Abstract: An arteriovenous graft system including an arteriovenous graft with a valve device. The valve device has an open state in which fluid flow through the graft is possible, and a closed state in which the fluid flow through the arteriovenous graft is blocked. The graft system includes an actuator device to actuate the valve device between the closed state and the open state. A transmission cable connects the actuator device with the valve device. The actuator device includes at least one movable magnet that connects to a rotatable plate which is equipped with a spiralled groove. The spiralled groove receives a pin that is movable in a linear path. The pin is connected to the transmission cable so as to arrange that motion of the magnet translates into a linear displacement of the pin and the transmission cable connected thereto.

Abstract: Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: A method of controlling an idle speed of an engine of a vehicle, includes the steps of determining that the engine is decelerating to or is operating at a nominal idle speed, determining that a vehicle brake is applied, determining an actual or projected electrical load of at least part of a vehicle electrical system is beyond an electrical load threshold, and increasing the engine speed to or maintaining the speed of the engine at a speed greater than the nominal idle speed range as a function of the electrical load to increase the electrical output of a generator coupled to the engine. The method may include determining that the brake is ceasing to be applied and then decreasing the engine speed to or toward the nominal idle speed.

Abstract: Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

Abstract: Aspects described herein generally relate to a sol-gel that is the reaction product of an organosilane, a metal alkoxide, an acid, and a thio-lanthanide salt having a solubility of about 1 gram or greater per gram of sol-gel at 23° C. The thio-lanthanide salt includes a cation and a thio-ligand. The cation can be lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, scandium, yttrium, cobalt, calcium, strontium, barium, and zirconium. In another aspect, a component, such as a vehicle component, includes a metal substrate and a sol-gel disposed on the metal substrate. Methods can include forming a sol-gel by mixing a metal alkoxide and an acid to form a first mixture; mixing with the first mixture an organosilane to form a second mixture; and mixing with the second mixture a lanthanide salt to form a third mixture.

Abstract: A cleaning mechanism of a combine harvester, for cleaning threshed and separated crop material, including a grain pan for receiving threshed and separated crop material and transporting the crop material rearwardly; a chaffer installed proximate the grain pan for receiving material from the grain pan where the chaffer includes a plurality of longitudinal channels with non-planar surfaces giving each channel a curved or trapezoidal cross section and at least two of the chaffer channels have an asymmetric non-planar surface with a greater part of the surface area facing the side portions of the chaffer; and a fan that causes an air flow through the chaffer to lift up discardable parts from the crop material and transport the discardable parts out of the combine harvester.

Abstract: A method of controlling an idle speed of an engine of a vehicle, includes the steps of determining that the engine is decelerating to or is operating at a nominal idle speed, determining that a vehicle brake is applied, determining an actual or projected electrical load of at least part of a vehicle electrical system is beyond an electrical load threshold, and increasing the engine speed to or maintaining the speed of the engine at a speed greater than the nominal idle speed range as a function of the electrical load to increase the electrical output of a generator coupled to the engine. The method may include determining that the brake is ceasing to be applied and then decreasing the engine speed to or toward the nominal idle speed.

Abstract: Disclosed is a machine learning model architecture that leverages existing large language models to analyze log files for security vulnerabilities. In some configurations, log files are processed by an encoder machine learning model to generate embeddings. Embeddings generated by the encoder model are used to construct graphs. The graphs are in turn used to train a graph classifier model for identifying security vulnerabilities. The encoder model may be an existing general-purpose large language model. In some configurations, the nodes of the graphs are the embedding vectors generated by the encoder model while edges represent similarities between nodes. Graphs constructed in this way may be pruned to highlight more meaningful node topologies. The graphs may then be labeled based on a security analysis of the corresponding log files. A graph classifier model trained on the labeled graphs may be used to identify security vulnerabilities.

Abstract: The present disclosure is directed to processes, compositions and agents for inhibiting corrosion in various substrates, for example metal substrates. The present disclosure is also directed to corrosion inhibitors comprising organometallic polymers such as metal-organic frameworks (MOFs), including compositions and processes comprising MOFs for inhibiting corrosion in metal substrates.

Abstract: The present disclosure relates to agents, compositions, and methods for inhibiting corrosion in various substrates, for example in metal substrates. The present disclosure also relates to compositions for inhibiting corrosion comprising at least one organic heterocyclic compound and at least one metal salt or mixed metal salt selected from rare earth, alkali earth and transition metals.

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: The present disclosure is directed to processes, compositions and agents for inhibiting corrosion in various substrates, for example metal substrates. The present disclosure is also directed to corrosion inhibitors comprising organometallic polymers such as metal-organic frameworks (MOFs), including compositions and processes comprising MOFs for inhibiting corrosion in metal substrates.

Abstract: The present disclosure relates to agents, compositions, and methods for inhibiting corrosion in various substrates, for example in metal substrates. The present disclosure also relates to compositions for inhibiting corrosion comprising at least one organic heterocyclic compound and at least one metal salt or mixed metal salt selected from rare earth, alkali earth and transition metals.

Abstract: A method performed by a session initiation system (SIS) for reducing a time to authenticate a user includes communicating, to a mobile device, session identifying information associated with a session. The mobile device is configured to subsequently communicate at least part of the session identifying information to an authentication server, and the authentication server is configured to subsequently communicate account information associated with the session identifying information to an intermediate gateway.

Abstract: A drip filter coffee making device has a filter basket with a lid. The lid supports a water dispenser for wetting grounds in the filter basket. The basket is removable from a body of the device. The lid may have a dampened opening motion, biased into an open position by a spring.

Abstract: Aspects described herein generally relate to a sol-gel that is the reaction product of an organosilane, a metal alkoxide, an acid, and a thio-lanthanide salt having a solubility of about 1 gram or greater per gram of sol-gel at 23° C. The thio-lanthanide salt includes a cation and a thio-ligand. The cation can be lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, scandium, yttrium, cobalt, calcium, strontium, barium, and zirconium. In another aspect, a component, such as a vehicle component, includes a metal substrate and a sol-gel disposed on the metal substrate. Methods can include forming a sol-gel by mixing a metal alkoxide and an acid to form a first mixture; mixing with the first mixture an organosilane to form a second mixture; and mixing with the second mixture a lanthanide salt to form a third mixture.

Abstract: There are described novel compounds of formula I: (I) in which, in which A1, A2, A3, A4, R1 and R2 are each as herein defined, for use in the treatment or alleviation of an RAR mediated condition; and methods related thereto.