Abstract: Method for generating and controlling complex strain patterns on biological materials comprising the steps of providing a magnetic stimulation device and a magneto-responsive substrate; culturing biological material in the substrate; determining the position of the magnetic stimulation device for obtaining a defined strain pattern on the biological material; placing the magnets in the position determined; and activating a magnetic stimulation device to generate a complex strain pattern in the magneto-responsive substrate and consequently in the biological material; and magneto-mechanical stimulation system comprising a magneto-responsive substrate configured to hold biological material; a holder for placing the magneto-responsive substrate; a magnetic stimulation device configured to generate a complex strain pattern on the biological material by generating a magnetic field which acts over the magneto-responsive substrate; a computing module; an imaging module for long-term monitoring; and an interface module

Abstract: This disclosure relates to a computer-implemented method, a mobile device, and a computer readable storage medium, for displaying a medical value such as, e.g., a glucose value, on a screen of a mobile device.

Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.

Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.

Abstract: The invention relates to a method for obtaining membrane vesicles enriched in membrane transport proteins of plant origin, for cosmetic or therapeutic use, which can contain other substances, such as natural bioactive compounds. Preferably, said vesicles are obtained from plants of the Brassicaceae (cruciferae) family. In addition, the invention relates to a method for increasing these proteins of plant origin.

Abstract: The invention relates to a method for obtaining membrane vesicles enriched in membrane transport proteins of plant origin, for cosmetic or therapeutic use, which can contain other substances, such as natural bioactive compounds. Preferably, said vesicles are obtained from plants of the Brassicaceae (cruciferae) family. In addition, the invention relates to a method for increasing these proteins of plant origin.

Abstract: The invention relates to novel expression systems for microRNAs (miRNAs) based on the expression of the sense and antisense strand from convergent promoters. The invention also provides a method for the direct cloning of small RNAs present in an RNA preparation by the direct ligation of the small RNAs present within the preparation to vectors. Interestingly, if the vectors contain convergent promoter regions, the vectors isolated according to the method of the invention can be used for the direct expression of the small RNA without the need of using the DNA encoding for the small RNA precursor molecule.

Abstract: The invention relates to a method for determining an indicator of the stresses to which a construction vehicle fire is subjected during a given period in which the product of the load transported by the vehicle and the distance traveled by the vehicle during the period is adjusted by an adjustment factor based on use parameters of the vehicle.

Abstract: A system and method for allocating the nearest available physical memory in a distributed, shared memory system. In various embodiments, a processor node may broadcast a memory request to a first subset of nodes connected to it via a communication network. In some embodiments, if none of these nodes is able to satisfy the request, the processor node may broadcast the request to additional subsets of nodes. In some embodiments, each node of the first subset of nodes may be removed from the processor node by one network hop and each node of the additional subsets of nodes may be removed from the processor node by no more than an iteratively increasing number of network hops. In some embodiments, the processor node may send an acknowledgment to one node that can fulfill the request and a negative acknowledgement to other nodes that can fulfill the request.

Abstract: The invention relates to a method for determining an indicator of the stresses to which a construction vehicle fire is subjected during a given period in which the product of the load transported by the vehicle and the distance traveled by the vehicle during the period is adjusted by an adjustment factor based on use parameters of the vehicle.

Abstract: An isolated DNA having the promoter sequence of the hex gene of P. chrysogenum or a DNA fragment that is hybridizable to the complement of the promoter sequence under stringent conditions and is capable of directing expression of DNA downstream of the fragment in P. chrysogenum. Also a process for promoting expression of a coding sequence of interest in a microorganism using the isolated DNA and a process to block expression of a gene of interest in a microorganism using the isolated DNA are disclosed.

Abstract: The invention relates to promoters of the genes glutamate dehydrogenase, &bgr;-acetylhexosaminidase and &ggr;-actin and their use in systems of expression, secretion and anti-sense of filamentary fungi. The invention also relates to the use of the promoters of the genes which code: (I) glutamate dehydrogenase NADP depending (EC.1.4.1.4) of Penicillium chrysogenum, (II) &ggr;-N-actylhexosaminidase (EC.3.2.1.52) of Penicillium chrysogenum and (III) &ggr;-actin of Penicillium chrysogenum and Acrimonium chrysogenum, which can be used for the construction of potent vectors of expression and secretion useful both for P. chrysogenum and for A. chrysogenum and related species. These promoters can also be used for blocking the genic expression through anti-sense construction. Under the control of the above mentioned promoters, it is possible to conduct the expression of other genes in filamentary fungi, thereby increasing the production of antibiotics and/or proteins inherent to the same.

Abstract: An isolated DNA encoding phenyl acetyl-CoA-ligase and a process of increasing the production of penicillin G in a strain of Penicillium chrysogenum by transforming the strain with the isolated DNA. Also vectors and host organisms having the isolated DNA.

Abstract: Process for producing the enzyme D-amino acid oxydase of Rhodotorula gracilis in host cells. The process for the expression of the enzyme comprises isolating the complementary DNA corresponding to the messager RNA of the gene which codes for the D-amino acid oxydase of any strain of Rhodotorula gracillis producing said enzyme; fusing the fragment of DNA which codes for D-amino acid oxydase of Rhodotorula gracillis with a DNA sequence which contains a site of union to the ribosome and a high efficiency promoter sequence for the express of genes in host cells; inserting the DNA fragment into a plasmid appropriate for the host cell; cultivating the host cells transformed with said plasmid; and collecting the enzyme.

Abstract: A batch fermentation is carried out continuously or semicontinuously using strain of Streptomyces clavuligerus for the production of clavulanic acid. The fermentation process is carried out with strict control of the soluble phosphate in the medium both at the beginning and throughout the process.

Abstract: A motor driven by a fluid motion, comprising a rotor with a vane whose surface varies according to the vane position relatively to the fluid flow direction. To create a thrust on the vane when the fluid moves quasi-parallel to the vane longitudinal axis, at least one side-panel is provided on the vane, generally perpendicular to the longitudinal axis thereof.