Patents by Inventor Andrew Wu

Andrew Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10472347
    Abstract: Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein “R1”, “RA-1”, “R2”, “R3”, and “Het” are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: November 12, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Rongze Kuang, Pauline Ting, Amjad Ali, Heping Wu, Michael Berlin, Andrew Stamford, Hongwu Wang, Gang Zhou, David Kim, Qiaolin Deng, Yeon-Hee Lim, Younong Yu
  • Publication number: 20190338353
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.
    Type: Application
    Filed: May 30, 2019
    Publication date: November 7, 2019
    Inventors: Phillip Belgrader, Zachary Bent, Rajiv Bharadwaj, Vijay Kumar Sreenivasa Gopalan, Josephine Harada, Christopher Hindson, Mohammad Rahimi Lenji, Michael Ybarra Lucero, Geoffrey McDermott, Elliott Meer, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Serge Saxonov, John R. Stuelpnagel, Jessica Michele Terry, Tobias Daniel Wheeler, Indira Wu, Solongo Batjargal Ziraldo
  • Patent number: 10467633
    Abstract: A business software application system and method are provided that include a feed system for distributing changes about the application/module to a group of users and a cloud connector system that links external data sources to the business software application system and method.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: November 5, 2019
    Assignee: SUGARCRM INC.
    Inventors: Yun-Ping Hsu, Majed Itani, Ajay Gupta, Roger Smith, Rob Aagaard, Andrew Wu, Collin Lee, Lila Alexei Tretikov
  • Publication number: 20190328761
    Abstract: The present invention relates to methods of increasing vascular density and/or blood flow in tissue of a subject, and to increasing exercise capacity of a subject, the methods include administering to a subject an effective amount of an agent that elevates SIRT1 activity in endothelial cells of the subject, the invention further includes administering an NAD+ agonist or NAD+ precursor to a subject to increase vascular density and/or blood flow. The invention includes compositions comprising the said agent.
    Type: Application
    Filed: December 21, 2017
    Publication date: October 31, 2019
    Inventors: Lindsay Edward Wu, David Andrew Sinclair, Abhirup Das
  • Patent number: 10451478
    Abstract: A device for detecting exposure to light includes: a photo-responsive layer including a photochromic material; a skin-mimicking cover layer covering a first side of the photo-responsive layer; and an adhesive layer configured to couple a second side of the photo-responsive layer opposite the first side to a surface.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: October 22, 2019
    Assignee: 8996598 CANADA INC.
    Inventors: Chad Mitchell Sweeting, Derek Matti Harry Jouppi, Andrew Bradley Martinko, Marc William Gibson, Tim Wu, Kevin Quang Vinh Dang, Cameron Spencer Mills, Sabrina Chwen-Huei Chang
  • Patent number: 10452783
    Abstract: A method, system, and computer program product provide a conversation agent to process natural language queries expressed by a user and perform commands according to the derived intention of the user. A natural language processing (NLP) engine derives intent using conditional random fields to identify a domain and at least one task embodied in the query. The NLP may further identify one or more subdomains, and one or more entities related to the identified command. A template system creates a data structure for information relevant to the derived intent and passes a template to a services manager for interfacing with one or more services capable of accomplishing the task. A dialog manager may elicit more entities from the user if required by the services manager and otherwise engage in conversation with the user. In one embodiment, the conversational agent allows a user to engage in multiple conversations simultaneously.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: October 22, 2019
    Assignee: Maluuba, Inc.
    Inventors: Sam Pasupalak, Joshua R. Pantony, Wilson Hsu, Zhiyuan Wu, Phil Tregenza, Kaheer Suleman, James Simpson, Andrew McNamara, Tareq Ismail
  • Patent number: 10441356
    Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: October 15, 2019
    Assignee: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.
