Abstract: Apparatus (10) for use in martial arts or fitness training, comprises a strike surface adapted to be kicked or punched by a user during training, and mounting means (12) adapted for removably securing the strike surface (11) to a structural element, such as a door frame. The mounting means (12) are shaped and dimensioned so as to receive the structural element, and comprise at least one inflatable bladder (16) adapted upon inflation to cause the mounting means (12) to grip the structural element.

Abstract: According to a first aspect of the present invention there is provided an oral fluid collection device. The oral fluid collection device comprises a handle, a swab holder, and a swab. The swab is in the form of a hollow tube of absorbent material coaxially located about the swab holder, such that the swab is supported by the swab holder along the entire length of the swab.

Abstract: Apparatus (10) for use in martial arts or fitness training, comprises a strike surface adapted to be kicked or punched by a user during training, and mounting means (12) adapted for removably securing the strike surface (11) to a structural element, such as a door frame. The mounting means (12) are shaped and dimensioned so as to receive the structural element, and comprise at least one inflatable bladder (16) adapted upon inflation to cause the mounting means (12) to grip the structural element.

Abstract: Protective apparel for use in martial arts or fitness training exercises involving contact between two participants, such as pad work or spar training, comprises a strike surface (11) carried on an inflatable bladder (12), and securing means (21-23) to enable the apparel (10, 40) to be worn by a user (30) during spar training. During use, the inflatable bladder (12) is inflated to a sufficient pressure to withstand strikes from a sparring partner. The protective apparel may take the form of a torso protector (10) or thigh protector (40), or other variants. These may be worn by the user (30) either alone or in combination to increase the area of the strike surface (11), and thus also increase the area of the user's body (30) which is protected.

Abstract: According to a first aspect of the present invention there is provided an oral fluid collection device 1. The oral fluid collection device 1 comprises a handle 2, a swab holder 4, and a swab 3. The swab 3 is in the form of a hollow tube of absorbent material coaxially located about the swab holder 4, such that the swab 3 is supported by the swab holder 4 along the entire length of the swab 3.

Abstract: Compounds having the formula (I): and in particular, those of subgenus VIIa are disclosed as inhibits or modulators of the activity of the heat shock protein Hsp90. As such they are useful for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma.

Abstract: The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

Abstract: The invention provides compounds of the formula (1): The compounds have activity against cyclin depdenent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.

Abstract: The invention provides compounds of the formula (I): The compounds have activity against cyclin dependent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.

Abstract: The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g.

Abstract: Compounds of the formula (I), wherein: —X?Y— is selected from —CR<2>=CR<3>— and —CR<2>?N—; R<1> is selected from H, halo, NRR?, NHC(?O)R, NHC(?O)NRR?, NH2SO2R, and C(?O)NRR?; R<2> and R<3> (where present) are independently selected from H, optionally substituted C1-7 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, halo, amino, amido, hydroxy, ether, thio, thioether, acylamido, ureido and sulfonamino; R<4> is an optionally substituted C5-20 aryl or C5-20 heteroaryl group; and R<5> is selected from R<5?>, halo, NHR<5?>, C(?O)NHR<5?>, OR<5?>, SR<5?>, NHC(?O)R<5?>, NHC(?O)NHR<5?>, NHS(?O)R<5?>, wherein R<5?> is H or C1-3 alkyl (optionally substituted by halo, NH2, OH, SH) are disclosed for use in therapy and for treating diseases ameliorated by inhibiting p38 MAP kinase.