Abstract: A system is provided for classifying an instruction sequence with a machine learning model. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one processor. The operations may include: processing an instruction sequence with a trained machine learning model configured to detect one or more interdependencies amongst a plurality of tokens in the instruction sequence and determine a classification for the instruction sequence based on the one or more interdependencies amongst the plurality of tokens; and providing, as an output, the classification of the instruction sequence. Related methods and articles of manufacture, including computer program products, are also provided.

Abstract: A system for electrical stimulation of the salivary glands for the treatment of dry mouth is disclosed. In one embodiment, the system includes a headset with an electronic control module, placed on the back head, and a stimulating module, placed on the area to be stimulated. Both modules are connected by an elastic arm. The stimulating module provides one or more pairs of electrodes in contact with neuro-sensitive areas of a patient, and is anchored in the ear canal. The position of the electrodes is adjustable for optimized stimulation. The system may be operated by control bottoms that are part of the electronic control module or by a mobile device, such as a wireless remote control, a smartphone, or a tablet. A mobile device camera may be used for correcting the placement of the electrodes.

Abstract: Embodiments of the invention provide a reusable intra-oral device for treating xerostomia. The device having a structure adaptable for oral cavities of multiple users. The hermitically sealed housing comprises of an electronic module having a signal generator configured to generate electrical signals based on one or more values of one or more predefined parameters. Further, the device comprises of electrodes connected to the electronic module. The electrodes are configured to apply the electric signals for stimulating lingual nerves in the oral cavities to induce salivation.

Abstract: A monitoring system embodying a monitoring system embodying a method of this invention for monitoring predetermined patients with mental and/or behavioral disorders by accessing, analyzing and monitoring their measured input through a plurality of sensors inherent in most personal mobile devices is provided. The measured input may represents values attributed to at least one physical behavior of the patient that is representative of a symptom of at least one mental/behavior health condition. The measured input can be used to establish a baseline and thresholds thereof that separates the at least one physical behavior into normative from ab-normative behavior for each predetermined patient.

Abstract: Described is a process for producing aqueous solutions of vinyllactam polymers and solids obtainable therefrom by drying, especially polyvinylpyrrolidone, said process comprising using one or more sulfur components selected from the group consisting of sulfur dioxide, sulfurous acid and one or more salts of sulfurous acid, to reduce residual monomer. Also described are vinyllactam polymers obtainable by the process which have good stability in storage, the use of these vinyllactam polymers, and articles of manufacture and preparations comprising these vinyllactam polymers or obtained by use thereof.

Abstract: Embodiments of the invention disclose a system for controlled oral drug delivery. The system comprising a removable device comprising a drug to be delivered, wherein the drug is delivered based on osmotic pressure generated in the removable device. Further, the system comprises a receptacle to hold the removable device in an oral cavity, and a base station configured to dock the removable device for determining information about one or more characteristics of the removable device.

Abstract: Described is a process for producing aqueous solutions of vinyllactam polymers and solids obtainable therefrom by drying, especially polyvinylpyrrolidone, said process comprising using one or more sulfur components selected from the group consisting of sulfur dioxide, sulfurous acid and one or more salts of sulfurous acid, to reduce residual monomer. Also described are vinyllactam polymers obtainable by the process which have good stability in storage, the use of these vinyllactam polymers, and articles of manufacture and preparations comprising these vinyllactam polymers or obtained by use thereof.

Abstract: Embodiments of the invention disclose a system for controlled oral drug delivery. The system comprising a removable device comprising a drug to be delivered, wherein the drug is delivered based on osmotic pressure generated in the removable device. Further, the system comprises a receptacle to hold the removable device in an oral cavity, and a base station configured to dock the removable device for determining information about one or more characteristics of the removable device.

Abstract: Embodiments of the invention provide a portable dental whitening device. The device comprises a flexible mouthpiece including a bite platform having a horseshoe shape adapted to receive a plurality of mouth shapes. The mouthpiece comprising at least one lighting element for generating light, at least one heating element for generating heat, a flexible printed circuit board, and at least one temperature sensor for detecting the temperature of the heat generated by the at least one heating elements. Further, the device comprises a control unit for selectively powering said lighting element and said heating element. The dental whitening is achieved by applying simultaneously the light and the heat and the chemical activity delivered by a whitening agent provided in the mouthpiece.

Abstract: Embodiments of the invention provide a reusable intra-oral device for treating xerostomia. The device having a structure adaptable for oral cavities of multiple users. The hermitically sealed housing comprises of an electronic module having a signal generator configured to generate electrical signals based on one or more values of one or more predefined parameters. Further, the device comprises of electrodes connected to the electronic module. The electrodes are configured to apply the electric signals for stimulating lingual nerves in the oral cavities to induce salivation.

Abstract: The invention is directed to manufacturing and testing methods of electronic intraoral devices for diagnose, monitor and treat local and systemic diseases and conditions for humans and animals. More specifically, the current invention deals with manufacturing techniques, testing methods and a testing apparatus of mainly three types of intra-oral devices: (a) electro-stimulators for various applications such as treatment of dry mouth by stimulating saliva secretion, apnea, sleeping disorders, eating disorders (obesity, anorexia, etc.) dysphagia and others, (b) drug delivery devices; and (c) bio-sensing and monitoring devices. The common parts or the devices are: (1) art electronic module embedded in the device: (2) or a power source being embedded in the device; (3) the devices (or part of them) being placed in the oral cavity.

Abstract: Controlled-specimen-sampling oral devices are described, implanted or inserted into an oral cavity, built onto a prosthetic tooth crown, a denture plate, braces, a dental implant, or the like. The devices are replaced as needed. The controlled specimen sampling may be passive, based on a dosage form, or electro-mechanically controlled, for a high-precision, intelligent, specimen sampling. Additionally, the controlled sampling may be any one of the following: sampling in accordance with a preprogrammed regimen, sampling at a controlled rate, delayed sampling, pulsatile sampling, chronotherapeutic sampling, closed-loop sampling, responsive to a sensor's input, sampling on demand from a personal extracorporeal system, sampling regimen specified by a personal extracorporeal system, sampling on demand from a monitoring center, via a personal extracorporeal system, and sampling regimen specified by a monitoring center, via a personal extracorporeal system.

Abstract: Drug dosage forms, which are housed in oral devices, and methods for controlled drug release are provided. The oral devices are permanently or removably inserted in the oral cavity and refilled or replaced as needed. The controlled drug release may be passive, based on the dosage form, or electronically controlled, for a high-precision, intelligent, drug delivery. Additionally, the controlled release may be any one of the following: release in accordance with a preprogrammed schedule, release at a controlled rate, delayed release, pulsatile release, chronotherapeutic release, closed-loop release, responsive to a sensor's input, release on demand from a personal extracorporeal system, release in accordance with a schedule specified by a personal extracorporeal system, release on demand from a monitoring center, via a personal extracorporeal system, and release in accordance with a schedule specified by a monitoring center, via a personal extracorporeal system.

Abstract: An implantable device for inducing salivation by neural stimulation at neurally sensitive location within an oral or perioral tissue of a user. The device includes a housing adapted to be permanently implanted within the oral or perioral tissue. The housing has an enclosure therein for engaging an electrical signal generator. The signal generator includes a power source and at least one electrode operatively associated with the housing and electrically coupled to the signal generator. The electrode is so positioned with respect to the housing so as to form an electrical contact with the oral or perioral tissue and in operative contact with a neurally sensitive location of the oral or perioral tissue, the stimulation of which by electrical energy can induce salivation when the housing is operatively disposed, whereby the electrode applies a signal generated by the signal generator to the sensitive location of the oral or perioral tissue to induce salivation.

Abstract: A fluid sampling device for sampling and collecting biological fluids from membrane bounded areas of a subject includes a buffering chamber to which a vacuum is applied, a sampling tube connector, a storage tube connector and a vent. In operation the vent is closed to apply the vacuum to a sampling tube connected to the sample tube connector to draw a sample into the buffering chamber. The drawn fluid flows under gravitational force into a storage tube attached to the storage tube connector. The device is particularly useful for sampling and collecting submandibular and sublingual saliva.