Patents by Inventor Andrey G. Sarafanov

Andrey G. Sarafanov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FACTOR VIII COMPOSITIONS AND METHODS
    Publication number: 20100167392
    Abstract: The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It further provides methods for producing such factor VIII mutants. The invention also provides polynucleotides encoding the mutant factor VIII, and methods of treating hemophilia using the polypeptides and polynucleotides of the invention.
    Type: Application
    Filed: October 2, 2009
    Publication date: July 1, 2010
    Applicant: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Evgueni L. SAENKO, Andrey G. Sarafanov, Natalya M. Ananyeva
  • Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII
    Patent number: 7615622
    Abstract: The present invention provides methods of increasing the half-life factor VIII. More specifically, the invention methods of increasing the half-life of factor VIII by substituting amino acids in the A2 domain or in the C2 domain of factor VIII or in both domains. It further provides factor VIII mutants produced by these methods. The invention also provides a method of using receptor-associated protein (RAP) to increase the half-life of factor VIII. The invention also provides polynucleotides encoding the mutant factor VIII, polynucleotides encoding RAP, and methods of treating hemophilia using the polypeptides and polynucleotides of the invention.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: November 10, 2009
    Assignee: University of Maryland, Baltimore
    Inventors: Evgueni L. Saenko, Andrey G Sarafanov
  • Factor VIII compositions and methods
    Patent number: 7211559
    Abstract: The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It further provides methods for producing such factor VIII mutants. The invention also provides polynucleotides encoding the mutant factor VIII, and methods of treating hemophilia using the polypeptides and polynucleotides of the invention.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: May 1, 2007
    Assignee: University of Maryland, Baltimore
    Inventors: Evgueni L. Saenko, Andrey G. Sarafanov, Natalya M. Ananyeva
  • Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor viii
    Publication number: 20040248785
    Abstract: The present invention provides methods of increasing the half-life factor VIII. More specifically, the invention methods of increasing the half-life of factor VIII by substituting amino acids in the A2 domain or in the C2 domain of factor VIII or in both domains. It further provides factor VIII mutants produced by these methods. The invention also provides a method of using receptor-associated protein (RAP) to increase the half-life of factor VIII. The invention also provides polynucleotides encoding the mutant factor VIII, polynucleotides encoding RAP, and methods of treating hemophilia using the polypeptides and polynucleotides of the invention.
    Type: Application
    Filed: May 26, 2004
    Publication date: December 9, 2004
    Inventors: Evgueni L. Saenko, Andrey G. Sarafanov