Patents by Inventor Andrey Alexandrovich Arzumanov

Andrey Alexandrovich Arzumanov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell-penetrating peptides having a central hydrophobic domain
    Patent number: 9302014
    Abstract: The present invention discloses cell penetrating peptides (CPP or membrane translocating peptide) and their conjugates with cargo molecules. The peptides are useful as drug delivery systems, particularly as delivery vehicles for nucleotide-based therapeutics, such as polynucleotides, oligonucleotides and peptide nucleic acids. A CPPs of the invention provides a balance between good cell entry efficiency and low toxicity and comprises three contiguous domains: the central one being hydrophobic and the flanking ones consisting of arginine and aminohexanoic acid or beta-alanine residues. The hydrophobic domain contains a sequence selected from YQFLI, YRFLI, IQFLI and IRFLI.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: April 5, 2016
    Assignee: Medical Research Council
    Inventors: Michael John Gait, Andrey Alexandrovich Arzumanov, Amer F. Saleh, Matthew J. A. Wood, Corinne Betts, Taeyoung Koo
  • Cell-Penetrating Peptides Having a Central Hydrophobic Domain
    Publication number: 20140342992
    Abstract: The present invention discloses cell penetrating peptides (CPP or membrane translocating peptide) and their conjugates with cargo molecules. The peptides are useful as drug delivery systems, particularly as delivery vehicles for nucleotide-based theraputics, such as polynucleotides, oligonucleotides and peptide nucleic acids. A CPPs of the invention provides a balance between good cell entry efficency and low toxicity and comprises three contiguous domains: the central one being hydrophobic and the flanking ones consisting of arginine and aminohexanoic acid or beta-alanine residues. The hydrophobic domain contains a sequence selected from YQFLI, YRFLI, IQFLI and IRFLI.
    Type: Application
    Filed: August 29, 2012
    Publication date: November 20, 2014
    Applicant: Medical Research Council
    Inventors: Michael John Gait, Andrey Alexandrovich Arzumanov, Amer F. Saleh, Matthew J.A. Wood, Corinne Betts, Taeyoung Koo
  • CELL PENETRATING PEPTIDES
    Publication number: 20140051646
    Abstract: The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
    Type: Application
    Filed: August 14, 2013
    Publication date: February 20, 2014
    Applicant: Medical Research Council
    Inventors: Michael John Gait, Andrey Alexandrovich Arzumanov, Gabriela Dimitroval Ivanova
  • Cell penetrating peptides
    Patent number: 8575305
    Abstract: The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: November 5, 2013
    Assignee: Medical Research Council
    Inventors: Michael John Gait, Andrey Alexandrovich Arzumanov, Gabriela Dimitroval Ivanova
  • PEPTIDES
    Publication number: 20110105403
    Abstract: The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
    Type: Application
    Filed: May 15, 2009
    Publication date: May 5, 2011
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Michael John Gait, Andrey Alexandrovich Arzumanov, Gabriela Dimitroval Ivanova