    Inventors: Denise Zarins, Andrew Wu, Hanson Gifford, III, Mark Deem, Mark Gelfand, Howard R. Levin
  • Patent number: 10429256
    Abstract: Nanoscale stress-sensing can be used across fields ranging from detection of incipient cracks in structural mechanics to monitoring forces in biological tissues. We demonstrate how tetrapod quantum dots (tQDs) embedded in block-copolymers act as sensors of tensile/compressive stress. Remarkably, tQDs can detect their own composite dispersion and mechanical properties, with a switch in optomechanical response when tQDs are in direct contact. Using experimental characterizations, atomistic simulations and finite-element analyses, we show that under tensile stress, densely-packed tQDs exhibit a photoluminescence peak shifted to higher energies (“blue-shift”) due to volumetric compressive stress in their core; loosely-packed tQDs exhibit a peak shifted to lower energies (“red-shift”) from tensile stress in the core. The stress-shifts result from the tQD's unique branched morphology in which the CdS arms act as antennas that amplify the stress in the CdSe core.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: October 1, 2019
    Assignee: The Regents of the University of California
    Inventors: Shilpa N. Raja, Danylo Zherebetskyy, Siva Wu, Peter Ercius, Andrew C. K. Olson, Paul Alvisatos, Robert O. Ritchie, Sanjay Govindjee
  • Patent number: 10428072
    Abstract: The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition thereof, and their use for the treatment of pain, inflammatory disease, neuropathy, dermatological disorders, pulmonary conditions, and cough, as well as inhibiting the Transient Receptor Potential A1 ion channel (TRPA1).
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 1, 2019
    Assignee: Eli Lilly and Company
    Inventors: Blaise S. Lippa, Xinyuan Wu, Qingyi Li, Iwona Wrona, Andrew J. Jackson, Bertrand L. Chenard, Christopher M. Liu, Guohua Liang, Matthew F. Baevsky, Richard A. Earl, Lisa Mcqueen, Jared Smit, Brett A. Cowans
  • Patent number: 10430293
    Abstract: In one example, a method for backing up data includes downloading configuration information that includes one or more policies that specify one or more aspects of a backup process. Next, a notification is received concerning a “start” command, receipt of the notification is acknowledged, and the “start” command is performed to create a backup job in a job queue. A signal is then sent indicating that the “start” command is finished, and a backup start event is created. The backup process is then performed, and a report generated indicating that success or failure of the backup process.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: October 1, 2019
    Assignee: EMC IP HOLDING COMPANY LLC
    Inventors: Andrew Skowronski, Joseph Cline, Jian Li, Russell Budd Simons, Zhaoding Wu
  • Publication number: 20190292825
    Abstract: A hinge assembly that includes a frame adapter having a curved inner surface with a front portion and a rear portion, a door adapter having a curved outer surface with a front portion and a rear portion, at least one front hinge strip that is secured along a front hinge strip path, and at least one rear hinge strip that is secured along a rear hinge strip path. The front hinge strip path extends from the front portion of the curved outer surface of the door adapter to the rear portion of the curved inner surface of the frame adapter. The rear hinge strip path extends from the rear portion of the curved outer surface of the door adapter to the front portion of the curved inner surface of the frame adapter. The curved outer surface of the door adapter opposes the curved inner surface of the frame adapter and the door adapter is movable relative to the frame adapter between a front open position, a closed position and a rear open position.
    Type: Application
    Filed: March 19, 2019
    Publication date: September 26, 2019
    Inventors: Tyler Smithson, Songlin Wu, Jordan Ellsworth, Derrek Lewis, Andrew Wade, Darmo Tandjung
  • Publication number: 20190291843
    Abstract: A saloon-type door assembly that includes left and right door assemblies that each include a frame adapter having a curved inner surface with a first apex, a front portion and a rear portion, a door adapter that includes a curved outer surface with a second apex a front portion and a rear portion, a door panel associated with the door adapter, at least one front hinge strip secured along a front hinge strip path, and at least one rear hinge strip that is secured along a rear hinge strip path. The front hinge strip path extends from the front portion of the curved outer surface of the door adapter to the rear portion of the curved inner surface of the frame adapter. The rear hinge strip path extends from the rear portion of the curved outer surface of the door adapter to the front portion of the curved inner surface of the frame adapter. The door panels are movable between a front open position, a closed position and a rear open position.
