Abstract: Methods and systems for generating physiological metrics for display on a computing device are disclosed herein. In some implementations, an exemplary system comprises a torso wearable device including a wireless transmitter and a sensor, and non-transitory computer-readable media (CRM). The CRM, when executed by a computing device in communication with the wireless transmitter, can perform operations comprising: receiving the input signals representing respiration of the user; displaying a graphical user interface to the user; receiving one or more user inputs associated with a desired metric; displaying on the graphical user interface a first visualization corresponding to the desired metric; and displaying on the graphical user interface a second visualization corresponding to a physiological metric based on the input signals generated from the sensor. The second visualization can change in real time based on real time angular displacement of the sensor in response to the respiration of the user.

Abstract: Aspects of the disclosure relate to models for estimating the likelihood of fatigue in test drivers. In some instances, training data including videos of the test drivers while such test drivers are tasked with monitoring driving of a vehicle operating in an autonomous driving mode may be identified. The training data also includes driver drowsiness values generated from one or more human operators observing the videos. The training inputs and outputs may be used to train the model such that when a new video of a first test driver is input into the model, the model will output an estimate of a likelihood of fatigue for that test driver.

Abstract: A nanoparticle activity sensor containing a reporter and at least one tuning domain that modifies a distribution or residence time of the activity sensor when administered to a patient. When administered to the patient, the activity sensor enters cells or tissue where it is cleaved by enzymes specific to a physiological state such as a disease to release a detectable analyte. The tuning domains include molecular structures that modulate distribution or decay by protecting the particle from premature cleavage and indiscriminate hydrolysis, shielding the particle from immune detection and clearance, or by targeting the particle to specific tissue, bodily fluids, or cell types.

Abstract: Electronic headphones that are operational when worn or placed on the head of a wearer and are non-operational when the electronic headphones are not worn. In exemplary embodiments, one or more sensors in the electronic headphones may detect this change of position of the earcups/pivot arms of the headset which indicates the wearer is no longer wearing the electronic headphones and put the electronic headphones in a non-operational state. Correspondingly, when placed on the head of a wearer, the sensor(s) detect the change of position of the electronic headphones which indicates the wearer is wearing the electronic headphones and puts the electronic headphones in an operational state.

Abstract: Described herein are systems and methods for abstracted analysis system design for a dynamic API scanning service. The disclosure provides a simplified API scanning service by abstracting underlining security scanning techniques and configurations. This presents a normalized view to users of the service. Both input parameters and scan output data is abstracted from users, and is driven based on logic in the service. By providing this simplified view, users can quickly, and without prior security scanning knowledge, use this service to measure their security exposure and mitigate as needed.

Abstract: An electronic headphone set including a pair of ear cups with a head band interconnecting the ear cups. At least one of the ear cups is movable between a usable position and an unusable position, and electronic circuitry is operably connected to the ear cups. A switch operably interconnects at least one ear cup to the head band and is operable to enable the electronic circuitry when in the usable position and to disable the electronic circuitry when in the unusable position.

Abstract: Methods and compositions for screening or diagnosis of liver disease are provided. The results may also indicate course and efficacy of treatment. The composition includes an activity sensor and a reporter releasably attached to the activity sensor. The method includes detecting the presence and/or amount of a reporter. The reporter is released from an activity sensor in the presence of diseased liver tissue but remains attached to the activity sensor in healthy tissue. The presence and/or amount of the reporter are used to characterize the liver disease. The liver disease may be nonalcoholic steatohepatitis (NASH) and results may further indicate staging of NASH.

Abstract: Aspects of the disclosure relate to models for estimating the likelihood of fatigue in test drivers. In some instances, training data including videos of the test drivers while such test drivers are tasked with monitoring driving of a vehicle operating in an autonomous driving mode may be identified. The training data also includes driver drowsiness values generated from one or more human operators observing the videos. The training inputs and outputs may be used to train the model such that when a new video of a first test driver is input into the model, the model will output an estimate of a likelihood of fatigue for that test driver.

