Abstract: A powdered tocopheryl polyethylene glycol succinate (TPGS™) having an average particle size of less than about 1000 microns. In one embodiment, the powdered tocopheryl polyethylene glycol succinate is prepared by a process that includes atomizing a fluidic tocopheryl polyethylene glycol succinate into an environment suitable for solidifying the atomized tocopheryl polyethylene glycol succinate. In another embodiment, the powdered tocopheryl polyethylene glycol succinate is prepared by a process of applying a force to a solid tocopheryl polyethylene glycol succinate starting material that is sufficient to produce a powdered product.

Abstract: An eutectic composition having from about 10 to about 90 weight % of a first component comprising a pharmaceutically acceptable substituted C6-C10 aryl compound wherein the aryl moiety includes a straight or branched moiety selected from the group consisting of C1-C12 alkyl, C1-C12 alkoxy, C2-C6 alkanoyloxy, hydroxy, carboxy, carboxy substituted C1-C12 alkyl and mixtures and isomers thereof. The composition also includes from about 10 to 90 weight % of a second component comprising a water-soluble preparation of a fat-soluble vitamin. Also disclosed is a method for preparing the eutectic composition of the present invention. The method includes the steps of forming a mixture from a predetermined amount of the first component with a predetermined amount of the second component, heating the mixture to melt at least one of the components, and mixing the components to form an eutectic blend. In a preferred embodiment, the method further includes the step of cooling the eutectic blend.

Abstract: Compounds and compositions are disclosed for increasing the bioavailability of lipophilic drugs, and more specifically, to solubilizing lipophilic drugs using bioenhancers that cause no efflux inhibition or a desired degree of efflux inhibition. Methods of making and using such compositions are also disclosed.

Abstract: A vapor-phase carbonylation method for producing esters and carboxylic acids from reactants comprising lower alkyl alcohols, lower alkyl alcohol generating compounds, and mixtures thereof. The method includes contacting the reactants and carbon monoxide in a carbonylation zone of a carbonylation reactor under vapor-phase conditions with a catalyst having a catalytically effective amount of iridium and tin associated with a solid carrier material.

Abstract: A vapor-phase carbonylation method for producing esters and carboxylic acids from reactants comprising lower alkyl alcohols, lower alkyl alcohol generating compounds, and mixtures thereof. The method includes contacting the reactants and carbon monoxide in a carbonylation zone of a carbonylation reactor under vapor-phase carbonylation conditions with a catalyst having a catalytically effective amount of a Group VIII metal selected from platinum or palladium, and tungsten which are associated with a solid catalyst support material.

Abstract: A solid carbonylation catalyst useful for producing esters and carboxylic acids from reactants including lower alkyl alcohols and lower alkyl alcohol producing compositions in a vapor phase carbonylation process wherein the catalyst includes a catalytically effective amount of a Group VIII metal selected from platinum or palladium, and tungsten which are associated with a solid catalyst support material.

Abstract: A carbonylation catalyst useful for producing esters and carboxylic acids from reactants including lower alkyl alcohols, lower alkyl alcohol generating compounds, such as ether and ester derivatives of the alcohols, and mixtures thereof in a vapor phase carbonylation process. The catalyst includes a solid component having a catalytically effective amount of iridium and tin which are associated with a solid catalyst support material and a vaporous halide component.

Abstract: A carbonylation catalyst useful for producing esters and carboxylic acids from reactants including lower alkyl alcohols, lower alkyl alcohol generating compositions such as ether and ester derivatives of the alcohols, and mixtures thereof in a vapor phase carbonylation process, said catalyst includes a solid component having a catalytically effective amount of platinum and tin associated with a solid catalyst support material and a vaporous halide promoter component.