Patents by Inventor Andrzej Rajca

Andrzej Rajca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Brush-arm star polymer imaging agents and uses thereof
    Patent number: 11752221
    Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field 1H MRI techniques.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: September 12, 2023
    Assignees: Massachusetts Institute of Technology, Board of Regents of the University of Nebraska
    Inventors: Jeremiah A. Johnson, Hung Vanthanh Nguyen, Andrzej Rajca
  • BRUSH-ARM STAR POLYMER IMAGING AGENTS AND USES THEREOF
    Publication number: 20190038782
    Abstract: Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitroxide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field 1H MRI techniques.
    Type: Application
    Filed: June 29, 2018
    Publication date: February 7, 2019
    Inventors: Jeremiah A. Johnson, Hung Vanthanh Nguyen, Andrzej Rajca
  • Oligothiophenes and synthesis thereof
    Patent number: 6515144
    Abstract: Novel oligothiophenes and intermediates therefor are disclosed together with a process for synthesizing them. The oligothiophenes are in the form of a helix which contains five-membered rings unsaturated heterocycles that are cross-conjugated and annelated into a helix.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: February 4, 2003
    Assignee: The Board of Regents of the University of Nebraska
    Inventor: Andrzej Rajca
  • OLIGOTHIOPHENES AND SYNTHESIS THEREOF
    Publication number: 20020193611
    Abstract: Novel oligothiophenes and intermediates therefor are disclosed together with a process for synthesizing them. The oligothiophenes are in the form of a helix which contains five-membered rings unsaturated heterocycles that are cross-conjugated and annelated into a helix.
    Type: Application
    Filed: May 22, 2001
    Publication date: December 19, 2002
    Inventor: Andrzej Rajca