Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: A reheat assembly for a gas turbine engine includes; a jetpipe casing defining a reheat core section configured to duct a core flow of air and a reheat bypass section configured to duct a bypass flow of air. The reheat bypass section is disposed radially outward of the reheat core section, and the reheat core section and the reheat bypass section are at least partially separated by a support duct. An integrated flameholder is mounted to the jetpipe casing, and a fuel pipe is configured to convey fuel to the integrated flameholder. The integrated flameholder includes a flameholder body extending radially inward from the jetpipe casing through the reheat bypass section and into the reheat core section to promote a wake-stabilised region downstream of the body; and an integrated atomiser configured to atomise fuel provided to the integrated flameholder and to discharge the atomised fuel into the wake stabilised region.

Abstract: This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: A reheat assembly for gas turbine engine including a jetpipe casing having a reheat core section configured to flow air from inlet to outlet; and reheat bypass section configured to bypass air from inlet to outlet, wherein the reheat core section and the reheat bypass section are radially separated by support duct within the jetpipe casing; reheat arrangement including a radially extending flameholder and a core fuel injection port, wherein: the flameholder, mounted to the jetpipe casing, extends through the reheat bypass section and partly into the reheat core section; the flameholder is configured to form a wake-stabilised region within the core flow of air and the bypass flow of air downstream of the flameholder; and the core fuel injection port is: circumferentially aligned with the flameholder upstream of the wake-stabilised region, and configured to discharge fuel into the reheat core section for mixing with the core flow of air.

Abstract: A reheat assembly for a gas turbine engine includes; a jetpipe casing defining a reheat core section configured to duct a core flow of air and a reheat bypass section configured to duct a bypass flow of air. The reheat bypass section is disposed radially outward of the reheat core section, and the reheat core section and the reheat bypass section are at least partially separated by a support duct. An integrated flameholder is mounted to the jetpipe casing, and a fuel pipe is configured to convey fuel to the integrated flameholder. The integrated flameholder includes a flameholder body extending radially inward from the jetpipe casing through the reheat bypass section and into the reheat core section to promote a wake-stabilised region downstream of the body; and an integrated atomiser configured to atomise fuel provided to the integrated flameholder and to discharge the atomised fuel into the wake stabilised region.

Abstract: A reheat assembly for a gas turbine engine includes: a jetpipe casing including: a reheat core section configured to convey a core flow of air from a reheat core inlet to a reheat core outlet; and a reheat bypass section configured to convey a bypass flow of air from a reheat bypass inlet to a reheat bypass outlet radially outward of the reheat core section, wherein the reheat core and reheat bypass sections are radially separated at the reheat core and reheat bypass inlets by a support duct within the jetpipe casing; a reheat arrangement including a radially extending flameholder and a plurality of fuel injection ports including a plurality of core fuel injection ports, wherein: the flameholder is configured to promote a formation of a core flow wake-stabilised region within the core flow of air downstream of the flameholder; and each of the plurality of core fuel injection ports are: circumferentially aligned with the flameholder upstream of the core flow wake-stabilised region, configured to discharge a re

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: The present invention relates to a method for analyzing DNA including forming labeled DNA fragments by cleaving genomic DNA into DNA fragments, selectively functionalizing any non-methylated CpG sites present in the DNA with a linker including a hydrolyzable moiety, and attaching a label to the linker. The method further includes the step of separating the labeled DNA fragments from any non-labeled DNA fragments, hydrolyzing the hydrolyzable moiety of the linker of the separated labeled DNA fragments so as to release the DNA fragments from the label, and sequencing the released DNA fragments.

Abstract: A method of reversibly labeling a biomolecule including providing a linker molecule (11) having a first functional group (LG) with a reactive center, a second functional group (FG) with a reactive center, and a cleavable, e.g. hydrolyzable, moiety (A-B-C). The method further includes forming a covalent bond between the biomolecule (10) and the reactive center of the first functional group (LG), forming a covalent bond between a first label (L1) and the reactive center of the second functional group (FG), cleaving the cleavable moiety (A-B-C), e.g. hydrolyzing the hydrolyzable moiety, of the linker molecule (11) to remove the first label (L1) and to form a third functional group (W) with a reactive center, and forming a covalent bond between a further molecule and the reactive center of the third functional group (W) to reform the cleavable moiety, e.g. hydrolyzable moiety (A-B-C).

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.

Abstract: A rotor for an electrical machine includes a rotor core having a plurality of circumferentially spaced apart rotor poles. A plurality of windings are seated in gaps between circumferentially adjacent pairs of the rotor poles. A respective wedge secures the windings in each gap configured to supply Q-axis damping. A pair of end plates are connected electrically to the wedges at opposing longitudinal ends thereof thereby completing a Q-axis winding circuit for each wedge.

Abstract: The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: An LED light fixture having an inexpensive camera or sensor is disclosed. The LED light fixture utilizes a controller that is configured to turn the LED light on and/or adjust brightness of the LED in response to motion only within a perimeter programmed into the controller. This perimeter can be defined by known light output of known LED lenses. The ability to program light detection to be only within a given perimeter allows for the use of generic sensors, such as fisheye cameras, with varying lenses and LED bulbs to provide a lower cost option in motion sensing technology.

Abstract: The present invention relates to a compound that is useful as an inhibitor of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising this compound and to methods of using this compound in the treatment of cancer and methods of treating cancer.

Abstract: An LED array having a driver connected to a sensor. The sensor can be either integral with a controller or separate from the driver and in communication with the controller. The sensor is configured to sense one or more of the temperature, forward voltage, LED voltage, and/or total driver power. The controller is preferably configured for wireless connectivity with a local computer, such as by Bluetooth® or configured for an internet connection to allow for remote monitoring of the LED array. The controller can be configured to compare the sensed voltage, temperature, forward voltage, and/or driver power and compare it to a programmed and/or sensed base and notify of a fault. Alternatively, the controller can be connected to a computer via internet and/or wireless signal (such as Bluetooth®) to compare the sensed condition to a normal condition to determine if a fault has occurred.

Abstract: A method of ordering multiple resources in a transaction includes receiving a transaction for a plurality of resources and determining, for each resource, the work embodied by the transaction. The work includes at least one identified parameter relating to an operation for the resource. The method further may include specifying an order of the resources according to the determination of the work, committing the transaction, and invoking the resources in the selected order. Specifying the order of the resources may include specifying the resource to be invoked last. Alternatively, or additionally, specifying the order of the resources also may include specifying that each resource carrying out read-only work be invoked first.

Abstract: A rotor for an electrical machine includes a rotor core having a plurality of circumferentially spaced apart rotor poles. A plurality of windings are seated in gaps between circumferentially adjacent pairs of the rotor poles. A respective wedge secures the windings in each gap configured to supply Q-axis damping. A pair of end plates are connected electrically to the wedges at opposing longitudinal ends thereof thereby completing a Q-axis winding circuit for each wedge.