Abstract: In an example implementation according to aspects of the present disclosure, a method may include detecting, by a computing device, termination of a wired connection via a connector, after a module is detached from a cavity of the computing device, and automatically switching from the wired connection to a wireless connection between the module and the computing device, to maintain the data communications between the module and the computing device.

Abstract: Methods and compositions for screening or diagnosis of liver disease are provided. The results may also indicate course and efficacy of treatment. The composition includes an activity sensor and a reporter releasably attached to the activity sensor. The method includes detecting the presence and/or amount of a reporter. The reporter is released from an activity sensor in the presence of diseased liver tissue but remains attached to the activity sensor in healthy tissue. The presence and/or amount of the reporter are used to characterize the liver disease. The liver disease may be nonalcoholic steatohepatitis (NASH) and results may further indicate staging of NASH.

Abstract: A system for verifying a request for access to data is provided, the system comprising a first module 20 and a second module 30. The first module 20 is arranged to generate a password, and the second module 30 is arranged to receive a password associated with a request for data, validate the received password, and enable access to the requested data. The system is such that the first and second modules 20, 30 share a secret that has been uniquely assigned thereto, the shared secret being for use in generation and validation of a said password. Furthermore, the first module 20 is communicatively disconnected from the second module 30.

Abstract: Described herein are systems and methods for abstracted analysis system design for a dynamic API scanning service. The disclosure provides a simplified API scanning service by abstracting underlining security scanning techniques and configurations. This presents a normalized view to users of the service. Both input parameters and scan output data is abstracted from users, and is driven based on logic in the service. By providing this simplified view, users can quickly, and without prior security scanning knowledge, use this service to measure their security exposure and mitigate as needed.

Abstract: The present invention provides method for longitudinal monitoring of disease changes and/or drug response. At multiple time points, a composition is introduced into a body of a subject (the composition includes an activity sensor comprising a plurality of reporters liberated through enzymatic cleavage, which occurs in a tissue of the body when enzymes associated with known activity of a therapeutic intervention are present in the body) and reporters are detected to determine activity levels of disease-associated enzymes in the subject, which is correlated to changes in disease state and/or drug response. A report or therapeutic response profile may further be used to support a clinical trial and for longitudinal monitoring of disease progression or regression in a subject. A prospective or active clinical trial participant, or patient undergoing treatment, may be qualified, stratified or staged based on the determined activity levels.

Abstract: Embodiments relate to methods and systems for analyzing genomic data, such as genetic variants. Some embodiments relate to the efficient analysis and presentation of certain genetic variants of an individual.

Abstract: Methods of the disclosure provide an analytical pipeline for mapping activity in a disease-specific manner. Any of a variety of diseases or medical conditions may be mapped using the analytical pipeline. In preferred embodiments, the pipeline uses expression data (e.g., from RNA-Seq) to identify proteases that are active in disease tissue and subject to differential expression relative to normal tissue. A machine learning classifier selects a subset of the proteases that identify the disease with a threshold sensitivity and specificity, in which the subset is small enough that a corresponding set of protease substrates may be assembled into a nanoparticle activity sensor that, when administered to a patient, are cleaved in the presence of disease tissue to release detectable analytes signifying presence of the disease.

Abstract: A nanoparticle activity sensor containing a reporter and at least one tuning domain that modifies a distribution or residence time of the activity sensor when administered to a patient. When administered to the patient, the activity sensor enters cells or tissue where it is cleaved by enzymes specific to a physiological state such as a disease to release a detectable analyte. The tuning domains include molecular structures that modulate distribution or decay by protecting the particle from premature cleavage and indiscriminate hydrolysis, shielding the particle from immune detection and clearance, or by targeting the particle to specific tissue, bodily fluids, or cell types.

Abstract: Methods and compositions for screening or diagnosis of liver disease are provided. The results may also indicate course and efficacy of treatment. The composition includes an activity sensor and a reporter releasably attached to the activity sensor. The method includes detecting the presence and/or amount of a reporter. The reporter is released from an activity sensor in the presence of diseased liver tissue but remains attached to the activity sensor in healthy tissue. The presence and/or amount of the reporter are used to characterize the liver disease. The liver disease may be nonalcoholic steatohepatitis (NASH) and results may further indicate staging of NASH.