Abstract: The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

Abstract: Mutant epitopes encoded by cancer genes are virtually always located in the interior of cells, making them invisible to conventional antibodies. We generated single chain variable fragments (scFvs) specific for mutant peptides presented on the cell surface by human leukocyte antigen (HLA) molecules. These scFvs can be converted to full-length antibodies, termed MANAbodies, targeting “Mutation Associated Neo-Antigens” bound to HLA. A phage display library representing a highly diverse array of single-chain variable fragment sequences was first designed and constructed. A competitive selection protocol was then used to identify clones specific for peptides bound to pre-defined HLA types. In this way, we obtained scFvs, including one specific for a peptide encoded by a common KRAS mutant and another by a common EGFR mutant. Molecules targeting MANA can be developed that specifically react with mutant peptide-HLA complexes even when these peptides differ by only one amino acid from the normal, wild-type form.

Abstract: This document relates to methods and materials for treating a mammal having cancer. For example, this document provides T cell receptors (TCRs) that can bind to a modified peptide (e.g., a tumor antigen). In some cases, methods of using T cells expressing one or more TCRs that can bind to a modified peptide (e.g., a tumor antigen) to treat a mammal having cancer are provided.

Abstract: A multi-phase LLC power converter comprises a plurality of LLC phases each including a resonant tank and a switching stage. The resonant tank includes a resonant inductor, a resonant capacitor, and a parallel inductance. The switching stage switches an input power at an operating frequency to apply a switched power to the resonant tank, with the switched power approximating an alternating current (AC) waveform having a switching frequency. A secondary-side controller varies the switching frequency to control an output voltage of the multi-phase LLC power converter. A primary-side controller measures primary-side currents, calculates an initial switch-controlled capacitor (SCC) conduction phase angle for each of the LLC phases, and operates an SCC switch in accordance with an SCC conduction phase angle to adjust the capacitance of the resonant capacitor of an LLC phase to cause each of the LLC phases to have equal resonant frequencies.

Abstract: Embodiments of the present disclosure generally relate to methods and apparatus for measuring and controlling local impedances at a substrate support in a plasma processing chamber during processing of a substrate. A substrate support includes a plurality of substrate support pins wherein the radio frequency voltage, current and phase of each of the plurality of substrate support pins are measured and impedances of the support pins are adjusted in real time. Each of the substrate support pins is coupled to an associated adjustable impedance circuit that may be remotely controlled. In one embodiment a variable capacitor is used to adjust the impedance of the impedance circuit coupled to the associated substrate support pin and may be remotely adjusted with a stepper motor.

Abstract: An embodiment of an integrated circuit may comprise an array of hardware counters, and circuitry communicatively coupled to the array of hardware counters, the circuitry to count accesses to one or more selected pages of a memory with the array of hardware counters. Other embodiments are disclosed and claimed.

Abstract: According to at least one embodiment, a method for providing secondary content, related to primary content, for targeted transmission, includes: receiving a set of user metadata for a plurality of users, the user metadata comprising one or more of user browsing history, purchase history, term usage history, social media posts and actions, or location information; based on the set of user metadata, identifying, via a machine learning model, a subset of the users having an affinity for purchasing digital home-entertainment content, wherein the affinity is above a threshold level; and providing an indication of the subset of users having the affinity above the threshold level.

Abstract: This document relates to methods and materials for treating T cell cancers. For example, a composition containing one or more bispecific molecules targeting T cell receptor £ chain constant region (TRBC) can be administered to a mammal having a T cell cancer to treat the mammal. For example, this document provides methods and materials for using one or more bispecific molecules to treat a mammal having a T cell cancer.

Abstract: A system and method are provided for protecting semiconductor components from thermal failure in an electronic circuit interrupter. The electronic trip unit (ETU) is configured to determine what range of current the detected current signal corresponds to, out of several ranges categorized as being either non-fault/normal, non-severe fault, and severe fault. The ETU then selects a mode of operation in which to operate based on the determined range of current. In modes of operation corresponding to a fault condition, the ETU monitors certain characteristics of the current such as magnitude and/or rate of rise, and if the aforementioned current characteristics exceed a specified threshold for a minimum interval of time, the ETU will trip the electronic interrupter. If, however, the aforementioned current characteristics fall below the specified threshold prior to the minimum interval of time elapsing, the ETU will not trip the electronic interrupter.

Abstract: In an embodiment, an image reception system is communicatively coupled to an image analysis system and is configured to receive a digital image and analyze the pixels of the digital image to determine one or more regions in the digital image. For each region in the one or more regions in the digital image, the image analysis system recognizes the content in the region. A document creation system communicatively coupled to the image analysis system is configured to create a digital document based on the recognized content for the one or more regions. In some embodiments, the image analysis system is further configured to analyze the digital image to detect one or more of the following: region markers, tables, headers.

