Patents by Inventor Angel Alvarez
Angel Alvarez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240068277Abstract: A vehicle latch, including: a power release mechanism for transitioning the vehicle latch from a latched state to an unlatched state, the power release mechanism includes a motor that rotates a worm that meshingly engages a power release gear, which is operably coupled to a pawl of the latch; and a spring provided to reduce a speed of the gear as it is back driven into a home position.Type: ApplicationFiled: August 29, 2022Publication date: February 29, 2024Inventors: Hector Sanchez Rojas, Pedro Alfredo Alvarado Heredia, Jesus Osvaldo Alvarez Morales, Miguel Angel Baray Gonzalez, Victor Daniel Varela Antillon
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Publication number: 20200246334Abstract: Disclosed herein are methods for increasing the overall vigor of a subject, and/or vigor of target tissues of a subject. Exemplified herein is the utilization of pyrimidine derivatives which act to stimulate stem cell proliferation. In addition to increasing vigor, such stem cell proliferation agents (SCPA) may be used to enhance and/or improve the outcome of other therapies, and may be used in psychiatric applications. Increasing vigor in subjects is not necessarily targeted to the treatment of a disease, thus, the methods can include administration to clinically healthy animals.Type: ApplicationFiled: April 22, 2020Publication date: August 6, 2020Inventors: Kiminobu SUGAYA, Angel ALVAREZ
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Publication number: 20200061260Abstract: The present invention relates to a device and method for the preparation of platelet rich plasma, and to the plasma obtained by employing said device and method. The method comprises evaporating and dialysing plasma with the device of the invention to provide a plasma enriched in platelets and non-platelet biomolecules. The plasma thus obtained shows improved regenerative properties with respect to other plasma preparations.Type: ApplicationFiled: May 11, 2018Publication date: February 27, 2020Inventors: Ramon Angel Alvarez-Puebla, Sara Gomez de Pedro, Manuel Garcia Algar, Moritz Julian Nazarenus, Xiaotong Feng, Mikel Sanchez Alvarez, Pello Sanchez Arizmendiarrieta, Diego Delgado San Vicente, Ane Garate Letona, Julian Alonso Chamarro, Maria del Mar Puyol Bosch, Antonio Calvo Lopez
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Publication number: 20200055048Abstract: The present invention relates to a microfluidic device for the detection of circulating tumour cells (CTCs) in a fluid sample. The invention also relates to an in vitro method for the detection and/or quantification of circulating tumour cells (CTCs) in a fluid sample. Further, the invention relates to in vitro methods for (a) diagnosing a tumour and/or metastasis in a subject, and (b) determining the prognosis of a subject suffering from a tumour and/or metastasis. Finally, the invention refers to a kit comprising (a) a microfluidic device according to the first aspect of the invention, and (b) labelled probes targeting a first CTCs surface marker and, optionally, at least a second CTCs surface marker.Type: ApplicationFiled: April 9, 2018Publication date: February 20, 2020Inventors: Ramon Angel Alvarez-Puebla, Eric Pedrol, Jaume Massons, Francisco Diaz, Manuel Garcia Algar, Moritz Julian Nazarenus, Eduardo Garcia-Rico Fernandez
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Publication number: 20190167674Abstract: Disclosed herein are methods for increasing the overall vigor of a subject, and/or vigor of target tissues of a subject. Exemplified herein is the utilization of pyrimidine derivatives which act to stimulate stem cell proliferation. In addition to increasing vigor, such stem cell proliferation agents (SCPA) may be used to enhance and/or improve the outcome of other therapies, and may be used in psychiatric applications. Increasing vigor in subjects is not necessarily targeted to the treatment of a disease, thus, the methods can include administration to clinically healthy animals.Type: ApplicationFiled: February 6, 2019Publication date: June 6, 2019Inventors: Kiminobu SUGAYA, Angel ALVAREZ
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Patent number: 10266181Abstract: A vehicle control system to mitigate adverse effects relating to the performance and stability of a vehicle that experienced a tire blowout includes a computer programmed to determine a type of tire blowout based at least on a location of the tire blowout and a steering angle at the time of tire blowout, and based at least on the type of tire blowout, to limit at least one of a powertrain and a braking of a vehicle.Type: GrantFiled: December 14, 2016Date of Patent: April 23, 2019Assignee: FORD GLOBAL TECHNOLOGIES, LLCInventors: Angel Alvarez Jaime, Zaid Moises Morales Martinez
