Patents by Inventor Angel R. De Lera

Angel R. De Lera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRECURSOR COMPOUNDS FOR PROVIDING RETINOIDS OF THE VATAMIN A5 PATHWAY AND USES THEREOF
    Publication number: 20190054056
    Abstract: The invention relates to the field of retinoid X receptor (RXR) signaling and a novel vitamin A pathway called Vitamin A5 pathway. Compounds which are useful to provide (R)-9-cis-13,14-dihydroretinoic acid, an endogenous RXR ligand, are claimed as well as their uses and method for preparation thereof. The compounds of the invention are useful for pharmaceutical and nutritional uses.
    Type: Application
    Filed: August 13, 2018
    Publication date: February 21, 2019
    Inventors: Wojciech KREZEL, Ralph RÜHL, Angel R. DE LERA
  • STEREOSELECTIVE SYNTHESIS OF 9-CIS.13,14-DIHYDRORETINOIC ACID AND ITS ETHYL ESTERS
    Publication number: 20180170867
    Abstract: The retinoid X receptors (RXRs) are ligand-activated transcription factors heterodimerize with a number of nuclear hormone receptors, thereby controlling a variety of physiological processes. The invention relates to novel enantiomer compounds which are derivatives of dihydroretinoic acid, their stereoselective synthesis, to pharmaceutical compositions containing the same and to the use of same in the treatment of diseases.
    Type: Application
    Filed: May 9, 2016
    Publication date: June 21, 2018
    Applicant: University of Debrecen
    Inventors: Wojciech KREZEL, Ralph RÜHL, Angel R. DE LERA
  • Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and in cosmetics
    Publication number: 20030191145
    Abstract: 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: 1
    Type: Application
    Filed: August 9, 2002
    Publication date: October 9, 2003
    Inventors: Angel R. De Lera, Beatriz Dominguez