disclosed.
    Type: Application
    Filed: November 29, 2021
    Publication date: August 18, 2022
    Inventors: Guy M. MILLER, Jeffery K. TRIMMER, William SHRADER, Andrew W. HINMAN, Charles R. HOLST, Joey C. LATHAM, Joel J. BRUEGGER, Kevin P. MCCUSKER, Gözde ULAS, Dana DAVIS, Amanda H. KAHN-KIRBY, Edgar P. LEE, Stephanie A. MALONE, Steven J. RICHARDS, Matthew B. KLEIN
  • 2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING ALPHA-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS
    Publication number: 20220220054
    Abstract: Disclosed herein are methods of treating or suppressing a disorder selected from the group consisting of ?-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.ury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula: or the hydroquinone form thereof; or a solvate or hydrate thereof.
    Type: Application
    Filed: January 25, 2022
    Publication date: July 14, 2022
    Inventors: Andrew W. Hinman, Charles R. Holst, Angela Minnella, Paul Mollard, Sean Pintchovski, Jeffrey K. Trimmer, Eric Torrey
  • PROCESS FOR THE PRODUCTION OF ALPHA-TOCOTRIENOL AND DERIVATIVES
    Publication number: 20220204469
    Abstract: The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.
    Type: Application
    Filed: March 18, 2022
    Publication date: June 30, 2022
    Inventors: Kieron E. WESSON, Andrew W. Hinman, Orion D. Jankowski
  • Process for the production of alpha-tocotrienol and derivatives
    Patent number: 11312697
    Abstract: The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: April 26, 2022
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Kieron E. Wesson, Andrew W. Hinman, Orion D. Jankowski
  • 2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING ALPHA-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS
    Publication number: 20220106248
    Abstract: Disclosed herein are methods of treating or suppressing a disorder selected from the group consisting of ?-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.ury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula: or the hydroquinone form thereof; or a solvate or hydrate thereof.
    Type: Application
    Filed: November 10, 2021
    Publication date: April 7, 2022
    Inventors: Andrew W. Hinman, Charles R. Holst, Angela Minnella, Paul Mollard, Sean Pintchovski, Jeffrey K. Trimmer, Eric Torrey
  • 2,3,5-trimelthyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating alpha-synucleinopathies, tauopathies, and other disorders
    Patent number: 11174212
    Abstract: Disclosed herein are methods of treating or suppressing a disorder selected from the group consisting of ?-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.ury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula: or the hydroquinone form thereof; or a solvate or hydrate thereof.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: November 16, 2021
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Andrew W. Hinman, Charles R. Holst, Angela Minnella, Paul Mollard, Sean Pintchovski, Jeffrey K. Trimmer, Eric Torrey
  • 2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING ALPHA-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS
    Publication number: 20210276937
    Abstract: Disclosed herein are methods of treating or suppressing a disorder selected from the group consisting of ?-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.ury, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula: or the hydroquinone form thereof; or a solvate or hydrate thereof.
    Type: Application
    Filed: March 30, 2021
    Publication date: September 9, 2021
    Inventors: Andrew W. Hinman, Charles R. Holst, Angela Minella, Paul Mollard, Sean Pintchovski, Jeffrey K. Trimmer, Eric Torrey
  • FLUOROALKYL, FLUOROALKOXY, PHENOXY, HETEROARYLOXY, ALKOXY, AND AMINE 1,4-BENZOQUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS
    Publication number: 20210238119
    Abstract: Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.
    Type: Application
    Filed: April 12, 2021
    Publication date: August 5, 2021
    Inventors: Andrew W. Hinman, Steven J. Richards
  • Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
    Patent number: 10981855
    Abstract: Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: April 20, 2021
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Andrew W. Hinman, Steven J. Richards
  • FLUOROALKYL, FLUOROALKOXY, PHENOXY, HETEROARYLOXY, ALKOXY, AND AMINE 1,4-BENZOQUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS
    Publication number: 20200331835
    Abstract: Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.
    Type: Application
    Filed: July 6, 2020
    Publication date: October 22, 2020
    Inventors: Andrew W. HINMAN, Steven J. RICHARDS
  • Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
    Patent number: 10703701
    Abstract: Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.
    Type: Grant
    Filed: December 17, 2016
    Date of Patent: July 7, 2020
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Andrew W. Hinman, Steven J. Richards
  • METHODS AND COMPOSITIONS FOR TREATMENT OF INFLAMMATION AND OXIDATIVE STRESS
    Publication number: 20200121618
    Abstract: Compounds, compositions, and methods for treatment of, or prophylaxis against, inflammation and/or oxidative stress are disclosed.
    Type: Application
    Filed: April 14, 2018
    Publication date: April 23, 2020
    Inventors: Guy M. MILLER, Jeffery K. TRIMMER, William D. SHRADER, Andrew W. HINMAN, Charles R. HOLST, Joey C. LATHAM, Joel J. BRUEGGER, Kevin P. MCCUSKER, Gozde ULAS, Dana DAVIS, Amanda H. KAHN-KIRBY, Edgar P. LEE, Stephanie A. MALONE, Steven J. RICHARDS, Matthew B. KLEIN
  • Resorcinol compounds for dermatological use
    Patent number: 10470986
    Abstract: Provided herein are methods and compositions comprising resorcinol derivatives for the use of treating, regulating or preventing a skin condition characterized by oxidative stress or a degenerative process. Methods of preventing, lightening or reducing the appearance of visible discontinuities of the skin resulting from skin pigmentation, skin aging, or other disorders are also disclosed.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: November 12, 2019
    Assignee: Conopco, Inc.
    Inventors: Andrew W Hinman, Dana Davis, Viktoria Kheifets
  • METHODS FOR ANALYZING P-HYDROQUINONE LEVELS AND RATIOS
    Publication number: 20190241497
    Abstract: Provided herein are compounds and methods of using the compounds for determining levels of, for example, para-hydroquinones in a sample.
    Type: Application
    Filed: October 27, 2017
    Publication date: August 8, 2019
    Inventor: Andrew W. HINMAN
  • Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders
    Patent number: 10189830
    Abstract: Disclosed herein are alkyl-heteroaryl substituted quinone derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 29, 2019
    Assignee: BIOELECTRON TECHNOLOGY CORPORATION
    Inventors: Andrew W. Hinman, Kieron E. Wesson, Christopher R. Cornell
  • PROCESS FOR THE PRODUCTION OF ALPHA-TOCOTRIENOL AND DERIVATIVES
    Publication number: 20190002428
    Abstract: The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.
    Type: Application
    Filed: September 10, 2018
    Publication date: January 3, 2019
    Inventors: Kieron W. WESSON, Andrew W. HINMAN, Orion D. JANKOWSKI