Patents by Inventor .ANG.ke Silen

.ANG.ke Silen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using monoclonal antibodies to cytokeratin fragments
    Patent number: 5780032
    Abstract: Provided is a method for reproducible production of cytokeratin antigen/immunogen. Cytokeratins from whole carcinoma cells are purified by preparative SDS-PAGE. Bands corresponding to cytokeratins 8, 18, and 19 are eluted from the gel, and these cytokeratins are digested to produce fragments in the size range of 10-50 Kd. The invention also relates to use of these fragments as immunogens for the production of antibodies. Furthermore, the invention relates to an immunochemical test kit to detect cancer of epithelial origin in body fluids. The kit comprises cytokeratin fragments produced by the method of the invention and antibodies to these fragments.
    Type: Grant
    Filed: June 19, 1996
    Date of Patent: July 14, 1998
    Assignee: AB IDL Immunodevelop Lab
    Inventors: .ANG.ke Silen, Bo Wiklund
  • Methods of producing antibodies against cytokeraton fragments and test kits containing such fragments
    Patent number: 5728537
    Abstract: Provided is a method for reproducible production of cytokeratin antigen immunogen. Cytokeratins from whole carcinoma cells are purified by preparative SDS-PAGE. Bands corresponding to cytokeratins 8, 18, and 19 are eluted from the gel, and these cytokeratins are digested to produce fragments in the size range of 10-50 Kd. The invention also relates to use of these fragments as immunogens for the production of antibodies. Furthermore, the invention relates to an immunochemical test kit to detect cancer of epithelial origin in body fluids. The kit comprises cytokeratin fragments produced by the method of the invention and antibodies to these fragments.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: March 17, 1998
    Assignee: AB IDL Immunodeveloplab
    Inventors: .ANG.ke Silen, Bo Wiklund