Abstract: A pixelated electronic sensor is disclosed for imaging from infra-red to ultraviolet wavelengths, composed of a CMOS integrated circuit plus layers of nano-materials monolithically integrated via low temperature post-processing. Co-design, simulation, and integration methods for the device are described. Each pixel has color-resolved single photon sensitivity without dark counts and without inefficiency. The device operates at temperatures above 70° Kelvin. Current state of the art imagers that can color-resolve single photons are of bolometric or filter type. Bolometric devices must operate at temperature below 1° Kelvin and are limited to few pixels. Devices that use filters are inefficient as all the photons rejected by a filter are wasted. Single photon imagers that operate at non-cryogenic temperature (like Silicon Photomultipliers) have large dark counts typically measured in MHz/cm2.

Abstract: Described herein are compositions and methods for identifying, selecting, or culturing cells comprising a subject nucleic acid sequence of interest. Generally, a nucleic acid comprising a subject nucleic acid and a sequence encoding an enzyme molecule involved in biosynthesis of an amino acid is introduced into a cell. The cell is then grown on media lacking the amino acid, such that cells comprising the introduced nucleic acid are capable of growth. In some instances, the cell further comprises an inhibitor of the enzyme molecule to increase the stringency of the selection.

Abstract: By using the user head and/or eye tracking capabilities of an extended reality (XR) system, a region of gaze (ROG) of the user towards the virtual screen can be determined and signaled to non-XR games and applications running on the host system connected to the XR system. The existing non-XR games/applications can be patched, upgraded, or remastered to support the application of the ROG and ROG based enhancements of the visuals and user interfaces, using the provided by the system software on the host system that is rendering the game for the XR system.

Abstract: A trocar assembly includes a trocar housing that defines a working chamber, and a cannula having opposing proximal and distal ends and defining a lumen that extends between the proximal and distal ends. One or more windows are defined in the cannula at or near the distal end, and one or more compliant deflection devices are arranged at or near the distal end and at least partially receivable within the one or more windows. Each compliant deflection device includes a radial biasing member that extends radially inward toward a centerline of the cannula.

Abstract: This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.

Abstract: Heat sink and heat sink arrangements are provided for an electronic device immersed in a liquid coolant. A heat sink may comprise: a base for mounting on top of a heat-transmitting surface of the electronic device and transferring heat from the heat-transmitting surface; and a retaining wall extending from the base and defining a volume. A heat sink may have a wall arrangement to define a volume, in which the electronic device is mounted. A heat sink may be for an electronic device to be mounted on a surface in a container, in an orientation that is substantially perpendicular to a floor of the container. Heat is transferred from the electronic device to liquid coolant held in the heat sink volume. A cooling module comprising a heat sink is also provided. A nozzle arrangement may direct liquid coolant to a base of the heat sink.

Abstract: Disclosed are systems and methods to determine a direction to a ground fault of an electrical generator or motor using a known steady-state standing error referenced to a positive-sequence voltage measurement to determine a system standing error and utilizing the system standing error to determine an operating current with anomalies attributable to a fault. A ground fault may be determined using zero-sequence voltage signals from the generator or motor installation. The operating current, along with the zero-sequence voltage, may be used to determine a direction to the fault. The generator or motor may be high-impedance grounded. The systems and methods further indicate the direction to a fault where multiple generators or motors are connected to a common bus.

Abstract: A method for predicting eye movement in a head mounted display (HMD). The method including tracking movement of an eye of a user with a gaze tracking system disposed in the HMD at a plurality of sample points. The method including determining velocity of the movement based on the movement of the eye. The method including determining that the eye of the user is in a saccade upon the velocity reaching a threshold velocity. The method including predicting a landing point on the display of the HMD corresponding to a direction of the eye for the saccade.

Abstract: Provided is a method for administering to a subject, via an implantable delivery device, a continuous subcutaneous dose of glucagon-like peptide-1 (GLP-1) analog, where the subject is orally co-administered a drug after implantation of the implantable delivery device and during continuous subcutaneous dosing of the GLP-1 analog.

Abstract: Gaze tracking data representing a user's gaze is analyzed to determine one or more regions of interest. One or more gaze tracking parameters are determined from the gaze tracking data. Adjusted foveation data is determined representing an adjusted size and/or shape of one or more regions of interest in one or more images to be subsequently presented to the user based on the one or more gaze tracking parameters. The compression of the one or more transmitted images is adjusted so that fewer bits are needed to transmit data for portions of an image outside the one or more regions of interest than for portions of the image within the one or more regions of interest. Adjusting compression includes eliminating the region(s) of interest from images that are presented to the user during the saccade or blink.

