Abstract: Provided herein are methods of making and using reprogrammed neuronal cells and neuronal spheroids from patient-derived somatic cells in 3D-cultures, by expressing at least one neurogenic miRNA and optionally at least one neurogenic transcription factor.

Abstract: An ankle brace configured to be worn by a target wearer having a foot, an ankle, a lower leg, and a tibia and a fibula disposed within the lower leg, is disclosed. The ankle brace comprises a foot plate having a foot bed contoured to underlie the foot. The foot bed has a heel cup extending upward from the foot bed and has a relatively greater flexibility than a front foot portion of the foot bed. An orthopedic splint is pivotably coupled to the foot plate and configured to at least partially wrap around the lower leg. The orthopedic splint is disposed in an adjustable pocket, which is configured to adjust compression of the orthopedic splint relative to the lower leg to promote a rehabilitative position of the tibia and the fibula. The foot plate may be fabricated with a computer aided manufacturing process.

Abstract: Among the various aspects of the present disclosure is the provision of cells that mirror, recapitulate, mimick, or substantially express endogenous tau isoforms and methods of making and using same.

Abstract: Systems and methods for distribution, storage, transport, administration and/or disposal of one or more therapeutic or diagnostic agents are disclosed. A storage device configured to connect to a delivery system for delivering the therapeutic or diagnostic agent has a housing with a chamber, a vessel having an access port positioned within the chamber. The door is movable relative to the housing between a closed position and an open position. In the closed position, the door covers an opening in the housing to enclose the chamber, and, in the open position, the door reveals the opening for accessing the access port of the vessel. The door is moveable between the closed position and the open position in response to actuation by an access mechanism of the delivery system.

Abstract: A center console assembly includes a frame, and upper member and a tray insert. The frame has a first side wall, a second side wall and an upper section attached to the first and second side walls with a cavity defined between the first side wall and the second side wall. The cavity is dimensioned to cover and conceal a battery therein. The upper member is installed to the frame and has an opening that exposes a battery. The upper member is dimensioned and shaped to attach to an upper end of the frame. The tray insert is dimensioned to removably attach to the upper member such that with the tray insert removed from the upper member, a ground connection area of the battery is exposed and with the tray insert installed to the upper member, the battery is concealed by the tray insert.

Abstract: The present invention relates to compositions and methods for modulating miRNAs acitivity in a population of cells or a subject. More particularly, the invention relates to inhibiting the expression and/or activity of miR-29b-3p to enhance neuronal survival during neurodegeneration.

Abstract: Bowel retractor devices. In various forms, the bowel retractor devices are configurable from a collapsed position wherein the retractor may be inserted through a trocar cannula or other opening in a patient's body to a second expanded position wherein at least a portion of the patient's bowel may be advantageously supported in a desired position.

Abstract: Among the various aspects of the present disclosure is the provision of a method of generating a neuron. In some embodiments, the neuron is generated from an adult fibroblast cell comprising miR-9/9* and miR-124 (miR-9/9-124); and one or more transcription factors. In some embodiments, the transcription factors comprise ISL1 and LHX3 or CTIP2, DLX1, DLX2, and MYT1L (CDM).

Abstract: A surgical instrument is disclosed. The surgical instrument includes an actuation system, a drive system, and a tool head. The drive system is coupled to the actuation system and includes a rotatable shaft which defines a longitudinal axis. The tool head is coupled to the drive system and includes an annular cartridge and a pliable bunchable ring. The annular cartridge includes a plurality of staples. The pliable bunchable ring surrounds the annular cartridge. The surgical instrument is configured to drive the staples through the pliable bunchable ring substantially transverse to the longitudinal axis.

Abstract: Methods and devices are provided for controlling movement of a distal end of a surgical instrument. In general, the methods and devices can allow for controlling movement of surgical tools, and in particular for causing mimicked motion between an external control unit and a surgical tool positioned within a patient's body. In one embodiment, a surgical system is provided having a master assembly including an input tool and a slave assembly including a surgical instrument. The master assembly and the slave assembly can be configured to be electronically coupled together such that movement of the master assembly can be electronically communicated to the slave assembly to cause mimicked movement of the slave assembly.