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Publication number: 20180162411Abstract: A vehicle control system to mitigate adverse effects relating to the performance and stability of a vehicle that experienced a tire blowout includes a computer programmed to determine a type of tire blowout based at least on a location of the tire blowout and a steering angle at the time of tire blowout, and based at least on the type of tire blowout, to limit at least one of a powertrain and a braking of a vehicle.Type: ApplicationFiled: December 14, 2016Publication date: June 14, 2018Applicant: Ford Global Technologies, LLCInventors: Angel Alvarez Jaime, Zaid Moises Morales Martinez
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Publication number: 20180092913Abstract: Disclosed herein are methods for increasing the overall vigor of a subject, and/or vigor of target tissues of a subject. Exemplified herein is the utilization of pyrimidine derivatives which act to stimulate stem cell proliferation. In addition to increasing vigor, such stem cell proliferation agents (SCPA) may be used to enhance and/or improve the outcome of other therapies, and may be used in psychiatric applications. Increasing vigor in subjects is not necessarily targeted to the treatment of a disease, thus, the methods can include administration to clinically healthy animals.Type: ApplicationFiled: October 6, 2017Publication date: April 5, 2018Inventors: Kiminobu SUGAYA, Angel ALVAREZ
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Publication number: 20170335376Abstract: The invention relates to an aggregate comprising metallic nanoparticles and nucleic acid molecules wherein each metallic nanoparticle is coated with a polycation. The invention also relates to a method for obtaining the aggregate of the invention and to the use of said aggregate in methods for detecting the presence of a nucleic acid in a sample, in methods for detecting the presence of a given nucleotide at a predetermined position in a target nucleic acid, in methods for detecting the presence of a modified nucleotide at a predetermined position in a target nucleic acid, methods for detecting the presence of a conjugate between a double stranded nucleic acid and a chemical in a sample comprising double stranded nucleic acid molecules, in methods for determining the content of modified nucleotides in a target nucleic acid and in a method for determining the content of modified nucleotides in a target nucleic acid.Type: ApplicationFiled: October 23, 2015Publication date: November 23, 2017Inventors: Ramón Ángel Álvarez Puebla, Luca Guerrini, Juan Sagalés Mañas, Duncan Graham
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Publication number: 20170196918Abstract: The invention relates to a bacterial strain, Lactobacillus casei IPLA12038 with deposit number CECT 8590, and its use for the degradation of gluten, gliadin or derivative peptides. The strain has been isolated from an acidic dough used to make bread. Its advantages include the ability to use gliadin as nitrogen source, possess peptidase activities involved in the degradation of it and be able to completely degrade the immunotoxic (33) amino acid peptide involved in triggering of celiac disease in a short period of time. The fact of considering it a GRAS and QPS microorganism, isolated from a fermented food, sensitive to antimicrobial gastrointestinal agents and resistant to gastrointestinal conditions tested in vitro, guarantees its use as a probiotic or nutraceutical supplement.Type: ApplicationFiled: May 22, 2015Publication date: July 13, 2017Inventors: Patricia Alvarez Sieiro, Maria Cruz Martin Martin, Begona Redruello Trelles, Victor Ladero Losada, Maria Fernandez Garcia, Miguel Angel Alvarez Gonzalez
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Publication number: 20170189550Abstract: A silicon particle comprising a silicon body, a functionalized silica surface surrounding the silicon body, and a targeting moiety specifically targeting tumor cells, and, optionally, an enzymatically metabolizable compound, is useful in the treatment of cancer by producing cell death after particle internalization.Type: ApplicationFiled: May 22, 2015Publication date: July 6, 2017Inventors: Ramón Ángel Álvarez Puebla, Roberto Fenollosa Esteve, Francisco Javier Messeguer Rico, Marie Isabelle Rodríguez, Susana Álvarez Rodríguez, Rosana Álvarez Rodríguez, Ángel Rodríguez De Lera, Eduardo García-Rico Fernández, Xiang Yu, Susana Carregal Romero, Wolfgang Johann Parak, Carlos Villanueva Leal, Pilar Rivera Gil
