Patents by Inventor Andrew W. Lloyd

Andrew W. Lloyd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Drug carriers comprising amphilphilic block copolymers
    Patent number: 9765213
    Abstract: An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug. The hydrophilic block is preferably formed from acrylic monomer including phosphorylcholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form. The preformed micelles are then contacted with active, under conditions such that solubilisation of the active occurs. The active may be for tumour treatment.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: September 19, 2017
    Assignee: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Leonard Lewis, Steven Peter Armes, Andrew W. Lloyd, Jonathan P. Salvage
  • DRUG CARRIERS COMPRISING AMPHILPHILIC BLOCK COPOLYMERS
    Publication number: 20120157550
    Abstract: An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug. The hydrophilic block is preferably formed from acrylic monomer including phosphorylcholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form. The preformed micelles are then contacted with active, under conditions such that solubilisation of the active occurs. The active may be for tumour treatment.
    Type: Application
    Filed: January 23, 2012
    Publication date: June 21, 2012
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard LEWIS, Steven Peter ARMES, Andrew W. LLOYD, Jonathan P. SALVAGE
  • Phospholipid-coated implants
    Patent number: 6863693
    Abstract: A prosthesis or implant has a surface carrying a coating comprising at least one phospholipid at a concentration to improve osteointegration. A method of making such a prosthesis or implant and a kit comprising a prosthesis or implant is also described.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: March 8, 2005
    Assignees: Destiny Pharma Limited, University of Brighton
    Inventors: Andrew W. Lloyd, Matteo Santin, Stephen P. Denyer, William Rhys-Williams, William G. Love
  • Phospholipid-coated implants
    Publication number: 20020165617
    Abstract: A prosthesis or implant has a surface carrying a coating comprising at least one phospholipid at a concentration to improve osteointegration. A method of making such a prosthesis or implant and a kit comprising a prosthesis or implant is also described.
    Type: Application
    Filed: February 28, 2002
    Publication date: November 7, 2002
    Applicant: DESTINY PHARMA LIMITED
    Inventors: Andrew W. Lloyd, Matteo Santin, Stephen P. Denyer, William Rhys-Williams, William G. Love