Patents by Inventor Andrzej Fertala

Andrzej Fertala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED ANTIBODY FOR INHIBITION OF FIBROSIS
    Publication number: 20220185873
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Application
    Filed: December 21, 2021
    Publication date: June 16, 2022
    Inventors: Andrzej Fertala, Andrzej Steplewski
  • Engineered antibody for inhibition of fibrosis
    Patent number: 11208472
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: December 28, 2021
    Assignee: Thomas Jefferson University
    Inventors: Andrzej Fertala, Andrzej Steplewski
  • ENGINEERED ANTIBODY FOR INHIBITION OF FIBROSIS
    Publication number: 20200095308
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Application
    Filed: December 6, 2019
    Publication date: March 26, 2020
    Inventors: Andrzej Fertala, Andrzej Steplewski
  • ANTIGEN-BINDING DOMAINS OF THE MONOCLONAL ANTI-COLLAGEN I ANTIBODY
    Publication number: 20200048333
    Abstract: An anti-fibrotic biologic comprising, a full-length chimeric IgG variant, a humanized IgG variant, a scFv variant, or other active biologic including the entire CDRs or their fragments able to bind to the ?2Ct target.
    Type: Application
    Filed: October 26, 2017
    Publication date: February 13, 2020
    Inventors: Andrzej FERTALA, Andrzej STEPLEWSKI
  • Engineered antibody for inhibition of fibrosis
    Patent number: 10501533
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: December 10, 2019
    Assignee: Thomas Jefferson University
    Inventors: Andrzej Fertala, Andrzej Steplewski
  • ENGINEERED ANTIBODY FOR INHIBITION OF FIBROSIS
    Publication number: 20180072799
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 15, 2018
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Andrzej Fertala, Andrzej Steplewski
  • Engineered antibody for inhibition of fibrosis
    Patent number: 9777055
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: October 3, 2017
    Assignee: Thomas Jefferson University
    Inventors: Andrzej Fertala, Andrzej Steplewski
  • ENGINEERED ANTIBODY FOR INHIBITION OF FIBROSIS
    Publication number: 20150071926
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Application
    Filed: February 26, 2013
    Publication date: March 12, 2015
    Inventors: Andrzej Fertala, Andrzej Steplewski
  • Inhibitors of collagen assembly
    Patent number: 7018803
    Abstract: The invention relates to peptides and peptidomimetics which inhibit assembly of human type I collagen. Methods of identifying such peptides and peptidomimetics are also included in the invention.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: March 28, 2006
    Assignee: Drexel University College of Medicine
    Inventors: Darwin J. Prockop, Andrzej Fertala
  • Collagen or collagen-like peptide containing polymeric matrices
    Patent number: 6753311
    Abstract: Tissue engineering scaffolds comprising collagen or a collagen-like peptides incorporated within or between polymeric fibers and methods for their production are provided.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: June 22, 2004
    Assignee: Drexel University
    Inventors: Andrzej Fertala, Frank Ko
  • Recombinant collagen-like proteins
    Publication number: 20040115771
    Abstract: The present invention relates generally to collagen proteins, and particularly to recombinant collagen-like proteins consisting of multiple homogeneous domains with high density of biologically active sites.
    Type: Application
    Filed: September 25, 2003
    Publication date: June 17, 2004
    Applicant: Thomas Jefferson University
    Inventor: Andrzej Fertala
  • Inhibitors of collagen assembly
    Publication number: 20030087315
    Abstract: The invention relates to peptides and peptidomimetics which inhibit assembly of human type I collagen. Methods of identifying such peptides and peptidomimetics are also included in the invention.
    Type: Application
    Filed: October 24, 2002
    Publication date: May 8, 2003
    Applicant: MCP Hahnemann University
    Inventors: Darwin J. Prockop, Andrzej Fertala
  • Collagen or collagen-like peptide containing polymeric matrices
    Publication number: 20030021821
    Abstract: Tissue engineering scaffolds comprising collagen or a collagen-like peptides incorporated within or between polymeric fibers and methods for their production are provided.
    Type: Application
    Filed: June 28, 2001
    Publication date: January 30, 2003
    Inventors: Andrzej Fertala, Frank Ko
  • Inhibitors of collagen assembly
    Patent number: 6472504
    Abstract: The invention relates to peptides and peptidomimetics which inhibit assembly of human type I collagen. Methods of identifying such peptides and peptidomimetics are also included in the invention.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: October 29, 2002
    Assignee: MCP Hahnemann University
    Inventors: Darwin J. Prockop, Andrzej Fertala
  • SYNTHESIS OF HUMAN PROCOLLAGENS AND COLLAGENS IN RECOMBINANT DNA SYSTEMS
    Publication number: 20020098578
    Abstract: The invention is transfected cells, substantially all of which contain at least one human collagen gene and express fibrillar collagen molecules derived using methods for synthesizing collagen and collagen fibrils in said cell lines, and methods for treatment of disorders in humans using said collagen derived from said stable cell lines.
    Type: Application
    Filed: February 22, 1999
    Publication date: July 25, 2002
    Inventors: DARWIN J. PROCKOP, LEENA ALA-KOKKO, ANDRZEJ FERTALA, ALEKSANDER SIERON, KARI I. KIVIRIKKO, AMY GEDDIS, TAINA PIHLAJANIEMI
  • Synthesis of human procollagens and collagens in recombinant DNA systems
    Patent number: 5593859
    Abstract: The invention is transfected cells, substantially all of which contain at least one human collagen gene and express fibrillar collagen molecules derived using methods for synthesizing collagen and collagen fibrils in said cell lines, and methods for treatment of disorders in humans using said collagen derived from said stable cell lines.
    Type: Grant
    Filed: August 11, 1994
    Date of Patent: January 14, 1997
    Assignee: Thomas Jefferson University
    Inventors: Darwin J. Prockop, Leena Ala-Kokko, Andrzej Fertala, Aleksander Sieron, Kari I. Kivirikko, Amy Geddis, Taina Pihlajaniemi
  • Synthesis of human procollagens and collagens in recombinant DNA systems
    Patent number: 5405757
    Abstract: The invention is stably transfected cells, substantially all of which contain at least one human collagen gene and express fibrillar collagen molecules derived using methods for synthesizing collagen and collagen fibrils in said cell lines, and methods for treatment of disorders in humans using said collagen derived from said stable cell lines.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: April 11, 1995
    Assignee: Thomas Jefferson University
    Inventors: Darwin J. Prockop, Leena Ala-Kokko, Andrzej Fertala, Aleksander Sieron, Kari I. Kivirikko, Amy Geddis
  • Engineered antibody for inhibition of fibrosis
    Patent number: RE49477
    Abstract: A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the ?2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: March 28, 2023
    Assignee: Thomas Jefferson University
    Inventors: Andrzej Fertala, Andrzej Steplewski