Patents by Inventor Andries J.C. Steyn

Andries J.C. Steyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarkers for Tuberculosis and HIV/AIDS
    Publication number: 20140369998
    Abstract: Described herein is a diagnostic test that identifies circulating biomarkers for the differentiation and classification of the pathogenesis of TB and/or HIV in a population.
    Type: Application
    Filed: December 9, 2011
    Publication date: December 18, 2014
    Inventors: Andries J.C. Steyn, Michael Kimerling, German Henostroza, David K. Crossman
  • Mycobacterial Disease Detection, Treatment, and Drug Discovery
    Publication number: 20140163078
    Abstract: Methods for detecting and treating Mycobacterium-related diseases including reducing Mycobacterial virulence, reducing RV3133c dimerization, and treating a subject with a Mycobacterial infection using identified compounds are disclosed. Examples of compounds useful in the treatment of Mycobacterium-related diseases include N-(4-[(acetylamino)sulfonyl]phenyl)-3-phenylpropanamide; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1yl)ethanone hydrochloride; and 1-(1,3-benzoxazol-2-yl)-3-({4-[(2-hydroxyethyl)sulfonyl]phenyl}amino)acrylaldehyde. Further disclosed are methods for identifying agents that interact with a polypeptide in a Mycobacterium cell.
    Type: Application
    Filed: November 21, 2013
    Publication date: June 12, 2014
    Applicant: The UAB Research Foundation
    Inventors: Andries J.C. Steyn, Deborah Mai, Amit Singh
  • Mycobacterial disease detection, treatment, and drug discovery
    Patent number: 8603751
    Abstract: Methods for detecting and treating Mycobacterium-related diseases including reducing Mycobacterial virulence, reducing RV3133c dimerization, and treating a subject with a Mycobacterial infection using identified compounds are disclosed. Examples of compounds useful in the treatment of Mycobacterium-related diseases include N-(4-[(acetylamino)sulfonyl]phenyl)-3-phenylpropanamide; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1yl)ethanone hydrochloride; and 1-(1,3-benzoxazol-2-yl)-3-({4-[(2-hydroxyethyl)sulfonyl]phenyl}amino)acrylaldehyde. Further disclosed are methods for identifying agents that interact with a polypeptide in a Mycobacterium cell.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: December 10, 2013
    Assignee: The UAB Research Foundation
    Inventors: Andries J. C. Steyn, Deborah Mai, Amit Singh
  • MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY
    Publication number: 20090068197
    Abstract: Methods for detecting and treating Mycobacterium-related diseases including reducing Mycobacterial virulence, reducing RV3133c dimerization, and treating a subject with a Mycobacterial infection using identified compounds are disclosed. Examples of compounds useful in the treatment of Mycobacterium-related diseases include N-(4-[(acetylamino)sulfonyl]phenyl)-3-phenylpropanamide; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1yl)ethanone hydrochloride; and 1-(1,3-benzoxazol-2-yl)-3-({4-[(2-hydroxyethyl)sulfonyl]phenyl}amino)acrylaldehyde. Further disclosed are methods for identifying agents that interact with a polypeptide in a Mycobacterium cell.
    Type: Application
    Filed: March 1, 2007
    Publication date: March 12, 2009
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Andries J.C. Steyn, Deborah Mai, Amit Singh