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Patent number: 9656374Abstract: An automotive assembly line tool system and method utilizing a heat-shrinkable bumper disposed around a portion of an assembly line tool for absorbing kinetic energy between the portion of the tool and a work-piece on an assembly line. The bumper may be a chemically cross-linked polyolefin heat-shrinkable material having a shore D hardness of 42 or less after being heat-shrunk. The bumper may be a tubular bumper that has a continuous outer surface around its circumference and a heavy wall that is highly split-resistant. The bumper may have a life term of at least one year in an automotive assembly line environment. By protecting the tools and equipment, chips and scratches on a work-piece on the assembly line may be reduced.Type: GrantFiled: January 16, 2014Date of Patent: May 23, 2017Assignee: Ford Global Technologies, LLCInventors: Jocelyn Moctezuma, Zoram Florencio, Angel Alvarez
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Patent number: 9556069Abstract: Certain example embodiments of this invention relate to sputtered aluminum second surface mirrors with permanent protective coatings optionally provided thereto, and/or methods of making the same. A mirror coating supported by a substrate may include, for example, first and second silicon-inclusive layers sandwiching a metallic or substantially metallic layer including aluminum, and an optional layer including Ni and/or Cr in direct contact with the metallic or substantially metallic layer comprising aluminum. A protective paint is disposed directly over and contacting an outermost layer of the mirror coating. The protective paint, once applied and cured, is adapted to survive seven day exposure to an 85 degree C. temperature at 85% relative humidity, as well as seven day exposure to a 49 degree C. temperature at 100% relative humidity.Type: GrantFiled: April 30, 2013Date of Patent: January 31, 2017Assignee: Centre Luxembourgeois de Recherches pour le Verre et la Ceramique (C.R.V.C.) SaRLInventors: Guillermo Benito Gutierrez, Javier Unquera Algorri, Angel Alvarez Rodriguez
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Patent number: 9506031Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.Type: GrantFiled: December 8, 2014Date of Patent: November 29, 2016Assignee: University of Central Florida Research Foundation, Inc.Inventors: Kiminobu Sugaya, Angel Alvarez
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Patent number: 9243226Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells or mesenchymal stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.Type: GrantFiled: February 25, 2008Date of Patent: January 26, 2016Assignee: University of Central Florida Research Foundation, Inc.Inventors: Kiminobu Sugaya, Angel Alvarez
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Patent number: 9127291Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.Type: GrantFiled: August 19, 2013Date of Patent: September 8, 2015Assignee: University of Central Florida Research Foundation, Inc.Inventors: Kiminobu Sugaya, Angel Alvarez, Amelia Marutle
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Publication number: 20150198210Abstract: An automotive assembly line tool system and method utilizing a heat-shrinkable bumper disposed around a portion of an assembly line tool for absorbing kinetic energy between the portion of the tool and a work-piece on an assembly line. The bumper may be a chemically cross-linked polyolefin heat-shrinkable material having a shore D hardness of 42 or less after being heat-shrunk. The bumper may be a tubular bumper that has a continuous outer surface around its circumference and a heavy wall that is highly split-resistant. The bumper may have a life term of at least one year in an automotive assembly line environment. By protecting the tools and equipment, chips and scratches on a work-piece on the assembly line may be reduced.Type: ApplicationFiled: January 16, 2014Publication date: July 16, 2015Applicant: FORD GLOBAL TECHNOLOGIES, LLCInventors: Jocelyn Moctezuma, Zoram Florencio, Angel Alvarez
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Publication number: 20150147813Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.Type: ApplicationFiled: December 8, 2014Publication date: May 28, 2015Applicant: University of Central Florida Research Foundation, Inc.Inventors: Kiminobu Sugaya, Angel Alvarez
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Publication number: 20150056704Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.Type: ApplicationFiled: August 19, 2013Publication date: February 26, 2015Applicant: University of Central Florida Research Foundation, Inc.Inventors: Kiminobu Sugaya, Angel Alvarez, Amelia Marutle
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Patent number: 8906683Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.Type: GrantFiled: May 30, 2012Date of Patent: December 9, 2014Assignee: University of Central Florida Research Foundation, Inc.Inventors: Kiminobu Sugaya, Angel Alvarez