Patents by Inventor Andy C. Neilson
Andy C. Neilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10359418Abstract: Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that remains in equilibrium with, e.g., remains submerged within, the liquid cell media during the performance of a measurement and during addition of one or more cell affecting fluids such as solutions of potential drug compounds.Type: GrantFiled: August 19, 2015Date of Patent: July 23, 2019Assignee: SEAHORSE BIOSCIENCEInventors: Jay S. Teich, Andy C. Neilson, Stephen C. Young, Jim Orrell
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Patent number: 9494577Abstract: An apparatus including a plurality of wells for conducting analysis of three-dimensional cell samples (e.g., tissue samples) and methods for experimenting with a three-dimensional sample. A removable insert for use with the apparatus enables plunger-driven perfusion of the three-dimensional sample.Type: GrantFiled: November 13, 2013Date of Patent: November 15, 2016Assignee: Seahorse BiosciencesInventors: Paul McGarr, Andy C. Neilson, Jay S. Teich
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Publication number: 20160096173Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: ApplicationFiled: September 18, 2015Publication date: April 7, 2016Inventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Publication number: 20160077083Abstract: Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that remains in equilibrium with, e.g., remains submerged within, the liquid cell media during the performance of a measurement and during addition of one or more cell affecting fluids such as solutions of potential drug compounds.Type: ApplicationFiled: August 19, 2015Publication date: March 17, 2016Inventors: Jay S. Teich, Andy C. Neilson, Stephen C. Young, Jim Orrell
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Patent number: 9170255Abstract: Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that remains in equilibrium with, e.g., remains submerged within, the liquid cell media during the performance of a measurement and during addition of one or more cell affecting fluids such as solutions of potential drug compounds.Type: GrantFiled: January 8, 2014Date of Patent: October 27, 2015Assignee: Seahorse BioscienceInventors: Jay S. Teich, Andy C. Neilson, Stephen G. Young, Jim Orrell
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Patent number: 9170253Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: GrantFiled: March 4, 2014Date of Patent: October 27, 2015Assignee: Seahorse BioscienceInventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Publication number: 20140248650Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: ApplicationFiled: March 4, 2014Publication date: September 4, 2014Applicant: Seahorse BioscienceInventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Publication number: 20140186876Abstract: Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that remains in equilibrium with, e.g., remains submerged within, the liquid cell media during the performance of a measurement and during addition of one or more cell affecting fluids such as solutions of potential drug compounds.Type: ApplicationFiled: January 8, 2014Publication date: July 3, 2014Applicant: Seahorse BioscienceInventors: Jay S. Teich, Andy C. Neilson, Stephen G. Young, Jim Orrell
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Publication number: 20140170671Abstract: An apparatus including a plurality of wells for conducting analysis of three-dimensional cell samples (e.g., tissue samples) and methods for experimenting with a three-dimensional sample. A removable insert for use with the apparatus enables plunger-driven perfusion of the three-dimensional sample.Type: ApplicationFiled: November 13, 2013Publication date: June 19, 2014Applicant: Seahorse BioscienceInventors: Paul McGarr, Andy C. Neilson, Jay S. Teich
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Patent number: 8697431Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: GrantFiled: May 19, 2010Date of Patent: April 15, 2014Assignee: Seahorse Bioscience, Inc.Inventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Patent number: 8658349Abstract: Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that remains in equilibrium with, e.g., remains submerged within, the liquid cell media during the performance of a measurement and during addition of one or more cell affecting fluids such as solutions of potential drug compounds.Type: GrantFiled: July 13, 2006Date of Patent: February 25, 2014Assignee: Seahorse BioscienceInventors: Jay S. Teich, Andy C. Neilson, Stephen C. Young, Jim Orrell
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Patent number: 8202702Abstract: The accuracy and/or precision of measurements of extracellular acidification rate or CO2 evolution in cell culture medium may be improved by using materials with low CO2 permeability for medium-containing vessels.Type: GrantFiled: October 14, 2009Date of Patent: June 19, 2012Assignee: Seahorse BioscienceInventors: Andy C. Neilson, Suzanne Armitstead, Yevgeniy Margolin, Stephen C. Young
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Patent number: 7851201Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: GrantFiled: November 9, 2009Date of Patent: December 14, 2010Assignee: Seahorse Bioscience, Inc.Inventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Publication number: 20100227385Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: ApplicationFiled: May 19, 2010Publication date: September 9, 2010Inventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Publication number: 20100124761Abstract: The accuracy and/or precision of measurements of extracellular acidification rate or CO2 evolution in cell culture medium may be improved by using materials with low CO2 permeability for medium-containing vessels.Type: ApplicationFiled: October 14, 2009Publication date: May 20, 2010Inventors: Andy C. Neilson, Suzanne Armitstead, Yevgeniy Margolin, Stephen C. Young
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Publication number: 20100105578Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: ApplicationFiled: November 9, 2009Publication date: April 29, 2010Applicant: Seahorse BioscienceInventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Patent number: 7638321Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: GrantFiled: June 1, 2007Date of Patent: December 29, 2009Assignee: Seahorse Bioscience, Inc.Inventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Patent number: 7276351Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: GrantFiled: October 17, 2003Date of Patent: October 2, 2007Assignee: Seahorse BioscienceInventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Patent number: 6991765Abstract: Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.Type: GrantFiled: February 5, 2001Date of Patent: January 31, 2006Assignee: FLIR Systems Boston, Inc.Inventors: Andy C. Neilson, Jay S. Teich
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Patent number: 6835574Abstract: Apparatus and methods for performing calorimetry. The apparatus include optical devices for detecting thermal processes and multiwell sample plates for supporting samples for use with such optical devices. The methods include measurement strategies and data processing techniques for reducing noise in measurements of thermal processes. The apparatus and methods may be particularly suitable for extracting thermal data from small differential measurements made using an infrared camera and for monitoring chemical and physiological processes.Type: GrantFiled: February 5, 2001Date of Patent: December 28, 2004Assignee: FLIR Systems Boston, Inc.Inventors: Andy C. Neilson, Michael R. Sweeney, James D. Orrell, III, Michael W. Oster, John M. Hopkins, Marc Samson