Patents by Inventor Angela HÜCKELHOVEN

Angela HÜCKELHOVEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Influenza-specific T-cell receptor and its uses in the detection, prevention and/or treatment of influenza
    Patent number: 10370427
    Abstract: The present invention relates to specific T-cell receptor a-chains, T-cell receptor ?-chains and T-cell receptors comprising said T-cell receptor a-chain and/or ?-chain. In particular, the invention relates to T-cell receptors and/or chains binding to the influenza matrix peptide GILGFVFTL (GL9 peptide) presented by Human Leukocyte antigen A2 (HLA-A2) molecules. The present invention further relates to soluble TCR constructs, chimeric TCRs, nucleic acids, expression constructs and cells comprising said TCR a-chain and/or ?-chain or the respective TCR. The present invention further relates to the use of the TCR a-chain and/or ?-chain or the respective TCR or the soluble TCR constructs or chimeric TCRs as a medicament, preferably in the detection, prevention and/or treatment of influenza. The present invention further relates to methods of detecting, preventing and/or treating influenza.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: August 6, 2019
    Assignee: Friedrich-Alexander Universität Erlangen-Nürnberg
    Inventors: Thomas Harrer, Angela Hückelhoven
  • Influenza-Specific T-Cell Receptor and its Uses in the Detection, Prevention and/or Treatment of Influenza
    Publication number: 20160297864
    Abstract: The present invention relates to specific T-cell receptor a-chains, T-cell receptor ?-chains and T-cell receptors comprising said T-cell receptor a-chain and/or ?-chain. In particular, the invention relates to T-cell receptors and/or chains binding to the influenza matrix peptide GILGFVFTL (GL9 peptide) presented by Human Leukocyte antigen A2 (HLA-A2) molecules. The present invention further relates to soluble TCR constructs, chimeric TCRs, nucleic acids, expression constructs and cells comprising said TCR a-chain and/or ?-chain or the respective TCR. The present invention further relates to the use of the TCR a-chain and/or ?-chain or the respective TCR or the soluble TCR constructs or chimeric TCRs as a medicament, preferably in the detection, prevention and/or treatment of influenza. The present invention further relates to methods of detecting, preventing and/or treating influenza.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 13, 2016
    Inventors: Thomas HARRER, Angela HÜCKELHOVEN