Abstract: The present disclosure provides methods for treating a subject having a HER2 non-amplified (HER2-negative) cancer or low HER2 expressing (HER2-low) cancer, comprising detecting expression of a BCAR4 gene fusion in a biological sample from the subject. If expression of the BCAR4 gene fusion is detected, a HER2-targeted cancer treatment is administered to the subject; if expression of the BCAR4 gene fusion is not detected, a cancer treatment that is not HER2-targeted is administered to the subject. Methods of predicting response to a HER2-targeted cancer treatment and detecting BCAR4 or BCAR4 gene fusion activation are also provided.

Abstract: A method of generating a consolidated asset inventory database. The method creates a consolidated asset inventory based on asset information obtained from various sources, in which asset objects are associated with various asset attributes. The consolidation includes, for a given network infrastructure asset, identifying asset data from multiple sources relating to the same asset based on common identifier values and combining the identified asset data into a consolidated data representation of the asset associated with the common identifier value(s) and including attributes from the multiple sources. After identifying an asset attribute for which a value in the consolidated asset data representation is missing or invalid, a trained prediction model is applied to other attributes of the asset to generate a predicted value for the identified attribute which is stored in the consolidated asset data representation in the database.

Abstract: A bicycle frame including a front portion configured to receive a front wheel assembly; a rear portion configured to receive a rear wheel assembly; and a connecting member connected to the front portion at a first connecting point and connected to the rear portion at a second connecting point, the first and second connecting points being spaced from one another along the length of the connecting member; wherein one of the front and rear portions extends towards and is connected to the other of the front and rear portions at a third connecting point to form a link; wherein the frame is configured so as to allow a distance between at least two of the connecting points to be adjusted; wherein adjustment of said distance increases or decreases the size of the frame.

Abstract: A method of protecting an ocular surface is provided. The method includes administering to a patient in need thereof an effective amount of a pharmaceutical composition administered in an amount effective to prevent uptake of fluorescein dye and/or rose-bengal dye.

Abstract: A bicycle frame including a front portion configured to receive a front wheel assembly; a rear portion configured to receive a rear wheel assembly; and a connecting member connected to the front portion at a first connecting point and connected to the rear portion at a second connecting point, the first and second connecting points being spaced from one another along the length of the connecting member; wherein one of the front and rear portions extends towards and is connected to the other of the front and rear portions at a third connecting point to form a link; wherein the frame is configured so as to allow a distance between at least two of the connecting points to be adjusted; wherein adjustment of said distance increases or decreases the size of the frame.

Abstract: Embodiments presented in this disclosure generally relate to an electro-optic device that includes one or more modulator portions and a terminator portion. Each modulator portion is disposed along a propagation path of an optical signal and includes a respective first doped region and one or more coupled first electrical contacts. Each modulator portion operates to modulate an optical signal propagating through the first doped region using first electrical signals applied to the electrical contacts. The terminator portion is disposed along the propagation path and proximate to at least one modulator portions, and operates to mitigate effects of droop on the propagating optical signal.

Abstract: A Fabry-Perot etalon is provided with first and second partially reflecting mirrors (12, 14) attached to a cuboidal spacer (16). The spacer (16) has a cylindrical bore (18) through its center and the mirrors (12, 14) are bonded, on axis, to opposite ends of this bore (18). Four support elements (22-28) are arranged symmetrically with respect to the axis in a tetrahedral configuration and constrain the cuboidal spacer (16) in all degrees of freedom. The cuboidal spacer (16) is flattened at its vertices, which results in modified distortion of the spacer (16) under the action of a compressive force acting through the supports. This structure of etalon provides insensitivity to inertial forces due to acceleration in all six degrees of freedom (three linear and three rotational) simultaneously with insensitivity to differential forces.

Abstract: Embodiments presented in this disclosure generally relate to an electro-optic device that includes one or more modulator portions and a terminator portion. Each modulator portion is disposed along a propagation path of an optical signal and includes a respective first doped region and one or more coupled first electrical contacts. Each modulator portion operates to modulate an optical signal propagating through the first doped region using first electrical signals applied to the electrical contacts. The terminator portion is disposed along the propagation path and proximate to at least one modulator portions, and operates to mitigate effects of droop on the propagating optical signal.

Abstract: A beta radiation monitor (70,90), comprising a gas flow proportional detector (60) for detecting beta radiation emitted by a beta emitter external to the detector; a fill gas supply (51) configured to supply a fill gas to the detector, wherein the fill gas comprises nitrogen; a temperature sensor (72) for measuring temperature; and a controller (64) in communication with the temperature sensor for adjusting an operational parameter of the monitor in accordance with the measured temperature. The operational parameter may comprise a voltage applied across the fill gas, which may be thermistor controlled, or a beta radiation detection threshold of the detector. The fill gas is supplied by a nitrogen generator. The gas flow proportional detector may be a large-area detector.

Abstract: A Fabry-Perot etalon is provided with first and second partially reflecting mirrors (12, 14) attached to a cuboidal spacer (16). The spacer (16) has a cylindrical bore (18) through its centre and the mirrors (12, 14) are bonded, on axis, to opposite ends of this bore (18). Four support elements (22-28) are arranged symmetrically with respect to the axis in a tetrahedral configuration and constrain the cuboidal spacer (16) in all degrees of freedom. The cuboidal spacer (16) is flattened at its vertices, which results in modified distortion of the spacer (16) under the action of a compressive force acting through the supports. This structure of etalon provides insensitivity to inertial forces due to acceleration in all six degrees of freedom (three linear and three rotational) simultaneously with insensitivity to differential forces.

