Patents by Inventor Angela M. BARDO

Angela M. BARDO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR POLYPEPTIDE PROCESSING AND ANALYSIS
    Publication number: 20240125805
    Abstract: Provided herein are methods for analyzing polypeptides and polypeptide complexes. Methods of the present disclosure may be used to identify protein subunits present in a polypeptide, polypeptide complex, or aggregate. These methods may also be used to quantify the subunits (e.g. number of repeating units, protein monomers, repeating domains) in a polypeptide, polypeptide complex, or aggregate.
    Type: Application
    Filed: February 24, 2022
    Publication date: April 18, 2024
    Inventors: Edward MARCOTTE, Eric ANSLYN, Jagannath SWAMINATHAN, Angela M. BARDO
  • METHODS, SYSTEMS AND KITS FOR POLYPEPTIDE PROCESSING AND ANALYSIS
    Publication number: 20240002925
    Abstract: Provided herein are compositions, systems, methods, and kits for peptide analysis, including peptide sequencing. Aspects of the present disclosure provide bifunctional reagents which may selectively couple to amino acids and selectively couple to detectable species. Aspects of the present disclosure further provide methods for using these bifunctional reagents to sequence and analyze peptides.
    Type: Application
    Filed: November 18, 2022
    Publication date: January 4, 2024
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Eric V. ANSLYN, Edward MARCOTTE, Cecil J. HOWARD, II, Jagannath SWAMINATHAN, Angela M. BARDO, Brendan FLOYD, Brandon HOSFORD, Le ZHANG, Emily Faith BABCOCK, Caroline M. HINSON
  • SINGLE MOLECULE SEQUENCING PEPTIDES BOUND TO THE MAJOR HISTOCOMPATIBILITY COMPLEX
    Publication number: 20230103041
    Abstract: The present disclosure provides methods of identifying and quantifying the peptides displayed by the major histocompatibility complex (MHC). Such methods may comprise the ability to determine the type, identity, and quantity of each peptide displayed by the MHC. In some embodiments, these methods may be used to develop an anti-cancer therapy or type the HLA of a patient. Also provided herein are compositions comprising peptides from the MHC which have been prepared for sequencing.
    Type: Application
    Filed: October 27, 2022
    Publication date: March 30, 2023
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Edward MARCOTTE, Eric ANSLYN, Alexander BOULGAKOV, Angela M. BARDO, Siyuan Stella WANG, Jagannath SWAMINATHAN, Fan TU
  • PEPTIDE AND PROTEIN C-TERMINUS LABELING
    Publication number: 20230076975
    Abstract: Described herein are methods for selectively cleaving the C-terminal amino acid of a peptide or protein. The methods described herein may be applicable for, for example, single-molecule peptide or protein sequencing.
    Type: Application
    Filed: August 18, 2022
    Publication date: March 9, 2023
    Inventors: Eric V. ANSLYN, Edward MARCOTTE, Cecil J. HOWARD, II, Jagannath SWAMINATHAN, Angela M. BARDO, Caroline M. HINSON, Brendan FLOYD, Le ZHANG
  • SOLID-PHASE N-TERMINAL PEPTIDE CAPTURE AND RELEASE
    Publication number: 20210356473
    Abstract: Provided herein are rapid and reversible methods to non-specifically immobilize peptides and proteins irrespective of their sequence, as well as small molecules, on a solid support to allow for manipulations of and reactions with these molecules in a manner that does not require purification between steps, which increases sample yield and reduces the quantity of starting material required.
    Type: Application
    Filed: October 4, 2019
    Publication date: November 18, 2021
    Inventors: Eric ANSLYN, Edward MARCOTTE, Cecil J. HOWARD, II, Jagannath SWAMINATHAN, Angela M. BARDO, Brendan M. FLOYD, James REUTHER
  • SINGLE MOLECULE SEQUENCING PEPTIDES BOUND TO THE MAJOR HISTOCOMPATIBILITY COMPLEX
    Publication number: 20210215707
    Abstract: The present disclosure provides methods of identifying and quantifying the peptides displayed by the major histocompatibility complex (MHC). Such methods may comprise the ability to determine the type, identity, and quantity of each peptide displayed by the MHC. In some embodiments, these methods may be used to develop an anti-cancer therapy or type the HLA of a patient. Also provided herein are compositions comprising peptides from the MHC which have been prepared for sequencing.
    Type: Application
    Filed: August 14, 2019
    Publication date: July 15, 2021
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Edward MARCOTTE, Eric ANSLYN, Alexander BOULGAKOV, Angela M. BARDO, Siyuan Stella WANG, Jagannath SWAMINATHAN, Fan TU
  • SINGLE MOLECULE SEQUENCING IDENTIFICATION OF POST-TRANSLATIONAL MODIFICATIONS ON PROTEINS
    Publication number: 20210215706
    Abstract: The present disclosure provides methods of selectively label an amino acid residue on a peptide by replacing a post translational modification with a labeling moiety and sequencing the peptide to obtain the location of the amino acid residue and the identity of the post translational modification. In some aspects, the disclosure also provides methods of identifying the position, quantity, the identity of a post translational modification, or any combination thereof, in peptides which may be used for therapeutic purposes.
    Type: Application
    Filed: January 22, 2021
    Publication date: July 15, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Edward MARCOTTE, Eric ANSLYN, Jagannath SWAMINATHAN, Angela M. BARDO, Caroline M. HINSON, Cecil HOWARD, Brendan FLOYD