Patents by Inventor Angela Doneanu

Angela Doneanu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced sensitivity of detection in electrospray ionization mass spectrometry using a post-column modifier and a microfluidic device
    Patent number: 9528968
    Abstract: A microfluidic liquid chromatography-electrospray ionization (LC-ESI) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent. The mixed flow stream thus obtained is used for generating an electrospray containing analyte ions. Also provided are methods for enhanced sensitivity of detection of an analyte in a sample.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: December 27, 2016
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: James P. Murphy, Angela Doneanu
  • ENHANCED SENSITIVITY OF DETECTION IN ELECTROSPRAY IONIZATION MASS SPECTROMETRY USING A POST-COLUMN MODIFIER AND A MICROFLUIDIC DEVICE
    Publication number: 20160131620
    Abstract: A microfluidic liquid chromatography-electrospray ionization (LC-ESI) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent. The mixed flow stream thus obtained is used for generating an electrospray containing analyte ions. Also provided are methods for enhanced sensitivity of detection of an analyte in a sample.
    Type: Application
    Filed: October 13, 2015
    Publication date: May 12, 2016
    Applicant: Waters Technologies Corporation
    Inventors: James P. Murphy, Angela Doneanu
  • Temperature Control Of Enrichment And Separation Columns In Chromatography
    Publication number: 20120171773
    Abstract: A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.
    Type: Application
    Filed: May 27, 2010
    Publication date: July 5, 2012
    Applicant: Waters Technologies Corporation
    Inventors: James P. Murphy, Keith Fadgen, Geoff C. Gerhardt, Angela Doneanu, Martha Degen Stapels