Abstract: A method of manufacturing a sensor for in vivo applications includes the steps of providing two wafers of an electrically insulating material. A recess is formed in the first wafer, and a capacitor plate is formed in the recess of the first wafer. A second capacitor plate is formed in a corresponding region of the second wafer, and the two wafers are affixed to one another such that the first and second capacitor plates are arranged in parallel, spaced-apart relation.

Abstract: A system, apparatus, and method for processing a sample for chemical and/or biological analysis, and detecting one or more target substances. A first system of microfabricated components includes at least a reservoir and a channel, and a second system of detection components including at least a lens. The lens is focused on a sensing platform of the first system. The sensing platform is coupled to the reservoir by the channel. Various types of detection systems can be utilized with the present invention including fluorescence detection systems with a laser that is positioned to illuminate a sample in the sensing platform. The microfabricated components include one or more pumps, valves, mixers, and filters. A thermoelectric cooler can be positioned to control the temperature of at least one of the microfabricated components. A variety of component configurations can be implemented, and a variety of different processes can be performed, depending on the configuration of components.

Abstract: A system, apparatus, and method for processing a sample for chemical and/or biological analysis, and detecting one or more target substances. A first system of microfabricated components includes at least a reservoir and a channel, and a second system of detection components including at least a lens. The lens is focused on a sensing platform of the first system. The sensing platform is coupled to the reservoir by the channel. Various types of detection systems can be utilized with the present invention including fluorescence detection systems with a laser that is positioned to illuminate a sample in the sensing platform. The microfabricated components include one or more pumps, valves, mixers, and filters. A thermoelectric cooler can be positioned to control the temperature of at least one of the microfabricated components. A variety of component configurations can be implemented, and a variety of different processes can be performed, depending on the configuration of components.

Abstract: The present invention is a microfabricated system for performing biochemical analysis on a test sample of substance. The system includes a substrate with a sample entry port, one or more pump chambers, and one or more mixers. Channels are connected between the pump chambers and the mixers to conduct the flow of the substance during the processing. A magnetic member is positioned on a diaphragm over each pump chamber, creating a pump that is actuated by attracting and repelling the magnetic member with a magnet. Each magnetic member is attracted or repelled independently of the other magnetic members.

Abstract: A microfluidic pump having a substrate with a pump chamber and at least one channel in communication with the pump chamber for transporting a substance into or out of the pump chamber. A flexible diaphragm overlies the pump chamber, and a magnetic member is attached to the diaphragm. A magnet, such as an electromagnet, is positioned to attract and repel the magnetic member, thereby actuating the diaphragm, and causing a substance to be drawn into or out of the channel. A uni-directional or bi-directional check valve can be positioned in the channel to prevent backflow into the pump chamber. A control system can be coupled to the pump to adjust actuation rate of the diaphragm.