Patents by Inventor Anette Graven Sams

Anette Graven Sams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Positive allosteric modulators of nicotinic acetylcholine receptor
    Publication number: 20140323523
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 30, 2014
    Inventors: Anette Graven Sams, Jørgen Eskildsen, Ask Puschl
  • Positive allosteric modulators of nicotinic acetylcholine receptor
    Patent number: 8815914
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: August 26, 2014
    Assignee: H. Lundbeck A/S
    Inventors: Anette Graven Sams, Jorgen Eskildsen, Ask Püschl
  • Positive allosteric modulators of nicotinic acetylcholine receptor
    Patent number: 8765790
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: July 1, 2014
    Assignee: H. Lundbeck A/S
    Inventors: Jørgen Eskildsen, Anette Graven Sams, Ask Püschl
  • NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR
    Publication number: 20140044806
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: October 16, 2013
    Publication date: February 13, 2014
    Applicant: H. Lundbeck A/S
    Inventors: Jørgen Eskildsen, Anette Graven Sams, Ask Püschl
  • New positive allosteric modulators of nicotinic acetylcholine receptor
    Publication number: 20140010897
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 9, 2014
    Inventors: Anette Graven Sams, Jorgen Eskildsen, Ask Püschl
  • New positive allosteric modulators of nicotinic acetylcholine receptor
    Publication number: 20140010898
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 9, 2014
    Inventors: Jorgen Eskildsen, Anette Graven Sams, Ask Püschl
  • Positive allosteric modulators of nicotinic acetylcholine receptor
    Patent number: 8598213
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: December 3, 2013
    Assignee: H. Lundbeck A/S
    Inventors: Jørgen Eskildsen, Anette Graven Sams, Ask Püschl
  • 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME
    Publication number: 20130231321
    Abstract: The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R1, R2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods of using same.
    Type: Application
    Filed: April 16, 2013
    Publication date: September 5, 2013
    Applicant: H. LUNDBECK A/S
    Inventors: Mathivanan Packiarajan, Allen Hopper, Anette Graven Sams, Gitte Kobberoee Mikkelsen, Michel Grenon
  • NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF
    Publication number: 20130172325
    Abstract: The invention relates to compounds of general formula (I) wherein R1, R2, R3, R4, m and n are defined as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immuno-suppression would be desirable for example in organ transplantation.
    Type: Application
    Filed: July 8, 2011
    Publication date: July 4, 2013
    Applicant: LEO PHARMA A/S
    Inventors: Simon Felbdæk Nielsen, Daniel R. Greve, Gunnar Grue-Sorensen, Carsten Ryttersgaard, Søren Christian Schou, Anette Graven Sams
  • 2-substituted-ethynylthiazole derivatives and uses of same
    Patent number: 8440837
    Abstract: The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R1, R2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods of using same.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: May 14, 2013
    Assignee: H. Lundbeck A/S
    Inventors: Allen Hopper, Anette Graven Sams, Gitte Kobberoee Mikkelsen, Mathivanan Packiarajan, Michel Grenon
  • New Positive allosteric modulators of nicotinic acetylcholine receptor
    Publication number: 20130012530
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 10, 2013
    Applicant: H. Lundbeck A/S
    Inventors: Jørgen Eskildsen, Anette Graven Sams, Ask Püschl
  • Positive allosteric modulators of nicotinic acetylcholine receptor
    Publication number: 20120252853
    Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.
    Type: Application
    Filed: March 30, 2012
    Publication date: October 4, 2012
    Applicant: H. Lundbeck A/S
    Inventors: Anette Graven Sams, Jørgen Eskildsen, Jesper Frank Bastlund
  • 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME
    Publication number: 20110092475
    Abstract: The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R1, R2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods of using same.
    Type: Application
    Filed: October 20, 2010
    Publication date: April 21, 2011
    Applicant: H. LUNDBECK A/S
    Inventors: Allen Hopper, Anette Graven Sams, Gitte Kobberoee Mikkelsen, Mathivanan Packiarajan, Michel Grenon
  • Pro-drugs of -thiazol-2-yl-benzamide derivatives
    Patent number: 7674912
    Abstract: The invention relates to compounds of the formula I A-B-Z ??I wherein the variables are as defined in the claims. The compounds are pro-drugs of A2A-receptor ligands with improved aqueous solubility, and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: March 9, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Anette Graven Sams, Benny Bang-Andersen, Gitte Mikkelsen, Mogens Larsen
  • N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES
    Publication number: 20090247593
    Abstract: The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are A2A-receptor ligands, such as antagonists, agonists, reverse agonists or partial agonists, and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.
    Type: Application
    Filed: December 19, 2008
    Publication date: October 1, 2009
    Applicant: H. Lundbeck A/S
    Inventors: Anette Graven Sams, Mogens Larsen, Gitte Mikkelsen
  • 2-Acylaminothiazole Derivatives
    Publication number: 20090137642
    Abstract: The Invention relates to compounds of the formula I, wherein the variables are as defined in the claims, for use as a medicament. The compounds are A2A-receptor legends and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.
    Type: Application
    Filed: September 20, 2005
    Publication date: May 28, 2009
    Applicant: H. LUNDBECK A/S
    Inventors: Mogens Larsen, Anette Graven Sams, Gitte Mikkelsen, Benny Bang-Andersen