Abstract: Methods and systems for treating a biological fluid with light are disclosed. The methods and systems provide for determining a target light dose for the biological fluid; loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: with the treatment container being supported in the irradiation device in between a first array of light sources and first light energy sensors and a second light energy sensor. The first array of light sources is activated, and a first light intensity is measured with the first light energy sensors. A second light intensity is measured with the second light energy sensor, and the first light intensity is compared to the second light intensity to determine an attenuation factor. The attenuation factor is applied to the first light intensity to determine a time to achieve the target light dose, with the first array of multiple light sources being deactivated after the time to achieve the target light dose has elapsed.

Abstract: Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection.

Abstract: Systems and methods for performing apheresis procedures, including photopheresis, are disclosed. The systems and methods utilize a disposable fluid circuit that can be converted from a double needle configuration to a single needle configuration and from a single needle configuration to a double needle configuration. A controller directs the action of system pumps to clear potentially stagnant blood residing in the fluid circuit, tracks system parameters and status before and after conversion, and verifies that the procedure may proceed in its new configuration.

Abstract: Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. During a mononuclear cell collection cycle, blood is removed from a source and separated into a plasma constituent, a mononuclear cell-containing layer, and red blood cells, followed by the collection of a pre-product including at least a portion of the mononuclear cell-containing layer and at least a portion of the separated red blood cells. The mononuclear cell collection cycle may be repeated, followed by the production of a single mononuclear cell product using the collected pre-product(s). The mononuclear cell product is irradiated using a fixed dose of light, such that the mononuclear cell product is produced so as to have a predetermined volume and a predetermined hematocrit, regardless of the number of pre-products used to produce the mononuclear cell product. Following irradiation, at least a portion of the irradiated mononuclear cell product is returned to the source.

Abstract: Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection.

Abstract: Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection.

Abstract: Methods and systems for treating a biological fluid with light are disclosed. The methods and systems provide for determining a target light dose for the biological fluid; loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: with the treatment container being supported in the irradiation device in between a first array of light sources and first light energy sensors and a second light energy sensor. The first array of light sources is activated, and a first light intensity is measured with the first light energy sensors. A second light intensity is measured with the second light energy sensor, and the first light intensity is compared to the second light intensity to determine an attenuation factor. The attenuation factor is applied to the first light intensity to determine a time to achieve the target light dose, with the first array of multiple light sources being deactivated after the time to achieve the target light dose has elapsed.

Abstract: Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. During a mononuclear cell collection cycle, blood is removed from a source and separated into a plasma constituent, a mononuclear cell-containing layer, and red blood cells, followed by the collection of a pre-product including at least a portion of the mononuclear cell-containing layer and at least a portion of the separated red blood cells. The mononuclear cell collection cycle may be repeated, followed by the production of a single mononuclear cell product using the collected pre-product(s). The mononuclear cell product is irradiated using a fixed dose of light, such that the mononuclear cell product is produced so as to have a predetermined volume and a predetermined hematocrit, regardless of the number of pre-products used to produce the mononuclear cell product. Following irradiation, at least a portion of the irradiated mononuclear cell product is returned to the source.

Abstract: Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection.