Patents by Inventor Angela Mohs

Angela Mohs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPIDS AS SYNTHETIC VECTORS TO ENHANCE ANTIGEN PROCESSING AND PRESENTATION EX-VIVO IN DENDRITIC CELL THERAPY
    Publication number: 20180353599
    Abstract: The invention covers the use of certain classes of lipids including cationic lipids in ex-vivo dendritic cell therapies. The cationic lipids enhance antigen uptake, processing and presentation of the processed antigens by dendritic cells to CD8+ and CD4+ T-cells via the MHC classes I and II presentation pathways respectively. Antigen uptake via cationic lipid by dendritic cells result in significant lowering of the population of the immune suppressive regulatory T cells in the tumors and a significant increase of the tumor targeting cytotoxic T-cells. Loss of regulatory T cells and increase of tumor specific cytotoxic cells are conducive to effective elimination of the tumors.
    Type: Application
    Filed: November 14, 2016
    Publication date: December 13, 2018
    Inventors: Frank Bedu-Addo, Greg Conn, Siva K. Gandhapudi, Martin Keough, Angela Mohs, Ritu Patel, Shweta Singh, Martin Ward, Jerold Woodward
  • STABLE FORMULATIONS OF ANTIBODIES TO TSLP
    Publication number: 20140227250
    Abstract: The present invention relates to stable formulations of antibodies against human TSLP, or antigen binding fragments thereof.
    Type: Application
    Filed: August 21, 2013
    Publication date: August 14, 2014
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Yunsong Li, Valentyn Antochshuk, Anita Dabbara, Angela Mohs, Alexandre Ambrogelly