Patents by Inventor Angela BOROUGHS

Angela BOROUGHS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems targeting PSMA and CA9
    Patent number: 12257304
    Abstract: Provided herein are antibodies and chimeric priming receptors that bind PSMA and antibodies and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.
    Type: Grant
    Filed: March 1, 2024
    Date of Patent: March 25, 2025
    Assignee: Arsenal Biosciences, Inc.
    Inventors: Angela Boroughs, Levi Gray-Rupp, Samuel A. Williams, Zhen Jian Zhou, Matthew Drever, Duy Nguyen, Amy-Jo Casbon, Anzhi Yao, Thomas Gardner
  • SYSTEMS OF ENGINEERED RECEPTORS TARGETING PSMA AND CA9
    Publication number: 20250082682
    Abstract: Provided herein are chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.
    Type: Application
    Filed: November 14, 2024
    Publication date: March 13, 2025
    Inventors: Angela Boroughs, Levi Gray-Rupp, Jamie Thomas, Bryan Smith, Samuel Williams
  • SYSTEMS TARGETING PSMA AND CA9
    Publication number: 20240342284
    Abstract: Provided herein are antibodies and chimeric priming receptors that bind PSMA and antibodies and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.
    Type: Application
    Filed: March 1, 2024
    Publication date: October 17, 2024
    Inventors: Angela Boroughs, Levi Gray-Rupp, Samuel A. Williams, Zhen Jian Zhou, Matthew Drever, Duy Nguyen, Amy-Jo Casbon, Anzhi Yao, Thomas Gardner
  • COMPOSITIONS AND METHODS OF GENOMIC MODIFICATION OF CELLS AND USES THEREOF
    Publication number: 20230365997
    Abstract: Provided herein are compositions and methods for producing genomically edited cells expressing an exogenous transgene and restored or continued expression of an endogenous gene. Methods of using the genomically edited cells for treating or preventing a disease in a subject are also provided.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 16, 2023
    Inventors: Aaron Cooper, Angela Boroughs, Pei-Ken Hsu
  • CAR T CELL TRANSCRIPTIONAL ATLAS
    Publication number: 20220170097
    Abstract: The invention relates to gene expression profiles and signatures of CAR T cells. The invention provides methods and compositions of CAR T cells and populations. The invention provides assays and methods of screening subjects to assess efficacy and safety of CAR T cell treatments and therapies. The invention provides assays and methods of engineering and/or administering CAR T cells to promote efficacy and safety.
    Type: Application
    Filed: October 29, 2019
    Publication date: June 2, 2022
    Inventors: Angela Boroughs, Nemo Marjanovic, Aviv Regev, Marcela Maus, Tamara Ouspenskaia
  • METHODS AND COMPOSITIONS RELATING TO ENGINEERED REGULATORY T CELLS
    Publication number: 20200330515
    Abstract: The invention provides herein engineered regulatory T cells (Tregs), compositions thereof, and their methods of use. The Tregs described herein can be engineered to include, e.g., a chimeric antigen receptor (CAR), conferring increased stability, specificity, and immunosuppressive activity towards a target antigen. Furthermore, Tregs can also be engineered to reduce T cell cytotoxicity functions. Also provided are methods of suppressing immune response against a specific target antigen using the engineered Tregs described herein.
    Type: Application
    Filed: October 3, 2018
    Publication date: October 22, 2020
    Inventors: Marcela V. MAUS, Angela BOROUGHS