Abstract: Provided herein are compositions and methods for driving high expression of a transgene. Compositions and methods for driving high expression of a transgene comprising one or more human-derived regulatory elements, which, when operably linked to a transgene, can result in high expression of the transgene in one or more cell types or tissues.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network to perform any one or more of a variety of machine learning tasks. For example, the neural network can be configured as a generative neural network, e.g., an autoregressive generative neural network.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network to perform any one or more of a variety of machine learning tasks. For example, the neural network can be configured as a generative neural network, e.g., an autoregressive generative neural network.

Abstract: A hand-gesture tracking engine includes a first artificial intelligence (AI) model component configured and trained to automatically identify a hand-gesture made by a source player within a video game. A hand-gesture intent engine includes a second AI model component configured and trained to automatically determine a message for communication to a target player within the video game as conveyed by the hand-gesture identified by the hand-gesture tracking engine. A hand-gesture translation engine having a third AI model component configured and trained to automatically generate a communication to the target player that conveys the message as determined by the hand-gesture intent engine. The third AI model component is configured and trained to automatically control sending of the communication to the target player.

Abstract: Systems and methods for enabling communication between users are described. One of the methods includes receiving, via a computer network, data regarding a plurality of real gestures made by a first user via a first user account. The data regarding the plurality of real gestures is received from a client device. The method further includes determining, from the data, whether a speed of occurrence of the plurality of real gestures is greater than a predetermined speed. After determining that the speed of occurrence of the plurality of real gestures is greater than the predetermined speed, the method includes determining one or more meanings of a combination of the plurality of real gestures. The method includes communicating the one or more meanings of the combination via a virtual avatar, controlled by the first user via the first user account, to a second user.

Abstract: A system may include an energy provision system, a first converter, a second converter, a traction system, and an auxiliary system. The energy provision system may provide a first voltage. The first converter may increase the first voltage from the energy provision system from the first voltage into at least a second voltage. The traction system of a vehicle may be powered by the second voltage from the first converter. The second converter may decrease the first voltage from the energy provision system from the first voltage to a third voltage which may be less than the second voltage. The auxiliary system of the vehicle may be powered by the third voltage from the second converter that may be less than the second voltage.

Abstract: Gaze tracking data representing a user's gaze is analyzed to determine one or more regions of interest. One or more gaze tracking parameters are determined from the gaze tracking data. Adjusted foveation data is determined representing an adjusted size and/or shape of one or more regions of interest in one or more images to be subsequently presented to the user based on the one or more gaze tracking parameters. The compression of the one or more transmitted images is adjusted so that fewer bits are needed to transmit data for portions of an image outside the one or more regions of interest than for portions of the image within the one or more regions of interest. Adjusting compression includes eliminating the region(s) of interest from images that are presented to the user during the saccade or blink.

Abstract: A method of targeting, which involves capturing a first video of a scene about a potential targeting coordinate by a first video sensor on a first aircraft; transmitting the first video and associated potential targeting coordinate by the first aircraft; receiving the first video on a first display in communication with a processor, the processor also receiving the potential targeting coordinate; selecting the potential targeting coordinate to be an actual targeting coordinate for a second aircraft in response to viewing the first video on the first display; and guiding a second aircraft toward the actual targeting coordinate; where positive identification of a target corresponding to the actual targeting coordinate is maintained from selection of the actual targeting coordinate.

Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.

Abstract: Provided herein are methods and systems for sequencing proteins. One or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. The linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. Further processing and analysis may be conducted using, for example, nanopores or nanogaps.

Abstract: Provided herein are compositions and methods for driving high expression of a transgene. Compositions and methods for driving high expression of a transgene comprising one or more human-derived regulatory elements, which, when operably linked to a transgene, can result in high expression of the transgene in one or more cell types or tissues.

