Patents by Inventor Andrew Z. Fire

Andrew Z. Fire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION AND ANALYSIS OF STRUCTURAL VARIATIONS IN GENOMES
    Publication number: 20230287397
    Abstract: Compositions and methods are provided for detection of dynamic loci in a genome. The methods may utilize microfluidic platforms and functionalized polymer matrices to allow determination of mechanisms of cell-type-specific, programmed genomic heterogeneity.
    Type: Application
    Filed: April 10, 2023
    Publication date: September 14, 2023
    Inventors: Massa Shoura, Andrew Z. Fire, Stephen Levene
  • RNA Replication Using Transcription Polymerases
    Publication number: 20220259645
    Abstract: Compositions and methods for amplifying RNA by replication using transcription polymerases are disclosed. Such replicated RNAs can be used in various applications such as RNAi therapeutics, diagnostic probes, RNA sequencing, directed evolution of RNA aptamers without intermediate conversion to DNA, and RNA vaccines. The transcription polymerases comprise T7 bacteriophage RNA polymerase.
    Type: Application
    Filed: July 7, 2020
    Publication date: August 18, 2022
    Inventors: Nimit Jain, Andrew Z. Fire, Lucas R. Blauch, Sindy K. Y. Tang, Karen L. Artiles, Julia T. Garcia-Daou, Y. Whitney Yin, Michal R. Szymanski
  • Genetic inhibition by double-stranded RNA
    Patent number: 8580754
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: November 12, 2013
    Assignees: Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Z. Fire, Stephen A. Kostas, Mary K. Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello
  • Genetic inhibition of double-stranded RNA
    Patent number: 8283329
    Abstract: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 9, 2012
    Assignees: The Carnegie Institution of Washington, The University of Massachusetts
    Inventors: Andrew Z. Fire, Stephen A. Kostas, Mary K. Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello