Patents by Inventor Aneta BAJ

Aneta BAJ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of MK-7 type of vitamin K2
    Patent number: 9828323
    Abstract: Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of “all-trans” configuration to monoprenyl derivative of menadiol following “1+6” synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z? and Z? represent H or one of Z? and Z? represents H and the other represents phenylsulfonyl group —SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: November 28, 2017
    Assignee: Nattopharma R & D Ltd.
    Inventors: Krzysztof Krajewski, Andrzej Kutner, Jadwiga Dzikowska, Regina Gutowska, Marek Napiórkowski, Jerzy Winiarski, Marek Kubiszewski, Łukasz Jedynak, Jacek Morzycki, Stanislaw Witkowski, Aneta Baj, Piotr Wałejko
  • PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2
    Publication number: 20150291498
    Abstract: Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of “all-trans” configuration to monoprenyl derivative of menadiol following “1+6” synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z? and Z? represent H or one of Z? and Z? represents H and the other represents phenylsulfonyl group —SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 15, 2015
    Applicant: NATTOPHARMA R&D LTD
    Inventors: Krzysztof KRAJEWSKI, Andrzej KUTNER, Jadwiga DZIKOWSKA, Regina GUTOWSKA, Marek NAPIÓRKOWSKI, Jerzy WINIARSKI, Marek KUBISZEWSKI, Lukasz JEDYNAK, Jacek MORZYCKI, Stanislaw WITKOWSKI, Aneta BAJ, Piotr WALEJKO