Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.

Abstract: A regulator with a high side pass device and a low side pass device coupled in series to the high side pass device is disclosed. The apparatus further includes a control module coupled to the high side pass device and the low side pass device. The control module is coupled to the high side pass device and the low side pass device to control the high side pass device and the low side pass device. The control module is operable to lock out the high side pass device under certain conditions.

Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: Multi-directional deflectable catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: In one embodiment, a method is provided for a power converter system. The method includes: providing a primary current limit for the power converter system, wherein the power converter system has one or more transistors which can be switched on at a primary frequency to cause current to flow through an inductor of the power converter system; and using the primary current limit for over-current protection in the power converter system, wherein over-current protection does not employ any secondary frequency for switching of the one or more transistors and does not employ any secondary current limit.

Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

Abstract: The present disclosure describes methods and apparatus for renal neuromodulation via stereotactic radiotherapy for the treatment of hypertension, heart failure, chronic kidney disease, diabetes, insulin resistance, metabolic disorder or other ailments. Renal neuromodulation may be achieved by locating renal nerves and then utilizing stereotactic radiotherapy to expose the renal nerves to a radiation dose sufficient to reduce neural activity. A neural location element may be provided for locating target renal nerves, and a stereotactic radiotherapy system may be provided for exposing the located renal nerves to a radiation dose sufficient to reduce the neural activity, with reduced or minimized radiation exposure in adjacent tissue. Renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as at pre-ganglionic positions.

Abstract: A regulator with a high side pass device and a low side pass device coupled in series to the high side pass device is disclosed. The apparatus further includes a control module coupled to the high side pass device and the low side pass device. The control module is coupled to the high side pass device and the low side pass device to control the high side pass device and the low side pass device. The control module is operable to lock out the high side pass device under certain conditions.

Abstract: Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: A regulator with a high side pass device and a low side pass device coupled in series to the high side pass device is disclosed. The apparatus further includes a control module coupled to the high side pass device and the low side pass device. The control module is coupled to the high side pass device and the low side pass device to control the high side pass device and the low side pass device. The control module is operable to lock out the high side pass device under certain conditions.

Abstract: A switch-mode DC/DC converter and a linear low drop out (LDO) DC/DC regulator are connected in parallel to drive a single load. Both regulators share a common voltage reference, feedback network, input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator disabled, also maximizing the efficiency. Each regulator senses load current to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators to minimize the voltage transients.

Abstract: An echo canceller comprising a first adaptive filter having N_long coefficients for converging to an echo path, a non-adaptive filter representing a direct echo path portion captured by the first adaptive filter and having N_short default coefficients, where N_long>N_short, for quick convergence of the echo canceller at start-up, wherein the default coefficients are replaced by the first N_short coefficients from the first adaptive filter responsive to an improvement in echo return loss enhancement (ERLE) of the first adaptive filter, a second adaptive filter having N_short default coefficients for modeling the direct echo path and providing an indication of double-talk and echo path changes, decision logic for receiving error signal outputs from the first and second adaptive filters and the non-adaptive filter and in response distinguishing between echo path changes and double-talk, and a non-linear processor for attenuating signals responsive to input from the decision logic.

Abstract: The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.

Abstract: A switch-mode DC/DC converter and a linear low drop out (LDO) DC/DC regulator are connected in parallel to drive a single load. Both regulators share a common voltage reference, feedback network, input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator disabled, also maximizing the efficiency. Each regulator senses load current to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators to minimize the voltage transients.

Abstract: A regulator with a high side pass device and a low side pass device coupled in series to the high side pass device is disclosed. The apparatus further includes a control module coupled to the high side pass device and the low side pass device. The control module is coupled to the high side pass device and the low side pass device to control the high side pass device and the low side pass device. The control module is operable to lock out the high side pass device under certain conditions.

Abstract: A business software application system and method are provided that include a feed system for distributing changes about the application/module to a group of users and a cloud connector system that links external data sources to the business software application system and method.

Abstract: Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: A regulator with a high side pass device and a low side pass device coupled in series to the high side pass device is disclosed. The apparatus further includes a control module coupled to the high side pass device and the low side pass device. The control module is coupled to the high side pass device and the low side pass device to control the high side pass device and the low side pass device. The control module is operable to lock out the high side pass device under certain conditions.

Abstract: Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.