Patents by Inventor Andy D. White

Andy D. White has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metabolically stable prodrugs
    Patent number: 12397058
    Abstract: Provided are prodrugs of various therapeutic agents that provide enhanced bioavailability of the therapeutic agent, and methods of treatment conditions in a subject by administration of the one or prodrugs. As provided herein a prodrug includes a therapeutic agent covalently attached to a cap, the cap having a structure according to formula (I) where: R1 is a branched or linear substituted or unsubstituted C2-C6 alkyl, alkenyl, or alkynl; X is —S(0)2-; R2 is a branched or linear substituted or unsubstituted C4-C20 alkyl, alkenyl, or alkynyl; and R3 is —H, C3-C5 cycloalkyl, C3-C5 cycloheteroalkyl, —C(CH3)3, —CF3, —C(CF3)3, or a substituted or unsubstituted phenyl.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: August 26, 2025
    Assignees: TSRL, Inc., Regents of the University of Michigan
    Inventors: Elke Lipka, Eric Simon, Andy D. White, Kim M. Hutchings, Xinmin Gan
  • METABOLICALLY STABLE PRODRUGS
    Publication number: 20210401992
    Abstract: Provided are prodrugs of various therapeutic agents that provide enhanced bioavailability of the therapeutic agent, and methods of treatment conditions in a subject by administration of the one or prodrugs. As provided herein a prodrug includes a therapeutic agent covalently attached to a cap, the cap having a structure according to formula (I) where: R1 is a branched or linear substituted or unsubstituted C2-C6 alkyl, alkenyl, or alkynl; X is —S(0)2-; R2 is a branched or linear substituted or unsubstituted C4-C20 alkyl, alkenyl, or alkynyl; and R3 is —H, C3-C5 cycloalkyl, C3-C5 cycloheteroalkyl, —C(CH3)3, —CF3, —C(CF3)3, or a substituted or unsubstituted phenyl.
    Type: Application
    Filed: June 26, 2019
    Publication date: December 30, 2021
    Applicants: TSRL, Inc., Regents of the University of Michigan
    Inventors: Elke D. Lipka, Eric Simon, Andy D. White, Kim M. Hutchings, Xinmin Gan