Abstract: A paver assembly includes a paving unit assembly having a first side wall, a second side wall, and an expandable frame connecting the first side wall and the second side wall together. The expandable frame can move the first side wall and the second side wall towards and away from one another to contract and expand the paving unit assembly so that a width of the paving unit assembly can be the same as a width of a surface paved by the paver assembly. The paver assembly can also include a first paving unit fixedly connected with respect to the first side wall and a second paving unit fixedly connected with respect to the second side wall, where the first paving unit and the second paving unit are offset with respect to one another and move past one another as the paver assembly expands and contracts.

Abstract: A new and innovative medical sizing instrument and method are provided for determining an appropriate depth and/or length of a clavicle hook plate for a patient. The provided medical sizing instrument may enable a surgeon to determine an appropriate hook depth without having to switch between different components, such as a series of templates. In an example, a surgeon may insert the medical sizing instrument into a patient the same as the surgeon would a clavicle hook plate, adjust the hook depth on the medical sizing instrument until a hook depth is obtained that appropriately maintains the anatomical alignment of the patient's clavicle and acromion, and read an indicated depth on the medical sizing instrument. The surgeon may then remove the medical sizing instrument from the patient and select the appropriate clavicle hook plate to insert into the patient.

Abstract: Provided herein are compositions and methods of use thereof comprising a non-naturally occurring DNA binding protein that modulates expression of an endogenous gene.

Abstract: A pixelated electronic sensor is disclosed for imaging from infra-red to ultraviolet wavelengths, composed of a CMOS integrated circuit plus layers of nano-materials monolithically integrated via low temperature post-processing. Co-design, simulation, and integration methods for the device are described. Each pixel has color-resolved single photon sensitivity without dark counts and without inefficiency. The device operates at temperatures above 70° Kelvin. Current state of the art imagers that can color-resolve single photons are of bolometric or filter type. Bolometric devices must operate at temperature below 1° Kelvin and are limited to few pixels. Devices that use filters are inefficient as all the photons rejected by a filter are wasted. Single photon imagers that operate at non-cryogenic temperature (like Silicon Photomultipliers) have large dark counts typically measured in MHz/cm2.

Abstract: Described herein are compositions and methods for identifying, selecting, or culturing cells comprising a subject nucleic acid sequence of interest. Generally, a nucleic acid comprising a subject nucleic acid and a sequence encoding an enzyme molecule involved in biosynthesis of an amino acid is introduced into a cell. The cell is then grown on media lacking the amino acid, such that cells comprising the introduced nucleic acid are capable of growth. In some instances, the cell further comprises an inhibitor of the enzyme molecule to increase the stringency of the selection.

Abstract: By using the user head and/or eye tracking capabilities of an extended reality (XR) system, a region of gaze (ROG) of the user towards the virtual screen can be determined and signaled to non-XR games and applications running on the host system connected to the XR system. The existing non-XR games/applications can be patched, upgraded, or remastered to support the application of the ROG and ROG based enhancements of the visuals and user interfaces, using the provided by the system software on the host system that is rendering the game for the XR system.

Abstract: A trocar assembly includes a trocar housing that defines a working chamber, and a cannula having opposing proximal and distal ends and defining a lumen that extends between the proximal and distal ends. One or more windows are defined in the cannula at or near the distal end, and one or more compliant deflection devices are arranged at or near the distal end and at least partially receivable within the one or more windows. Each compliant deflection device includes a radial biasing member that extends radially inward toward a centerline of the cannula.

Abstract: This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.

Abstract: Heat sink and heat sink arrangements are provided for an electronic device immersed in a liquid coolant. A heat sink may comprise: a base for mounting on top of a heat-transmitting surface of the electronic device and transferring heat from the heat-transmitting surface; and a retaining wall extending from the base and defining a volume. A heat sink may have a wall arrangement to define a volume, in which the electronic device is mounted. A heat sink may be for an electronic device to be mounted on a surface in a container, in an orientation that is substantially perpendicular to a floor of the container. Heat is transferred from the electronic device to liquid coolant held in the heat sink volume. A cooling module comprising a heat sink is also provided. A nozzle arrangement may direct liquid coolant to a base of the heat sink.