Abstract: The present disclosure relates to use of a protein kinase C (PKC) inhibitor in the treatment or prevention of proliferative diseases. The disclosure also relates to corresponding pharmaceutical formulations, uses, methods, combinations, and related disclosure embodiments. The disclosure further relates to use of a pharmaceutical combination comprising a PKC inhibitor and another therapeutic agent, such as an MDM2 inhibitor, in the treatment or prevention of a proliferative disease.

Abstract: The present disclosure relates to use of a protein kinase C (PKC) inhibitor in the treatment or prevention of proliferative diseases. The disclosure also relates to corresponding pharmaceutical formulations, uses, methods, combinations, and related disclosure embodiments. The disclosure further relates to use of a pharmaceutical combination comprising a PKC inhibitor and another therapeutic agent, such as an MDM2 inhibitor, in the treatment or prevention of a proliferative disease.

Abstract: The present disclosure relates to use of a protein kinase C (PKC) inhibitor in the treatment or prevention of proliferative diseases. The disclosure also relates to corresponding pharmaceutical formulations, uses, methods, combinations, and related disclosure embodiments. The disclosure further relates to use of a pharmaceutical combination comprising a PKC inhibitor and another therapeutic agent, such as an MDM2 inhibitor, in the treatment or prevention of a proliferative disease.

Abstract: The exit area of a nozzle assembly is varied by translating a ring assembly located at a rear of the engine nacelle. The ring may be axially translatable along the axis of the engine. As the ring translates, the trailing edge of the ring defines a variable nozzle exit area. Translation of the ring creates an upstream exit at a leading edge of the ring assembly. The upstream exit can be used to bleed or otherwise spill flow excess from the engine bypass duct. As the engine operates in various flight conditions, the ring can be translated to obtain lower fan pressure ratios and thereby increase the efficiency of the engine. Fairings partially enclose actuator components for reduced drag.

Abstract: A method of digital sampling of a current or group of currents in an electrical system including using in the sampling, sufficient bandwidth to reconstruct the amplitude and phase of a synthesized power frequency and its harmonics and a fundamental carrier frequency of switching electronics and modulation sidebands.

Abstract: An actuator arrangement comprises an actuator having a rotatable drive input, a motor, and a drive transmission arrangement for transmitting rotary drive from the motor to the rotatable drive input of the actuator, wherein the transmission arrangement includes a telescopic drive coupling.

Abstract: A method of digital sampling of a current or group of currents in an electrical system including using in the sampling, sufficient bandwidth to reconstruct the amplitude and phase of a synthesized power frequency and its harmonics and a fundamental carrier frequency of switching electronics and modulation sidebands.

Abstract: The exit area of a nozzle assembly is varied by translating a ring assembly located at a rear of the engine nacelle. The ring may be axially translatable along the axis of the engine. As the ring translates, the trailing edge of the ring defines a variable nozzle exit area. Translation of the ring creates an upstream exit at a leading edge of the ring assembly. The upstream exit can be used to bleed or otherwise spill flow excess from the engine bypass duct. As the engine operates in various flight conditions, the ring can be translated to obtain lower fan pressure ratios and thereby increase the efficiency of the engine. Fairings partially enclose actuator components for reduced drag.

Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: An actuator arrangement comprises an actuator having a rotatable drive input, a motor, and a drive transmission arrangement for transmitting rotary drive from the motor to the rotatable drive input of the actuator, wherein the transmission arrangement includes a telescopic drive coupling.

Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract: A hydraulic drive system incorporating a hydraulic pump for three wheeled vehicles such as “piggy back” forklifts in which there are at least two separate but linked drives forming one drive unit for each of the wheels and each drive has a separate input and output. Valving is provided to provide both parallel and series operation of the system for optimum torque, speed and anti skid operation. In one preferred way of carrying out the invention a single drive unit feeds one of the drives of each of the other drives. The hydraulic pump feeds the single drive unit and one of the drives of the other transverse drive units. By-pass diverter valves are fitted across the drives of the transverse drive units.

Abstract: A crash bar assembly for a vehicle having an auxiliary equipment carrying mode with, for example, a forklift extending beyond its rearmost portion. The impact absorbing bar forming part of the assembly is movable outwardly to adjacent the rearmost end of the forklift on bars in sockets. A forklift may have a crash bar assembly mounted on itself.

Abstract: A universal forklift truck mounting frame (1) for fitting at a rear end of a carrier vehicle chassis has a composite base support framework. The base support framework has a rear support beam (8) and a front support beam (20) interconnected by a pair of spaced-apart hanger plates (5). Each hanger plate (5) has a flanged upper end (6) to provide a laterally extending chassis engaging surface. A wheel rest plate (9) is mounted at each end of the rear support beam (8). A pair of fork support sleeves (18), each for engagement with a fork of a forklift truck are mounted on the support framework between and substantially parallel to the hanger plates (5). A crash bar (10) is mounted at a rear end of the hanger plates (5).