Abstract: A beta radiation monitor (70,90), comprising a gas flow proportional detector (60) for detecting beta radiation emitted by a beta emitter external to the detector; a fill gas supply (51) configured to supply a fill gas to the detector, wherein the fill gas comprises nitrogen; a temperature sensor (72) for measuring temperature; and a controller (64) in communication with the temperature sensor for adjusting an operational parameter of the monitor in accordance with the measured temperature. The operational parameter may comprise a voltage applied across the fill gas, which may be thermistor controlled, or a beta radiation detection threshold of the detector. The fill gas is supplied by a nitrogen generator. The gas flow proportional detector may be a large-area detector.

Abstract: A modem to modem communication system supports call waiting services by exchanging hold request and acknowledge signals before relinquishing the line servicing incoming calls. Thereafter, the modem to modem session is reestablished without having to redial. The hold request may be denied or accepted, and may define the duration a modem will hold before hanging up. The holding modem maintains the session by fooling the higher protocol layers, making them believe that the modem is not on hold. Three-way calling services are also used to free up the shared line for outgoing calls while maintaining the session with holding modems. A table may be employed to screen incoming calls through a comparison of the caller ID information with that in the table. The table may be within the modem or the host computer.

Abstract: A modem to modem communication system supports call waiting services by exchanging hold request and acknowledge signals before relinquishing the line servicing incoming calls. Thereafter, the modem to modem session is reestablished without having to redial. The hold request may be denied or accepted, and may define the duration a modem will hold before hanging up. The holding modem maintains the session by fooling the higher protocol layers, making them believe that the modem is not on hold. Three-way calling services are also used to free up the shared line for outgoing calls while maintaining the session with holding modems. A table may be employed to screen incoming calls through a comparison of the caller ID information with that in the table. The table may be within the modem or the host computer.

Abstract: A modem to modem communication system supports call waiting services by exchanging hold request and acknowledge signals before relinquishing the line servicing incoming calls. Thereafter, the modem to modem session is reestablished without having to redial. The hold request may be denied or accepted, and may define the duration a modem will hold before hanging up. The holding modem maintains the session by fooling the higher protocol layers, making them believe that the modem is not on hold. Three-way calling services are also used to free up the shared line for outgoing calls while maintaining the session with holding modems. A table may be employed to screen incoming calls through a comparison of the caller ID information with that in the table. The table may be within the modem or the host computer.

Abstract: The present invention facilitates utilization of flexible and efficient power savings in graphics systems. A graphics power management method loads a first set of graphics commands from a CPU into a GPU at the beginning of a frame cycle. The CPU is put into a power saving mode after the loading is complete. The GPU processes the commands and forwards the results to a graphics buffer. The display begins the presentation of the data at the beginning of the following refresh cycle. The CPU leaves the power savings mode at end of the frame cycle to begin loading a second set of commands. The CPU recognizes the end of the frame cycle by counting a predetermined number of frame flip interrupt requests. After the CPU counts the predetermined number of frame flip interrupt requests the CPU begins to communicate additional graphics commands and then returns to the power savings mode.

Abstract: A modem to modem communication system supports call waiting services by exchanging hold request and acknowledge signals before relinquishing the line servicing incoming calls. Thereafter, the modem to modem session is reestablished without having to redial. The hold request may be denied or accepted, and may define the duration a modem will hold before hanging up. The holding modem maintains the session by fooling the higher protocol layers, making them believe that the modem is not on hold. Three-way calling services are also used to free up the shared line for outgoing calls while maintaining the session with holding modems. A table may be employed to screen incoming calls through a comparison of the caller ID information with that in the table. The table may be within the modem or the host computer.

Abstract: A method of replacing a damaged blade (12A) of an integrally bladed rotor assembly (10) including a disc (14) and a plurality of blades (12) extending outwardly from the disc (14) includes the steps of; removing the damaged blade (12A) to leave a blade stub (16) projecting from the disc (14); depositing a collar (22) of metal around the blade stub (16) at a position physically separated from the disc (14); attaching a replacement blade (12B) to the stub (16) by linear friction welding; and removing the collar (22). A body (20) of a material may be deposited between the disc (14) and the collar (22) to protect the disc (14) from damage.

Abstract: A modem to modem communication system supports call waiting services by exchanging hold request and acknowledge signals before relinquishing the line servicing incoming calls. Thereafter, the modem to modem session is reestablished without having to redial. The hold request may be denied or accepted, and may define the duration a modem will hold before hanging up. The holding modem maintains the session by fooling the higher protocol layers, making them believe that the modem is not on hold. Three-way calling services are also used to free up the shared line for outgoing calls while maintaining the session with holding modems. A table may be employed to screen incoming calls through a comparison of the caller ID information with that in the table. The table may be within the modem or the host computer.

Abstract: A modem to modem communication system supports call waiting services by exchanging hold request and acknowledge signals before relinquishing the line servicing incoming calls. Thereafter, the modem to modem session is reestablished without having to redial. The hold request may be denied or accepted, and may define the duration a modem will hold before hanging up. The holding modem maintains the session by fooling the higher protocol layers, making them believe that the modem is not on hold. Three-way calling services are also used to free up the shared line for outgoing calls while maintaining the session with holding modems. A table may be employed to screen incoming calls through a comparison of the caller ID information with that in the table. The table may be within the modem or the host computer.