Patents by Inventor Andrey KOVALEVSKY

Andrey KOVALEVSKY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Centrally active and orally bioavailable uncharged bisoxime antidotes for organophosphate poisoning and methods for making and using them
    Patent number: 11820749
    Abstract: In alternative embodiments, provided are uncharged bis-oxime antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). In alternative embodiments, provided are pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi-chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound as provided herein.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: November 21, 2023
    Assignees: The Regents of the University of California, Oak Ridge National Laboratory
    Inventors: Zoran Radic, Carlo Ballatore, Lukas Gorecki, Palmer Taylor, Andrey Kovalevsky, Xiaolin Cheng
  • CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE UNCHARGED BISOXIME ANTIDOTES FOR ORGANOPHOSPHATE POISONING AND METHODS FOR MAKING AND USING THEM
    Publication number: 20220227724
    Abstract: In alternative embodiments, provided are uncharged bis-oxime antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). In alternative embodiments, provided are pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi-chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound as provided herein.
    Type: Application
    Filed: May 21, 2020
    Publication date: July 21, 2022
    Inventors: Zoran RADIC, Carlo BALLATORE, Lukas GORECKI, Palmer TAYLOR, Andrey KOVALEVSKY, Xiaolin CHENG