Patents by Inventor Andrzej Z. Sledziewski
Andrzej Z. Sledziewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020173621Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: ApplicationFiled: September 18, 2001Publication date: November 21, 2002Applicant: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel
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Patent number: 6323323Abstract: Ligand-binding, dimerized polypeptide fusions comprising two polypeptide chains are disclosed. Each of the polypeptide chains comprises a ligand-binding domain of either a growth factor receptor or a hormone receptor joined to an immunoglobulin constant region polypeptide. Dimerization of the polypeptide fusion results in enhancement of biological activity. The immunoglobulin constant region polypeptide may comprise an immunoglobulin heavy chain constant region domain and hinge region.Type: GrantFiled: October 25, 1999Date of Patent: November 27, 2001Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel
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Patent number: 6300099Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: GrantFiled: May 30, 2000Date of Patent: October 9, 2001Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel
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Patent number: 6291212Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: GrantFiled: May 30, 2000Date of Patent: September 18, 2001Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel
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Patent number: 6291646Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: GrantFiled: May 30, 2000Date of Patent: September 18, 2001Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel
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Patent number: 6018026Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: GrantFiled: November 26, 1997Date of Patent: January 25, 2000Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel
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Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
Patent number: 5843725Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: GrantFiled: June 7, 1995Date of Patent: December 1, 1998Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel -
Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
Patent number: 5750375Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: GrantFiled: June 7, 1995Date of Patent: May 12, 1998Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian Anne Bell, Wayne R. Kindsvogel -
Patent number: 5576210Abstract: Methods are disclosed for producing hybrid G protein-coupled receptors. DNA sequences encoding hybrid G protein-coupled receptors are provided, wherein the receptors comprise mammalian G protein-coupled receptors having at least one domain other than the ligand-binding domain replaced with a corresponding domain of a yeast G protein-coupled receptor. DNA constructs comprising the following operatively linked elements: a transcriptional promoter, a DNA sequence encoding a hybrid G protein-coupled receptor, wherein the receptor comprises a mammalian G protein-coupled receptor having at least one domain other than the ligand-binding domain replaced with a corresponding domain of a yeast G protein-coupled receptor, and a transcriptional terminator. Host cells transformed with the DNA constructs and methods utilizing the transformed cells are also provided.Type: GrantFiled: February 7, 1994Date of Patent: November 19, 1996Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Paul O. Sheppard
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Patent number: 5567584Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: GrantFiled: January 11, 1994Date of Patent: October 22, 1996Assignee: Zymogenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian A. Bell, Wayne R. Kindsvogel
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Patent number: 5284746Abstract: Methods are disclosed for producing hybrid G protein-coupled receptors. DNA sequences encoding hybrid G protein-coupled receptors are provided, wherein the receptors comprise mammalian G protein-coupled receptors having at least one domain other than the ligand-binding domain replaced with a corresponding domain of a yeast G protein-coupled receptor. DNA constructs comprising the following operatively linked elements: a transcriptional promoter, a DNA sequence encoding a hybrid G protein-coupled receptor, wherein the receptor comprises a mammalian G protein-coupled receptor having at least one domain other than the ligand-binding domain replaced with a corresponding domain of a yeast G protein-coupled receptor, and a transcriptional terminator. Host cells transformed with the DNA constructs and methods utilizing the transformed cells are also provided.Type: GrantFiled: February 8, 1990Date of Patent: February 8, 1994Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Paul O. Sheppard
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Patent number: 5200510Abstract: Methods for purifying factor VIII:C, von Willebrand factor (vWF) or complexes thereof from heterogeneous biological fluids are disclosed. The methods utilize a binding peptide, specific to either factor VIII:C or vWF, bound to an insoluble matrix. Peptides suitable for use within the methods are also disclosed.Type: GrantFiled: March 2, 1988Date of Patent: April 6, 1993Assignee: ZymoGenetics, Inc.Inventors: Anur A. Kumar, Frederick S. Hagen, Andrzej Z. Sledziewski
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Patent number: 5155027Abstract: Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.Type: GrantFiled: May 2, 1989Date of Patent: October 13, 1992Assignee: ZymoGenetics, Inc.Inventors: Andrzej Z. Sledziewski, Lillian A. Bell, Wayne R. Kindsvogel