Abstract: The present disclosure generally relates to compositions and methods for targeting pro-survival signaling hubs in anoikis-resistant cells, such as anoikis-resistant cancer cells. Embodiments also include methods of changing morphology of cells by inhibiting bleb formation which, in part, reduces survival of the cell and proliferation of the cell by disrupting downstream bleb-driven signaling.

Abstract: A photocurable resin composition, the photocurable resin composition comprises a prepolymer, a first photoinitiator, and a second distinct photoinitiator, the prepolymer comprising a repeating unit, the repeating unit comprising a first functional group and a distinct second functional group, the first photoinitiator having a first absorption wavelength, and the second distinct photoinitiator having a second absorption wavelength, the first photoinitiator having a first absorption wavelength to functionalise the first functional group, and the second distinct photoinitiator having a second absorption wavelength to functionalise the second functional group.

Abstract: A void occlusion device that includes a scaffold defining a plurality of voids and a reinforcement member is described. The scaffold is configured to permit the infiltration of human tissue into the plurality of voids. The reinforcement member extends through at least a portion of the scaffold and is configured to resist compressive forces exerted on the scaffold. Also described are embodiments where the void occlusion device is biocompatible, bioresorbable, elastic, and suitable for radio imaging.

Abstract: A shape memory polymer foam comprising a reaction product of a reaction of an epoxide and a thiol monomer in the presence of an organobase is provided. In addition, a method of making the shape memory polymer foam is provided. The method includes reacting an epoxide with thiol monomers in the presence of an organobase to form the shape memory polymer foam.

Abstract: A shape memory polymer foam comprising a reaction product of a reaction of an epoxide and a thiol monomer in the presence of an organobase is provided. In addition, a method of making the shape memory polymer foam is provided. The method includes reacting an epoxide with thiol monomers in the presence of an organobase to form the shape memory polymer foam.

Abstract: A resin composition, the resin composition including a prepolymer (209) and optionally one or more diluent(s) (FIG. 3A), the prepolymer (209) including repeating units having at least one carbonate linkage and at least one unsaturated side-chain, the at least one optional diluent(s) comprising at least one unsaturated side-chain, with either or both of the prepolymer (209) and the at least one optional diluent(s) including at least one O=C-N linkage, preferably a urethane linkage.

Abstract: A void occlusion device that includes a scaffold defining a plurality of voids and a reinforcement member is described. The scaffold is configured to permit the infiltration of human tissue into the plurality of voids. The reinforcement member extends through at least a portion of the scaffold and is configured to resist compressive forces exerted on the scaffold. Also described are embodiments where the void occlusion device is biocompatible, bioresorbable, elastic, and suitable for radio imaging.

Abstract: A 3D printable resin is provided. The 3D printable resin includes a polystyrene and at least one of a solubilizing crosslinker or a solubilizing polymer. Alternatively, a ring-opened polyester copolymer is provided. The ring-opened polyester copolymer is a product of a reaction between a cyclohexene anhydride and a glycidol allyl ether. In addition, A polyester resin is provided. The polyester resin includes a product of a reaction between a cyclohexene anhydride and a glycidol allyl ether, a 4-arm thiol, and a photoinitiator.

Abstract: A resin composition, the resin composition comprising a prepolymer (209) and optionally one or more diluent(s) (FIG. 3A), the prepolymer (209) comprising repeating units having at least one carbonate linkage and at least one unsaturated side-chain, the at least one optional diluent(s) comprising at least one unsaturated side-chain, wherein either or both of the prepolymer (209) and the at least one optional diluent(s) comprises at least one O?C—N linkage, preferably a urethane linkage.

Abstract: A void occlusion device that includes a scaffold defining a plurality of voids and a reinforcement member is described. The scaffold is configured to permit the infiltration of human tissue into the plurality of voids. The reinforcement member extends through at least a portion of the scaffold and is configured to resist compressive forces exerted on the scaffold. Also described are embodiments where the void occlusion device is biocompatible, bioresorbable, elastic, and suitable for radio imaging.

Abstract: A photocurable resin composition, the photocurable resin composition comprises a prepolymer, a first photoinitiator, and a second distinct photoinitiator, the prepolymer comprising a repeating unit, the repeating unit comprising a first functional group and a distinct second functional group, the first photoinitiator having a first absorption wavelength, and the second distinct photoinitiator having a second absorption wavelength, the first photoinitiator having a first absorption wavelength to functionalise the first functional group, and the second distinct photoinitiator having a second absorption wavelength to functionalise the second functional group.

Abstract: A void occlusion device that includes a scaffold defining a plurality of voids and a reinforcement member is described. The scaffold is configured to permit the infiltration of human tissue into the plurality of voids. The reinforcement member extends through at least a portion of the scaffold and is configured to resist compressive forces exerted on the scaffold. Also described are embodiments where the void occlusion device is biocompatible, bioresorbable, elastic, and suitable for radio imaging.

Abstract: An embodiment includes a system comprising a thermoset polyurethane shape memory polymer (SMP) foam that includes at least one antimicrobial agent. The antimicrobial agent may include at least one phenolic acid that is a pendent group chemically bonded to a polyurethane polymer chain of the SMP foam. Other embodiments are described herein.

Abstract: An embodiment includes a system comprising a thermoset polyurethane shape memory polymer (SMP) foam that includes at least one antimicrobial agent. The antimicrobial agent may include at least one phenolic acid that is a pendent group chemically bonded to a polyurethane polymer chain of the SMP foam. Other embodiments are described herein.

Abstract: A resin composition, the resin composition comprising a prepolymer (209) and optionally one or more diluent(s) (FIG. 3A), the prepolymer (209) comprising repeating units having at least one carbonate linkage and at least one unsaturated side-chain, the at least one optional diluent(s) comprising at least one unsaturated side-chain, wherein either or both of the prepolymer (209) and the at least one optional diluent(s) comprises at least one O?C—N linkage, preferably a urethane linkage.

Abstract: An embodiment includes a system comprising a thermoset polyurethane shape memory polymer (SMP) foam that includes at least one antimicrobial agent. The antimicrobial agent may include at least one phenolic acid that is a pendent group chemically bonded to a polyurethane polymer chain of the SMP foam. Other embodiments are described herein.