Abstract: The invention relates to a diffractive device for chemical and biological analysis based on structured receptors on waveguides, which comprises: a waveguide and a recognition element consisting of a grating with receptors arranged on the waveguide and are intended to interact with target compounds present in a sample; and a radiation source that emits an incident beam propagated through the waveguide, interacting with the recognition element and being diffracted according to Bragg's law, thereby generating a reflected beam and a transmitted beam, which are collected by optical analyzers that record parameters of the reflected beam and of the transmitted beam, enabling multiple analyses to be conducted in a simple, fast, 15 sensitive and quantitative manner, label-free and in real time.

Abstract: A method for the diagnosis of systemic lupus erythematosus (SLE) based on an interfacial process of antigen-antibody molecular recognition, specifically between anti-Ro52 and Ro52 protein, in a piezoelectric resonator, for application in the diagnosis of autoimmune diseases such as SLE.

Abstract: The invention relates to a diffractive device (18) for chemical and biological analysis based on structured receptors on waveguides, which comprises: a waveguide (1) and a recognition element (3) consisting of a grating with receptors (11) arranged on the waveguide (1) and are intended to interact with target compounds (12) present in a sample; and a radiation source (4) that emits an incident beam (5) propagated through the waveguide (1), interacting with the recognition element (3) and being diffracted according to Bragg's law, thereby generating a reflected beam (6) and a transmitted beam (7), which are collected by optical analysers (8, 17) that record parameters of the reflected beam (6) and of the transmitted beam (7), enabling multiple analyses to be conducted in a simple, fast, sensitive and quantitative manner, label-free and in real time.

Abstract: The present invention relates to a method for the diagnosis of systemic lupus erythematosus (SLE), which is a diagnostic method based on an interfacial process of antigen-antibody molecular recognition, specifically between anti-Ro52 and Ro52 protein, in a piezoelectric resonator, for application in the diagnosis of autoimmune diseases such as SLE.

Abstract: The method comprises chemical modification of an optionally metallized polymer surface, for example a polycarbonate surface or a polymethacryllate surface functionalized with amino groups, said surfaces being optionally metallized, by treating said polymer surface with a mercaptoalkanoic acid or the salts or derivates thereof. The surfaces obtained by said method may be used as solid supports for immobilizing biomolecules, such as nucleic acids, proteins or membranes.

Abstract: The method comprises chemical modification of an optionally metallized polymer surface, for example a polycarbonate surface or a polymethacryllate surface functionalized with amino groups, said surfaces being optionally metallized, by treating said polymer surface with a mercaptoalkanoic acid or the salts or derivates thereof. The surfaces obtained by said method may be used as solid supports for immobilizing biomolecules, such as nucleic acids, proteins or membranes.