Abstract: A method for updating information for a graphics pipeline including executing in the first frame period an application on a CPU to generate primitives of a scene for a first video frame. Gaze tracking information is received in a second frame period for an eye of a user. In the second frame period a landing point on an HMD display is predicted at the CPU based at least on the gaze tracking information. A late update of the predicted landing point to a buffer accessible by the GPU is performed in the second frame period. Shader operations are performed in the GPU in the second frame period to generate pixel data based on the primitives and based on the predicted landing point, wherein the pixel data is stored into a frame buffer. The pixel data is scanned out in the third frame period from the frame buffer to the HMD.

Abstract: This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.

Abstract: Gaze tracking data representing a user's gaze is analyzed to determine one or more regions of interest. One or more gaze tracking error parameters are determined from the gaze tracking data including a rate of rotation of a user's eye with respect to one or more axes. An error in a fixation of the user's eye on a particular region of interest is determined. Adjusted foveation data is determined representing an adjusted size and/or shape of one or more regions of interest in one or more images to be subsequently presented to the user based on the one or more gaze tracking parameters. The compression of the one or more transmitted images is adjusted so that fewer bits are needed to transmit data for portions of an image outside the one or more regions of interest than for portions of the image within the one or more regions of interest.

Abstract: By using the user head and/or eye tracking capabilities of an extended reality (XR) system, a region of gaze (ROG) of the user towards the virtual screen can be determined and signaled to non-XR games and applications running on the host system connected to the XR system. The existing non-XR games/applications can be patched, upgraded, or remastered to support the application of the ROG and ROG based enhancements of the visuals and user interfaces, using the provided by the system software on the host system that is rendering the game for the XR system.

Abstract: An apparatus for cooling one or more heat generating components comprises: a sealable enclosure defining a volume for containing a first coolant and one or more heat generating components; a conduit surrounded by the volume, the conduit enabling a second coolant to enter and leave the enclosure, the conduit providing a fluid-tight seal between the first coolant and the second coolant when the first coolant within the volume surrounds the conduit; and a pump within the enclosure configured to direct the first coolant to the conduit such that heat is exchanged between the first coolant and the second coolant.

Abstract: Methods and compositions for the treatment of cancer are provided. The compositions comprise gut bacterial lysates and/or components thereof. The method comprises administration to a subject in need thereof of a gut bacterial lysate. Also provided are methods comprising administration of a gut bacterial lysate in combination with another cancer treatment.

Abstract: A method for updating information for a graphics pipeline including executing in the first frame period an application on a CPU to generate primitives of a scene for a first video frame. Gaze tracking information is received in a second frame period for an eye of a user. In the second frame period a landing point on an HMD display is predicted at the CPU based at least on the gaze tracking information. A late update of the predicted landing point to a buffer accessible by the GPU is performed in the second frame period. Shader operations are performed in the GPU in the second frame period to generate pixel data based on the primitives and based on the predicted landing point, wherein the pixel data is stored into a frame buffer. The pixel data is scanned out in the third frame period from the frame buffer to the HMD.

Abstract: An apparatus for cooling one or more heat generating components comprises: a sealable enclosure defining a volume for containing a first coolant and one or more heat generating components; a conduit surrounded by the volume, the conduit enabling a second coolant to enter and leave the enclosure, the conduit providing a fluid-tight seal between the first coolant and the second coolant when the first coolant within the volume surrounds the conduit; and a pump within the enclosure configured to direct the first coolant to the conduit such that heat is exchanged between the first coolant and the second coolant.

Abstract: Methods and systems for determining a type of material of an object in a real-world environment are described. One of the methods includes receiving a plurality of sets of audio data based on sounds received from a plurality of objects within a plurality of environments. The method further includes receiving a plurality of sets of input data regarding a plurality of types of materials of the plurality of objects, training an artificial intelligence (AI) model based on the plurality of sets of audio data and the plurality of sets of input data, and applying the AI model to a set of audio data captured from the real-world environment to determine the type of material of the object within the real-world environment to enhance the realism of augmented reality (AR) or virtual reality (VR) video games and applications.

Abstract: Heat sink and heat sink arrangements are provided for an electronic device immersed in a liquid coolant. A heat sink may comprise: a base for mounting on top of a heat-transmitting surface of the electronic device and transferring heat from the heat-transmitting surface; and a retaining wall extending from the base and defining a volume. A heat sink may have a wall arrangement to define a volume, in which the electronic device is mounted. A heat sink may be for an electronic device to be mounted on a surface in a container, in an orientation that is substantially perpendicular to a floor of the container. Heat is transferred from the electronic device to liquid coolant held in the heat sink volume. A cooling module comprising a heat sink is also provided. A nozzle arrangement may direct liquid coolant to a base of the heat sink.