    Type: Application
    Filed: March 19, 2019
    Publication date: September 26, 2019
    Inventors: Tyler Smithson, Songlin Wu, Jordan Ellsworth, Dustin Bonkemeyer, Derrek Lewis, Andrew Wade, Tyler Peacock, Darmo Tandjung
  • Patent number: 10424219
    Abstract: Provided are systems and methods using which users may learn and become familiar with the effects of various aspects of their lifestyle on their health, e.g., users may learn about how food and/or exercise affects their glucose level and other physiological parameters, as well as overall health. In some cases the user selects a program to try; in other cases, a computing environment embodying the system suggests programs to try, including on the basis of pattern recognition, i.e., by the computing environment determining how a user could improve a detected pattern in some way. In this way, users such as type II diabetics or even users who are only prediabetic or non-diabetic may learn healthy habits to benefit their health.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: September 24, 2019
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Robert J. Boock, David DeRenzy, Laura J. Dunn, Matthew Lawrence Johnson, Katherine Yerre Koehler, Apurv Ullas Kamath, Andrew Attila Pal, David Price, Eli Reihman, Mark Wu
  • Patent number: 10420606
    Abstract: Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: September 24, 2019
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Denise Zarins, Hanson Gifford, III, Mark Deem, Nicolas Zadno, Benjamin J. Clark, Andrew Wu, Kenneth J. Michlitsch
  • Patent number: 10416845
    Abstract: Systems and methods for presenting content that depicts one or more stories are provided. Content that depicts one or more stories is received from a first client device. The content that depicts the one or more stories is grouped into an edition being used to represent the one or more stories. A discovery page that enables selection of the edition is generated. Presentation of the discovery page is caused on a second client device.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: September 17, 2019
    Assignee: Snap Inc.
    Inventors: Nicholas Richard Allen, Nicholas James Bell, Andrew Cooper, Chamal Samaranayake, William Wu
  • Patent number: 10410538
    Abstract: Provided are systems and methods using which users may learn and become familiar with the effects of various aspects of their lifestyle on their health, e.g., users may learn about how food and/or exercise affects their glucose level and other physiological parameters, as well as overall health. In some cases the user selects a program to try; in other cases, a computing environment embodying the system suggests programs to try, including on the basis of pattern recognition, i.e., by the computing environment determining how a user could improve a detected pattern in some way. In this way, users such as type II diabetics or even users who are only prediabetic or non-diabetic may learn healthy habits to benefit their health.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: September 10, 2019
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Robert J. Boock, David DeRenzy, Laura J. Dunn, Matthew Lawrence Johnson, Katherine Yerre Koehler, Apurv Ullas Kamath, Andrew Attila Pal, David Price, Eli Reihman, Mark Wu
  • Publication number: 20190269695
    Abstract: Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.
    Type: Application
    Filed: August 1, 2017
    Publication date: September 5, 2019
    Inventors: Shunlin Ren, Leyuan Xu, Yanxia Ning, Jin Koung Kim, WeiQi Lin, Mee Jean Kim, Andrew R. Miksztal, Hongwei Wu, Min L. Lee, Wilma Tamraz
  • Publication number: 20190269908
    Abstract: Catheter assemblies for neuromodulation proximate a renal artery bifurcation and associated systems and methods are disclosed herein. A catheter assembly configured in accordance with a particular embodiment of the present technology can include a shaft having a proximal portion, a distal portion, and two therapeutic arms extending from the distal portion. The shaft can be configured to deliver the distal portion to a treatment site proximate a branch point or bifurcation in a renal blood vessel. The therapeutic arms can include energy delivery elements that are configured to deliver the therapeutically-effective energy to renal nerves proximate the branch point.
    Type: Application
    Filed: March 4, 2019
    Publication date: September 5, 2019
    Inventors: Neil C. Barman, Robert J. Beetel, Benjamin J. Clark, Andrew Wu, Maria G. Aboytes, Denise Zarins
  • Patent number: 10385048
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: August 20, 2019
    Assignee: SYNGENTA PARTICIPATION AG
    Inventors: Andrew Edmunds, Pierre Joseph Marcel Jung, Michel Muehlebach, Long Lu, Yaming Wu, Ruifang Chen
  • Publication number: 20190248903
    Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: January 17, 2019
    Publication date: August 15, 2019
    Applicant: Genentech, Inc.
    Inventors: Bing ZHENG, Andrew Polson, Cecilia Chiu, Wei-Ching Liang, Yan Wu