Patents by Inventor Andrzej Kutner

Andrzej Kutner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing all-trans retinoyl CoA
    Patent number: 4966965
    Abstract: The invention relates to a new method for preparing all trans retinoyl CoA.
    Type: Grant
    Filed: March 23, 1989
    Date of Patent: October 30, 1990
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Andrzej Kutner, Heinrich K. Schnoes
  • Compounds effective in inducing cell differentiation and process for preparing same
    Patent number: 4927815
    Abstract: This invention provides novel side chain homologs of 1.alpha.,25-dihydroxyvitamin D.sub.3 which exhibit enhanced and highly selective activity in inducing differentiation of malignant cells. It also provides a general method of synthesis applicable to the preparation of a variety of vitamin D side chain analogs, and a method of treatment of neoplastic diseases which takes advantage of the selective differentiation activity of the new vitamin D homologs.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: May 22, 1990
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman, Andrzej Kutner
  • Process for the production of 1,3,2-oxazaphosphorinanes
    Patent number: 4908464
    Abstract: Process for production of derivatives of 1,3,2-oxazaphosphorinane of general formula 1, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atom or 2-halogenoalkyl group, and R.sub.1 and R.sub.2 are not at the same time hydrogen atoms, and X represents halogen atom is based, according to the invention, on the reduction of the respective 3-halogenoacyl derivatives of 1,3,2-oxazaphosphorinane of general formula 2, ##STR2## wherein the substituents have the above given meaning. The reduction is accomplished with the use of sodium borohydride in the presence of boron trifluoride etherate.Derivatives that are prepared by the procedure described here demonstrate antitumor activity.
    Type: Grant
    Filed: June 9, 1988
    Date of Patent: March 13, 1990
    Assignees: Instytut Przemyslu Farmaceutycznego, Centrum Baden Molekularnych i Makromolekularnych -PAN, Instytut Immunologii i Terapii Doswiadczalnej -PAN
    Inventors: Wojciech J. Stec, Czeslaw Radzikowski, Wieslaw Szelejewski, Ryszard Kinas, Konrad Misiura, Grzegorz Grynkiewicz, Jacek Grodner, Halina Kusnierczyk, Andrzej Kutner, Slawomira Pilichowska
  • Novel cyclopentano-vitamin D analogs
    Patent number: 4851401
    Abstract: This invention provides novel 1.alpha.-hydroxyvitamin D compounds, methods for their preparation, and pharmaceutical compositions of these compounds. The new compounds, which are characterized structurally by having a cyclopentane ring as part of their side chains, exhibit highly pronounced biological activity, both in terms of their effect on calcium metabolism and their effect on differentiating malignant cells to normal cells. By virtue of their biological properties, the new vitamin D analogs are effective as calcium-regulating, or differentiation-inducing agents, and thus find application as therapeutic agents in the treatment or prophylaxis of bone-related as well as neoplastic diseases.
    Type: Grant
    Filed: July 14, 1988
    Date of Patent: July 25, 1989
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman, Andrzej Kutner
  • Vitamin D related compounds and processes for their preparation
    Patent number: 4847012
    Abstract: The invention relates to a method for preparing vitamin D-related compounds and to certain intermediate compounds in such process. The intermediate compounds are characterized by an aldehyde or ester in the C-22 position in the side chain. The presence of such groups permit facile side chain additions for the preparation of vitamin D derivatives.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: July 11, 1989
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Andrzej Kutner, Kato L. Perlman, Rafal R. Sicinski, Mary E. Phelps
  • Method for preparing coenzyme a esters of all-trans- and 13-cis retinoic acids
    Patent number: 4841038
    Abstract: The invention relates to a new method for preparing all trans- and 13-cis retinoyl CoA.
    Type: Grant
    Filed: May 5, 1988
    Date of Patent: June 20, 1989
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Andrzej Kutner, Heinrich K. Schnoes
  • Coenzyme a derivatives of all-trans- and 13-cis retionic acid
    Patent number: 4757140
    Abstract: The invention relates to new coenzyme A and N-hydroxysuccinimidyl esters of all-trans- and 13-cis-retinoic acid and to methods for preparing the same. A new method for preparing all-trans-retinoic acid anhydride is also disclosed.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: July 12, 1988
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Andrzej Kutner, Heinrich K. Schnoes