Patents by Inventor Angela Nicole KOEHLER

Angela Nicole KOEHLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule binders of the oncogenic fusion transcription factor PAX3-FOXO1
    Patent number: 11964022
    Abstract: The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: April 23, 2024
    Assignees: Massachusetts Institute of Technology, Universität Zürich
    Inventors: Angela Nicole Koehler, Shelby Doyle, Becky Leifer, Madeleine Henley, Beat W. Schaefer, Marco Wachtel
  • Small Molecule Binders of the Oncogenic Fusion Transcription Factor PAX3-FOXO1
    Publication number: 20230149552
    Abstract: The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.
    Type: Application
    Filed: September 16, 2022
    Publication date: May 18, 2023
    Inventors: Angela Nicole Koehler, Shelby Doyle, Becky Leifer, Matthew Henley, Beat W. Schaefer, Marco Wachtel
  • SMALL MOLECULE INHIBITORS OF INTERLEUKIN-4
    Publication number: 20210317114
    Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.
    Type: Application
    Filed: March 19, 2021
    Publication date: October 14, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Arturo VEGAS, Sean QUINNELL, Daniel SHEEHY, Kelly TAN, Luke CEO, Stephen Thomas NESTOR, Angela Nicole KOEHLER, Becky LEIFER, Shelby DOYLE