Abstract: Bowel retractor devices. In various forms, the bowel retractor devices are configurable from a collapsed position wherein the retractor may be inserted through a trocar cannula or other opening in a patient's body to a second expanded position wherein at least a portion of the patient's bowel may be advantageously supported in a desired position.

Abstract: Methods and devices are provided for controlling movement of a distal end of a surgical instrument. In general, the methods and devices can allow for controlling movement of surgical tools, and in particular for causing mimicked motion between an external control unit and a surgical tool positioned within a patient's body. In one embodiment, a surgical system is provided having a master assembly including an input tool and a slave assembly including a surgical instrument. The master assembly and the slave assembly can be configured to be electronically coupled together such that movement of the master assembly can be electronically communicated to the slave assembly to cause mimicked movement of the slave assembly.

Abstract: Methods and devices are provided for controlling movement of a distal end of a surgical instrument. In general, the methods and devices can allow for controlling movement of surgical tools, and in particular for causing mimicked motion between an external control unit and a surgical tool positioned within a patient's body. In one embodiment, a surgical system is provided having a master assembly including an input tool and a slave assembly including a surgical instrument. The master assembly and the slave assembly can be configured to be electronically coupled together such that movement of the master assembly can be electronically communicated to the slave assembly to cause mimicked movement of the slave assembly.

Abstract: Bowel retractor devices. In various forms, the bowel retractor devices are configurable from a collapsed position wherein the retractor may be inserted through a trocar cannula or other opening in a patient's body to a second expanded position wherein at least a portion of the patient's bowel may be advantageously supported in a desired position.

Abstract: Bowel retractor devices. In various forms, the bowel retractor devices are configurable from a collapsed position wherein the retractor may be inserted through a trocar cannula or other opening in a patient's body to a second expanded position wherein at least a portion of the patient's bowel may be advantageously supported in a desired position.

Abstract: Tissue manipulation devices are disclosed. In various forms, the devices include tissue manipulation arms that are arranged in a position suitable to enable the device to be inserted into the colon then, upon application of at least one actuation motion thereto, at least some of the tissue manipulation arms are moved to deployed positions wherein they contact corresponding portions of the colon to thereby expand the colon. Various devices are actuatable by various forms of actuation forces. In various embodiments, the tissue manipulation arms may be movable along corresponding axes that are transverse to an insertion axis and may also be rotated about the insertion axis as well as be moved in directions that are substantially parallel to the insertion axis.

Abstract: Various universal ports for installation into a colon are disclosed. Various embodiments include expandable port bodies that may employ selectively deployable tissue-engaging barbs for securing the port in position within the colon. Some embodiments also employ tissue cutting members that may be deployed to sever the colon. Some embodiments also employ a flexible sleeve that may extend from the port out through the anus to provide a passageway for passing surgical instruments and into and out of the rectum and also for removing severed specimens therefrom.

Abstract: Methods and devices are provided for controlling movement of a distal end of a surgical instrument. In general, the methods and devices can allow for controlling movement of surgical tools, and in particular for causing mimicked motion between an external control unit and a surgical tool positioned within a patient's body. In one embodiment, a surgical system is provided having a master assembly including an input tool and a slave assembly including a surgical instrument. The master assembly and the slave assembly can be configured to be electronically coupled together such that movement of the master assembly can be electronically communicated to the slave assembly to cause mimicked movement of the slave assembly.

Abstract: Methods of converting non-neuronal somatic cells into induced neuronal cells are provided. Aspects of the methods include contacting a non-neuronal somatic cell with a microRNA mediated neuronal cell induction agent. Aspects of the invention further include compositions produced by methods of the invention as well as compositions that find use in practicing embodiments of methods of invention. The methods and compositions find use in a variety of different applications.

Abstract: Bowel retractor devices. In various forms, the bowel retractor devices are configurable from a collapsed position wherein the retractor may be inserted through a trocar cannula or other opening in a patient's body to a second expanded position wherein at least a portion of the patient's bowel may be advantageously supported in a desired position.