Abstract: Degradation of the reflectivity of one or more reflective optical elements in a system for generating EUV radiation is reduced by the controlled introduction of a gas into a vacuum chamber containing the optical element. The gas may be added to the flow of another gas such as hydrogen or alternated with the introduction of hydrogen radicals.

Abstract: Systems and methods described herein improve a customer experience by enabling a user equipment (UE) device to accurately display a premium network icon based on network signaling. A network device stores configuration thresholds for supporting a premium cellular service and monitors network conditions against the configuration thresholds. When the network conditions meet at least one of the configuration thresholds, the network device provides to the UE device a signal for the UE device to present a premium network icon to a user.

Abstract: The disclosed computer-implemented method may include accessing various antenna elements and identifying parameters for an antenna that is to be formed using the accessed antenna elements. The method may also include assembling the antenna elements, using an artificial intelligence (AI) instance, into an assembled antenna that at least partially complies with the identified parameters. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Metal object detection may be performed in a wireless power system by monitoring the 5th or other order harmonic current of a dual-frequency power transmitter driven by a voltage-fed inverter with square-wave output. While power transfer is maintained by tuning at the fundamental frequency, the transmitter circuit is tuned simultaneously at the 5th order frequency or other harmonic frequencies to increase or decrease the flow of the harmonic current for when a metal object is present. The receiver circuit may include a notch filter to filter out the 5th order frequency. With the dual-frequency tuning configuration, the presence of a metal object causes a significant drop of the increase in the harmonic current at the transmitter side while the receiver behaves as an open circuit with no effect on power transfer. The harmonic tuning circuit may be switched off as necessary to leave only the fundamental frequency for power transfer.

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in signal amplification. There are provided, in some embodiments, protease-based signal amplification modules. Disclosed herein include amplifier proteins comprising a first part of a first protease domain, a first dimerization domain, a first cut site a protease in a protease active state is capable of cutting, a second dimerization domain, a second cut site a protease in a protease active state is capable of cutting, and a first caging domain. Disclosed herein include companion amplifier proteins comprising a second part of a first protease domain, a third dimerization domain, a third cut site a protease in a protease active state is capable of cutting, a fourth dimerization domain, a fourth cut site a protease in a protease active state is capable of cutting, and a second caging domain.

Abstract: The present disclosure provides directed to new, more efficient neural network architectures. As one example, in some implementations, the neural network architectures of the present disclosure can include a linear bottleneck layer positioned structurally prior to and/or after one or more convolutional layers, such as, for example, one or more depthwise separable convolutional layers. As another example, in some implementations, the neural network architectures of the present disclosure can include one or more inverted residual blocks where the input and output of the inverted residual block are thin bottleneck layers, while an intermediate layer is an expanded representation. For example, the expanded representation can include one or more convolutional layers, such as, for example, one or more depthwise separable convolutional layers. A residual shortcut connection can exist between the thin bottleneck layers that play a role of an input and output of the inverted residual block.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A method to fabricate a three dimensional memory structure may include creating a stack of layers including a conductive source layer, a first insulating layer, a select gate source layer, and a second insulating layer, and an array stack. A hole through the stack of layers may then be created using the conductive source layer as a stop-etch layer. The source material may have an etch rate no faster than 33% as fast as an etch rate of the insulating material for the etch process used to create the hole. A pillar of semiconductor material may then fill the hole, so that the pillar of semiconductor material is in electrical contact with the conductive source layer.

Abstract: Embodiments described herein relate to blended meat substitute products and methods of producing the same. In some aspects, a method of producing a meat substitute product can include providing a plant based scaffolding with a carrier material, the carrier material including animal cells, adding a gelation agent to at least one of the plant-based scaffolding, and incubating the carrier material and the plant-based scaffolding in a controlled environment to produce a meat substitute product. In some embodiments, the animal cells can include at least one of skeletal muscle cells, fat cells, connective tissue cells, or skin cells.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A thermal component has a shield portion and a heat exchanger portion. The shield portion includes a plurality of cells adapted to inhibit radio radiation (RF) having a frequency within a target frequency range, while the heat exchanger portion includes a plurality of elongated channels, each one of the elongated channels being physically connected to and in fluid communication with at least one corresponding cell of the plurality of cells.

Abstract: Presented herein are methods, non-transitory computer readable media, and devices for allocating resources to a particular volume and triggering a consistency point based on the amount given to each volume, thus providing dynamic consistency point triggers. Methods for providing dynamic consistency point triggers are disclosed which include: determining a volume's capacity to utilize resources based on the volume's performance; receiving an allocation of the divided resources based on total system resources available within the storage system and the volume's performance; and triggering a consistency point upon exhausting a threshold percentage of the received/allocated resources.

Abstract: Presented herein are methods, non-transitory computer readable media, and devices for allocating resources to a particular volume and triggering a consistency point based on the amount given to each volume, thus providing dynamic consistency point triggers. Methods for providing dynamic consistency point triggers are disclosed which include: determining a volume's capacity to utilize resources based on the volume's performance; receiving an allocation of the divided resources based on total system resources available within the storage system and the volume's performance; and triggering a consistency point upon exhausting a threshold percentage of the received/allocated resources.