Abstract: The present disclosure relates to a plurality of granules comprising N-(2-(tert-butyl)-1-((4,4-difluorocyclohexyl)methyl)-1H-benzimidazol-5-yl)ethanesulfonamide, or a pharmaceutically acceptable salt thereof, as an active substance. The plurality of granules are suitable for use in pharmaceutical compositions. The pharmaceutical compositions are suitable for use in the treatment of medical conditions in which treatment with agonists of CB1/CB2 receptors are beneficial.

Abstract: The present disclosure relates to pharmaceutical compositions comprising Compound I, or a pharmaceutically acceptable salt thereof, as the active substance. The pharmaceutical compositions are suitable for use in immediate release pharmaceutical formulations. The pharmaceutical formulations are suitable for use in the treatment of medical conditions in which treatment with agonists of CB1/CB2 receptors are beneficial.

Abstract: Apparatus for manual haptic stimulation of the male sex organ of an individual may include a penis pump assembly and a traveling carrier assembly. The apparatus also may include a stroker sleeve carried by the travelling carrier assembly. The traveling carrier assembly may include an internal carrier inside a vacuum chamber, an external carrier outside the vacuum chamber, and a carrier interconnection assembly joining the internal carrier in interconnected relationship relative to the external carrier by a plurality of paired magnetic rollers for movement in common of the internal carrier and external carrier upon movement of the external carrier when the vacuum chamber is configured in the reduced pressure condition.

Abstract: The present invention relates to methods for producing a particle comprising a polymer matrix and a protein.

Abstract: The invention provides a method of operating a diesel engine under oxygen-limited conditions such that the efficiency of the engine is at least 1% improved over the engine efficiency obtained when using a conventional crude-derived diesel fuel, said method including the combustion of a distillate fuel having a density of below 0.800 g.cm?3 in the engine. The invention extends to the use of a distillate fuel with a density less than 0.800 g.cm?3 (at 20° C.) for achieving increased engine efficiency when operating a diesel engine under oxygen-limited conditions, said use including combusting said fuel such that the efficiency of the engine is at least 1% improved over the engine efficiency obtained when using a conventional crude-derived diesel fuel.