Abstract: Machine learning, artificial intelligence, and other computer-implemented methods are used to identify various semantically important chunks in documents, automatically label them with appropriate datatypes and semantic roles, and use this enhanced information to assist authors and to support downstream processes. Chunk locations, datatypes, and semantic roles can often be automatically determined from what is here called “context”, to wit, the combination of their formatting, structure, and content; those of adjacent or nearby content; overall patterns of occurrence in a document, and similarities of all these things across documents (mainly but not exclusively among documents in the same document set).

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing neural architecture search for machine learning models. In one aspect, a method comprises receiving training data for a machine learning, generating a plurality of candidate neural networks for performing the machine learning task, wherein each candidate neural network comprises a plurality of instances of a layer block composed of a plurality of layers, for each candidate neural network, selecting a respective type for each of the plurality of layers from a set of layer types that comprises, training the candidate neural network and evaluating performance scores for the trained candidate neural networks as applied to the machine learning task, and determining a final neural network for performing the machine learning task based at least on the performance scores for the candidate neural networks.

Abstract: An integrated circuit apparatus includes a substrate and a well contact that is disposed on the substrate. The well contact includes first and second source/drain structures that are disposed on the substrate; a metal vertical portion that contacts the substrate immediately between the first and second source/drain structures; inner spacers that electrically insulate the vertical portion from the adjacent source/drain structures; bottom dielectric isolation that electrically insulates the source/drain structures from the substrate; and a well portion that is embedded into the substrate in registry with the vertical portion. The well portion is doped differently than the substrate.

Abstract: The presently disclosed subject matter relates to isolated compositions and methods for treating and/or preventing sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). In some embodiments, the presently disclosed subject matter relates to endothelial progenitor cell-derived exosomes to treat and/or prevent sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). The endothelial progenitor cell-derived exosomes can be modified to overexpress one or more miRNAs.

Abstract: A circuit interrupter including a current sensor having a normal sensor output and an over current detection output, a solid state switch module structured to have a closed state to allow current to flow through the circuit interrupter and an open state to interrupt current flowing through the circuit interrupter, a gate driver structured to control the solid state switch module including a desaturation function output, wherein the gate driver is structured to cause the solid state switch module to interrupt current flowing through the circuit interrupter when the DESAT function output changes to the on state, and an electronic trip circuit structured to output a trip signal to the gate driver when the normal sensor output reaches a first threshold level or the overcurrent detection output changes to the on state.

Abstract: Polymeric electro spray emitters and related methods are generally described. In some embodiments, an emitter may be made from an ionic electro active polymer. The composition of the electro spray emitters described herein may enable the transport of ions and/or liquid ion sources, such as an ionic liquid or room temperature molten salt, through the bulk of the polymeric emitter. In some embodiments, the described emitters may be fabricated using a mixture of an ionic electroactive polymer, a solvent, and a liquid ion source to at least partially mitigate swelling effects of the polymer emitter that may otherwise occur when the one or more emitters are exposed to the liquid ion source during operation.

Abstract: Systems and methods are provided for ozonolysis of polycyclic aromatic hydrocarbons (PAHs) in a liquid CO2 reaction environment. It has been unexpectedly discovered that oxygen-containing functional groups can be added to PAH substrates while substantially avoiding combustion reactions and while reducing or minimizing formation of energetic intermediates. Because the formation of energetic intermediates is minimal, the ozonolysis can be performed at temperatures near ambient (e.g., between ?10° C. and 50° C.) while still achieving a satisfactory safety profile. In various aspects, ozonolysis can occur while forming a reduced or minimized amount of water, such as forming substantially no water in the reaction environment.

Abstract: A method and system for determining interaction sites between biosequences is described herein. A dataset of contact data for a plurality of biomolecule pairs is obtained to account their frequency of occurrence. Statistical weights are obtained for each frequency of occurrence. A statistical vector space (SRV) is decomposed through principal component decomposition. The r-vectors of the SRV are re-projected back to a new SRV with a new set of SR coordinates. A feature vector is generated and inputted into a predictor for outputting a likelihood of an interaction site. A method and system for determining significant attribute-value associations (AVAs) from relational datasets is also described. A frequency of occurrence of attribute value pairs and statistical weights may be obtained for each frequency of occurrence. Principal component decomposition and re-projection of AVA vectors may also be performed. The disentangle SR of AVAs could be used to identify AVA related to subgroups/classes.

Abstract: An ice making assembly includes an ice mold and a pump assembly for urging an ice-building spray into the ice mold to form an ice billet. A controller operates the pump assembly to provide the ice-building spray at a first flow rate until the ice billet reaches a predetermined thickness and then operates the pump assembly to provide the ice-building spray at a second flow rate that is less than the first flow rate.

Abstract: Described herein are techniques are provided for enabling a security orchestration, automation, and response (SOAR) service to automatically manage apps used to interface with an integrated security operations service and other related devices and services. Further described herein is a SOAR app generator service or application used to automate the creation of apps for a SOAR service based on application programming interfaces (API) specifications for related devices or services, as well as visual playbook editor interfaces for a SOAR service that enable the configuration of complex action input parameters including arrays and objects.