Patents by Inventor Angela K. Cruz

Angela K. Cruz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Double targeted gene replacement in unicellular diploid organisms
    Patent number: 6228649
    Abstract: Homozygous gene replacement can be created in unicellular diploid organisms by individually targeting each allele of a gene with genetic constructs containing two different and independent selectable markers. Selection for both markers indicates replacement of both alleles of the gene, or portion thereof. The method can be used to study gene function in these organisms and to create mutant organisms such as attenuated strains of parasitic protozoans for use in live vaccines.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: May 8, 2001
    Assignee: President and Fellows of Harvard College
    Inventors: Stephen M. Beverley, Angela K. Cruz
  • Double targeted gene replacement in unicellular diploid organisms
    Patent number: 5955333
    Abstract: Homozygous gene replacement can be created in unicellular diploid organisms by individually targeting each allele of a gene with genetic constructs containing two different and independent selectable markers. Selection for both markers indicates replacement of both alleles of the gene, or portion thereof. The method can be used to study gene function in these organisms and to create mutant organisms such as attenuated strains of parasitic protozoans for use in live vaccines.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: September 21, 1999
    Assignee: President & Fellows of Harvard College
    Inventors: Stephen M. Beverley, Angela K. Cruz